Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Carolyn Kravitz"'
Autor:
Sally J. Adua, Anna Arnal-Estapé, Minghui Zhao, Bowen Qi, Zongzhi Z. Liu, Carolyn Kravitz, Heather Hulme, Nicole Strittmatter, Francesc López-Giráldez, Sampada Chande, Alexandra E. Albert, Mary-Ann Melnick, Bomiao Hu, Katerina Politi, Veronica Chiang, Nicola Colclough, Richard J. A. Goodwin, Darren Cross, Paul Smith, Don X. Nguyen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
While EGFR-targeted therapies have clinical benefit, drug-resistant brain metastases present a major obstacle. Here, the authors identify a genetic signature in brain metastatic lesions associated with osimertinib resistance and find RhoA to have an
Externí odkaz:
https://doaj.org/article/3190ed6c2b6648c6bd0e559653995e8f
Autor:
Sally J. Adua, Anna Arnal-Estapé, Minghui Zhao, Bowen Qi, Zongzhi Z. Liu, Carolyn Kravitz, Heather Hulme, Nicole Strittmatter, Francesc López-Giráldez, Sampada Chande, Alexandra E. Albert, Mary-Ann Melnick, Bomiao Hu, Katerina Politi, Veronica Chiang, Nicola Colclough, Richard J. A. Goodwin, Darren Cross, Paul Smith, Don X. Nguyen
Publikováno v:
Nature communications. 13(1)
The brain is a major sanctuary site for metastatic cancer cells that evade systemic therapies. Through pre-clinical pharmacological, biological, and molecular studies, we characterize the functional link between drug resistance and central nervous sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04e78cb624cba2a6d0725e25ddbc92b
https://pubmed.ncbi.nlm.nih.gov/36509758
https://pubmed.ncbi.nlm.nih.gov/36509758