Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington’s Disease Patients—A Randomized Phase 2 Clinical Trial

Autor: Melanie Benge, Amie L. Hiller, Carolyn Gray, Michele Costigan, H. Diana Rosas, Stephanie Lowenhaupt, Rosalind S Chuang, Peter Hedera, Danny Bega, Matthew J. Barrett, Marianne Chase, Jon W. Yankey, Jessica Lamb, Elaine Sperin, Susan Perlman, Christina Gruenwald, Joseph F. Quinn, Joyce Ann Moran, Lauren Seeberger, Debra E Itzkowitz, Brenton A Wright, Kelly Lowen, Karen E. Anderson, Victor W. Sung, Angela Molloy, Frederick J. Marshall, Patricia Conlon, Hilda T Maibach, Jamie L Adams, Elaine Most, Stewart A. Factor, Karen Marder, Allison M. Daley, Shifang Lu, Carlos Singer, Michael J Brownstein, Neal G. Simon, Amy M Chesire, Valerie Suski, Codrin Lungu, Kellie Keith, Christopher S. Coffey, Guy J Schwartz, Zsazsa R Brown, Richard Dubinsky, Catherine Gladden, Paola Wall, Jeremy M. Shefner, Steven M. Hersch, Cara Jacob, Jeffrey D. Long, Dixie Ecklund, Padraig E. O'Suilleabhain, Andrew P. Duker, J. Singleton, Meghan Zorn, Carolyn Drazinic, Mark Quigg, Eve M Damiano, Sandra K. Kostyk, Brenda Thornell, Andrew McGarry, Merit Cudkowicz, Robin Conwit, Paul Deritis, Joel S. Perlmutter

Publikováno v: Journal of Clinical Medicine
Volume 9
Issue 11
Journal of Clinical Medicine, Vol 9, Iss 3682, p 3682 (2020)

SRX246 is a vasopressin (AVP) 1a receptor antagonist that crosses the blood-brain barrier. It reduced impulsive aggression, fear, depression and anxiety in animal models, blocked the actions of intranasal AVP on aggression/fear circuits in an experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6ab53df7b21fa094318e696048bfcc

The Miser of Middlegate

Autor: Carolyn Gray

Set in modern day Winnipeg, Gray's inspired version of Moliere's classic satire is part sex farce and part screwball comedy. Exploring family, love and money, The Miser of Middlegate sharply critiques our culture obsessed with acquisition and never l

Dean Gunnarson : The Making of an Escape Artist

Autor: Carolyn Gray

Dean Gunnarson, world-renowned escapologist, has made a career of avoiding death. But his first escape was his greatest -- surviving juvenile leukemia. In the wake of his illness, a magic-obsessed young Dean mirrors the training of his hero Houdini i

Comparing Daily Class Schedule and its Influence on Undergraduate Students’ Physical Activity Patterns

Autor: Dina D. Kendle, M. Moran, Carolyn Gray, Marissa Ruggiero, Praveen Veerabhadrappa, Kristen Gift, Matthew B. Rhudy

Publikováno v: Medicine & Science in Sports & Exercise. 49:618-619

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b5298ce9c0ff97fbb511fa26a9ec303
https://doi.org/10.1249/01.mss.0000518623.15717.dc

Predictors of diagnosis in Huntington disease

Autor: Ira Shoulson, Donald S. Higgins, Mark Guttman, Marie Saint-Hilaire, Gina Rohs, Rose Schwarz, M. Sherr, Jackie Thomson, Vicki L. Wheelock, Charlyne Hickey, Kathleen M. Shannon, Kathleen Francis, Eric Siemers, Andrew Feigin, Elan D. Louis, Phillipa Hedges, Jang Ho John Cha, Greg Rudolf, Stuart Taylor, Joseph H. Friedman, Francis O. Walker, Cindy Lied, Frederick J. Marshall, Joseph Jankovic, J. Timothy Greenamyre, Peter Como, Alexander P. Auchus, Karen Caplan, Carmen Polanco, Kathy Claude, Irenita Gardiner, Lynn A. Raymond, M. Nance, Ronald Trent, Michael R. Hayden, Robert L. Rodnitzky, Nanette Mercado, Neal R. Swerdlow, Jennifer Mazurkiewicz, Adam Rosenblatt, Vicki Hunt, Charles H. Adler, Kristine Wernette, Joanne Wojcieszek, Richard Dubinsky, Carol Zimmerman, Stephanie Newman, Diane Brown, Henry L. Paulson, Samantha Pearce, Carol A. Manning, Janet S. Cellar, Elise Kayson, Michael R. Swenson, Michael P. McDermott, Margaret C. Lannon, Ruth Cummings, Walter J. Koroshetz, Roger L. Albin, Kenneth Marek, Sandra Russell, Tetsuo Ashizawa, Douglas R. Langbehn, Ann Catherine Bachoud-Levi, Ted M. Dawson, Paula Sexton, Jonelle Adams, Susan Cleary, Carolyn Gray, Dwight J. Stewart, John N. Caviness, Jane B. Lane, Elizabeth McCusker, Leon S. Dure, Juan Sanchez-Ramos, David A. Abwender, Naomi Zubin, W.R. Wayne Martin, Karen Marder, Audrey Walker, Nancy Pearson, Allen Rubin, Kerry Duncan, Jackie Gray, Randi Jones, Lynn Vining, Robert A. Hauser, Carol Moskowitz, Carson Reider, Stewart A. Factor, Elke Rost-Ruffner, Lauren Seeberger, Hartmut Meierkord, Alicia Facca, J. Beach, Oksana Suchowersky, Elizabeth Leritz, Marguerite Wieler, Catherine Brown, Merit Cudkowicz, Jane S. Paulsen, Cindy Hunter, Kim Lane, Karl Kieburtz, Joan Lawrence, Eric Molho, Alicia Brocht, Steven M. Hersch, Jill Burke-Holder, Madeline Harrison, Joshua L. Goldstein, Anders Lundin, Gustavo Rey, Anne B. Young, Jeana Jaglin, David Olson, Daniel S. Sax, William J. Weiner, Candace Young, David Oakes, Jody Corey-Bloom

Publikováno v: Neurology. 68:1710-1717

Objective: Subtle signs and symptoms of Huntington disease (HD) are often present before impairments reach a point where the neurologic disease is manifest and a diagnosis must be considered. The objective is to examine the prognostic significance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2311733c60e2998c7d15286264f016ad
https://doi.org/10.1212/01.wnl.0000261918.90053.96