Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Carolyn L. Doerr"'
Publikováno v:
Molecular and Cellular Biochemistry. 279:113-121
We investigated the spindle inhibitory properties of six arsenicals differing in their methylation or oxidation state. Human lymphoblasts were exposed for 6 h to either sodium arsenate (NaAs(V)), sodium arsenite (NaAs(III)), monomethylarsonic acid (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd51e12e8e452623705972739c4eebc
https://doi.org/10.1007/s11010-005-8283-3
https://doi.org/10.1007/s11010-005-8283-3
Autor:
Marc J. Mass, Bijit Kundu, Andrew D. Kligerman, David M. DeMarini, Carolyn L. Doerr, James W. Allen, Karen Harrington-Brock, Barbara C. Roop, Ernest Winkfield, Alan H. Tennant, P. Poorman-Allen, Kunihiro Funasaka
Publikováno v:
Environmental and Molecular Mutagenesis. 42:192-205
Arsenic is a prevalent human carcinogen whose mutagenicity has not been characterized fully. Exposure to either form of inorganic arsenic, As(III) or As(V), can result in the formation of at least four organic metabolites: monomethylarsonic acid, mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c49a2afe73cd9a1462078ffaf7c2b0
https://doi.org/10.1002/em.10192
https://doi.org/10.1002/em.10192
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 471:107-112
Atrazine, simazine, and cyanazine are widely used preemergence and postemergence triazine herbicides that have made their way into the potable water supply of many agricultural communities. Although there are several contradictory genotoxicity studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73c12c79476b71004258db1fa2bdd65
https://doi.org/10.1016/s1383-5718(00)00124-8
https://doi.org/10.1016/s1383-5718(00)00124-8
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 413:265-276
The disinfection of water, required to make it safe for human consumption, leads to the presence of halogenated organic compounds. Three of these carcinogenic `disinfection by-products', dichloroacetic acid (DCA), trichloroacetic acid (TCA) and chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852c2dc414b92a3a10944893c23cee9d
https://doi.org/10.1016/s1383-5718(98)00026-6
https://doi.org/10.1016/s1383-5718(98)00026-6
Publikováno v:
Mutation Research/Reviews in Mutation Research. 386:279-290
Arsenic is one of the few identified human carcinogens that has yet to be shown to cause cancer in rodents when the standard bioassay protocols are used. The reasons for this apparent interspecies difference are unclear but may be related to differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134d1b13fedf1ac762edd3dca2e9c38a
https://doi.org/10.1016/s1383-5742(97)00003-3
https://doi.org/10.1016/s1383-5742(97)00003-3
Autor:
J. K. McGee, Gregory L. Erexson, Carolyn L. Doerr, Puntipa Kwanyuen, Miriam F. Bryant, Andrew D. Kligerman
Publikováno v:
Environmental and Molecular Mutagenesis. 23:186-189
Phosphine (PH3) is a highly toxic grain fumigant that can be produced from the reaction of metal phosphides with water. To determine the in vivo cytogenetic effects of inhalation of PH3, male CD-1 mice were exposed to either 0, 5, 10, or 15 ppm targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa61e3dcc93e9b6b0f2a16ecf0b5b66
https://doi.org/10.1002/em.2850230306
https://doi.org/10.1002/em.2850230306
Autor:
Carolyn L. Doerr, Martha M. Moore
Publikováno v:
Mutagenesis. 5:609-614
The L5178Y/TK(+/-)-3.7.2C mouse lymphoma assay is used to quantitate the induction of thymidine kinase (TK)-deficient mutants. The mutants detected in the assay form colonies that can be distinguished as large or small. The induction of small-colony
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644c302d3bc23c0829e49968c3eae7bf
https://doi.org/10.1093/mutage/5.6.609
https://doi.org/10.1093/mutage/5.6.609
Autor:
Rob McConnell, Marta Cabrera, Martha M. Moore, Karen Harrington-Brock, James C Fuscoe, Hernan Sandoval, Carolyn L Doerr, Deborah D. Collard
Publikováno v:
Mutation research. 431(2)
A pilot biomarker study was conducted to investigate the feasibility of using the hypoxanthine guanine phosphoribosyltransferase (HPRT) gene in peripheral blood lymphocytes as a biomarker for detecting genetic effects of arsenic exposure. Blood and u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380d1e340b5d9e8d45c10953ae9a1da5
https://pubmed.ncbi.nlm.nih.gov/10635991
https://pubmed.ncbi.nlm.nih.gov/10635991
Publikováno v:
Mutation research. 444(1)
3,4-Epoxy-1-butene (EB), a primary metabolite of butadiene, is a direct-acting “S-dependent” genotoxicant that can induce sister chromatid exchanges (SCEs) and chromosome aberrations (CAs) in cycling cells in vitro. However, EB is almost inactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49894f331cf5ec79664505fb9510c1ce
https://pubmed.ncbi.nlm.nih.gov/10477349
https://pubmed.ncbi.nlm.nih.gov/10477349
Autor:
Alan H. Tennant, Carolyn L Doerr, Andrew D. Kligerman, Velva S. Milholland, David M. DeMarini, Nancy M. Hanley
Publikováno v:
Mutation research. 439(1)
To understand better the species differences in carcinogenicity caused by 1,3-butadiene (BD), we exposed G0 lymphocytes (either splenic or peripheral blood) from rats, mice and humans to 3, 4-epoxy-1-butene (EB) (20 to 931 microM) or 1,2:3,4-diepoxyb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064fcf16269312b54cfbdbfb4b922e93
https://pubmed.ncbi.nlm.nih.gov/10029668
https://pubmed.ncbi.nlm.nih.gov/10029668