Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Carolyn L. Cummins"'
Autor:
Cigdem Sahin, Jenna-Rose Melanson, Florian Le Billan, Lilia Magomedova, Thais A.M. Ferreira, Andressa S. Oliveira, Evan Pollock-Tahari, Michael F. Saikali, Sarah B. Cash, Minna Woo, Luiz A.S. Romeiro, Carolyn L. Cummins
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101958- (2024)
Objective: The prevalence of metabolic diseases is increasing globally at an alarming rate; thus, it is essential that effective, accessible, low-cost therapeutics are developed. Peroxisome proliferator-activated receptors (PPARs) are transcription f
Externí odkaz:
https://doaj.org/article/cfebdf9a904b44948be866fb0310321e
Autor:
Marel Gonzalez Medina, Zhiwei Liu, Johny Wang, Cindy Zhang, Sarah B. Cash, Carolyn L. Cummins, Adria Giacca
Publikováno v:
Cells, Vol 13, Iss 16, p 1387 (2024)
Restenosis following percutaneous revascularization is a major challenge in patients with insulin resistance and diabetes. Currently, the vascular effects of insulin are not fully understood. In vitro, insulin’s effects on endothelial cells (ECs) a
Externí odkaz:
https://doaj.org/article/9bfe782017e04cfb9d4180f37729bb49
Autor:
Waqar Arif, Bhoomika Mathur, Michael F. Saikali, Ullas V. Chembazhi, Katelyn Toohill, You Jin Song, Qinyu Hao, Saman Karimi, Steven M. Blue, Brian A. Yee, Eric L. Van Nostrand, Sushant Bangru, Grace Guzman, Gene W. Yeo, Kannanganattu V. Prasanth, Sayeepriyadarshini Anakk, Carolyn L. Cummins, Auinash Kalsotra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Nonalcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease with complex pathogenic mechanisms. Here, the authors report that SRSF1 deficiency in mice livers provokes deleterious R-loop formation and genotoxicity, which impedes hep
Externí odkaz:
https://doaj.org/article/ee830a8f79654480908b12970aefaf07
Autor:
Idit Dotan, Jiaqi Yang, Jiro Ikeda, Ziv Roth, Evan Pollock-Tahiri, Harsh Desai, Tharini Sivasubramaniyam, Sonia Rehal, Josh Rapps, Yu Zhe Li, Helen Le, Gedaliah Farber, Edouard Alchami, Changting Xiao, Saraf Karim, Marcela Gronda, Michael F. Saikali, Amit Tirosh, Kay-Uwe Wagner, Jacques Genest, Aaron D. Schimmer, Vikas Gupta, Mark D. Minden, Carolyn L. Cummins, Gary F. Lewis, Clinton Robbins, Jenny Jongstra-Bilen, Myron Cybulsky, Minna Woo
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Loss of myeloid JAK2 promotes atherosclerosis in an ApoE knockout mouse model. This is associated with decreased cholesterol efflux from bone-marrow-derived macrophages.
Externí odkaz:
https://doaj.org/article/8f5bbf65f53546318be8781e62cd0a46
Autor:
Adil Rasheed, Sarah A. Shawky, Ricky Tsai, Richard G. Jung, Trevor Simard, Michael F. Saikali, Benjamin Hibbert, Katey J. Rayner, Carolyn L. Cummins
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 479-491 (2021)
Abstract Endothelial progenitor cells (EPCs) promote the maintenance of the endothelium by secreting vasoreparative factors. A population of EPCs known as early outgrowth cells (EOCs) is being investigated as novel cell‐based therapies for the trea
Externí odkaz:
https://doaj.org/article/3046695fb43846b1836880d2cf1f986b
Autor:
Lin Lin, Adam H. Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1480-1490 (2020)
N-acylethanolamines (NAEs) are endogenous lipid-signaling molecules derived from fatty acids that regulate numerous biological functions, including in the brain. Interestingly, NAEs are elevated in the absence of fatty acid amide hydrolase (FAAH) and
Externí odkaz:
https://doaj.org/article/8cbeb7ea77204ce5bc9594c99657bab0
Autor:
Muntasir Kamal, Houtan Moshiri, Lilia Magomedova, Duhyun Han, Ken C. Q. Nguyen, May Yeo, Jessica Knox, Rachel Bagg, Amy M. Won, Karolina Szlapa, Christopher M. Yip, Carolyn L. Cummins, David H. Hall, Peter J. Roy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The C. elegans nematode worm is a filter-feeder and requires dietary sources of cholesterol. Here, the authors show that the C. elegans pharynx works as a filter to scavenge hydrophobic small molecules from its surrounding liquid environment.
Externí odkaz:
https://doaj.org/article/01ca567f548348c9ac82fe0b636300c0
Autor:
Jens Tiefenbach, Lilia Magomedova, Jiabao Liu, Arkadiy A. Reunov, Ricky Tsai, Neena S. Eappen, Rebecca A. Jockusch, Corey Nislow, Carolyn L. Cummins, Henry M. Krause
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Current peroxisome proliferator-activated receptor (PPAR)-targeted drugs, such as the PPARγ-directed diabetes drug rosiglitazone, are associated with undesirable side effects due to robust agonist activity in non-target tissues. To find new PPAR lig
Externí odkaz:
https://doaj.org/article/725afbfba88d4a8cb07d45d378db7066
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
BackgroundThe liver X receptors (LXRs; α/β) are nuclear receptors known to regulate cholesterol homeostasis and the production of select hematopoietic populations. The objective of this study was to determine the importance of LXRs and a high‐fat
Externí odkaz:
https://doaj.org/article/8316856eb2ed47fa9975cc039d389cee
Autor:
Adil Rasheed, Carolyn L. Cummins
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2307 (2018)
Atherosclerosis is a chronic condition associated with cardiovascular disease. While largely identified by the accumulation of lipid-laden foam cells within the aorta later on in life, atherosclerosis develops over several stages and decades. During
Externí odkaz:
https://doaj.org/article/6228f10002f44aa3b6bece1cd2147f29