Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Carolyn G King"'
Publikováno v:
eLife, Vol 10 (2021)
A hallmark of adaptive immunity is CD4 T cells’ ability to differentiate into specialized effectors. A long-standing question is whether T cell receptor (TCR) signal strength can dominantly instruct the development of Th1 and T follicular helper (T
Externí odkaz:
https://doaj.org/article/fab26f24ed194989915652fbcd6a54bf
Autor:
Veronika Horkova, Ales Drobek, Daniel Mueller, Celine Gubser, Veronika Niederlova, Lena Wyss, Carolyn G. King, Dietmar Zehn, Ondrej Stepanek
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1504-1514.e7 (2020)
Summary: Overtly self-reactive T cells are removed during thymic selection. However, it has been recently established that T cell self-reactivity promotes protective immune responses. Apparently, the level of self-reactivity of mature T cells must be
Externí odkaz:
https://doaj.org/article/4442a1007c8244559d23d9147e2200f3
Autor:
David Schreiner, Carolyn G. King
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
During the last 10 years, a population of clonally expanded T cells that take up permanent residence in non-lymphoid tissues has been identified. The localization of these tissue resident memory (TRM) cells allows them to rapidly respond at the site
Externí odkaz:
https://doaj.org/article/98b09a18051e4729bbfcc5a2d5f825d2
Publikováno v:
Current Opinion in Immunology. 81:102284
Autor:
Doron Merkler, Ingrid Wagner, Mario Kreutzfeldt, Karen Cornille, Tobias M. Brunner, Marco Künzli, David Schreiner, Kerstin Narr, Mirela Dimitrova, Yusuf I. Ertuna, Lukas Bestmann, Benedict Fallet, Max Löhning, Carolyn G. King, Tiago Jose Abreu Mota, Anna-Friederike Marx, Florian Geier, Katrin Martin, Daniel D. Pinschewer
Publikováno v:
Proc Natl Acad Sci U S A
Chronic viral infections subvert protective B cell immunity. An early type I interferon (IFN-I)-driven bias to short-lived plasmablast differentiation leads to clonal deletion, so-called "decimation," of antiviral memory B cells. Therefore, prophylac
Autor:
Marco Künzli, Carolyn G. King
Publikováno v:
Trends in Immunology. 41:454-456
T resident memory (Trm) cells provide a first line of defense in non-lymphoid tissues. A new report in Nature Immunology by Fonseca et al. reveals that CD8+ Trm cells can give rise to circulating effector and memory T cells, but remain predisposed to
Autor:
Jonas, Lötscher, Adrià-Arnau, Martí I Líndez, Nicole, Kirchhammer, Elisabetta, Cribioli, Greta Maria Paola, Giordano Attianese, Marcel P, Trefny, Markus, Lenz, Sacha I, Rothschild, Paolo, Strati, Marco, Künzli, Claudia, Lotter, Susanne H, Schenk, Philippe, Dehio, Jordan, Löliger, Ludivine, Litzler, David, Schreiner, Victoria, Koch, Nicolas, Page, Dahye, Lee, Jasmin, Grählert, Dmitry, Kuzmin, Anne-Valérie, Burgener, Doron, Merkler, Miklos, Pless, Maria L, Balmer, Walter, Reith, Jörg, Huwyler, Melita, Irving, Carolyn G, King, Alfred, Zippelius, Christoph, Hess
Publikováno v:
Cell. 185(4)
The relevance of extracellular magnesium in cellular immunity remains largely unknown. Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8
Autor:
Daniel Kirchmeier, Nivedya Swarnalekha, Jie Sun, Ludivine C. Litzler, Carolyn G. King, Young Min Son, David Schreiner, Etori Aguiar Moreira, Saadia Iftikhar, Marco Künzli
Publikováno v:
Sci Immunol
Influenza is a deadly and costly infectious disease, even during flu seasons when an effective vaccine has been developed. To improve vaccines against respiratory viruses, a better understanding of the immune response at the site of infection is cruc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353452d36bc9e6e7f023be52829d4375
https://europepmc.org/articles/PMC8063390/
https://europepmc.org/articles/PMC8063390/
Autor:
Jonas Lötscher, Adrià-Arnau Martí i Líndez, Nicole Kirchhammer, Elisabetta Cribioli, Greta Maria Paola Giordano Attianese, Marcel P. Trefny, Markus Lenz, Sacha I. Rothschild, Paolo Strati, Marco Künzli, Claudia Lotter, Susanne H. Schenk, Philippe Dehio, Jordan Löliger, Ludivine Litzler, David Schreiner, Victoria Koch, Nicolas Page, Dahye Lee, Jasmin Grählert, Dmitry Kuzmin, Anne-Valérie Burgener, Doron Merkler, Miklos Pless, Maria L. Balmer, Walter Reith, Jörg Huwyler, Melita Irving, Carolyn G. King, Alfred Zippelius, Christoph Hess
Publikováno v:
Cell. 185:585-602.e29
The relevance of extracellular magnesium in cellular immunity remains largely unknown. Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8+ T��cells, thereby augmenting calc