Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Carolyn Fonte"'
Autor:
Kenneth A. Perkins, Caryn Lerman, Maxine L. Stitzer, Ashok Jain, Carolyn Fonte, K. N. R. Chengappa, Melissa Mercincavage
Publikováno v:
Clinical Pharmacology & Therapeutics. 88:109-114
Brief procedures for evaluating medication efficacy may reveal which candidate drugs warrant further testing in clinical trials and which do not. We previously carried out a study of smoking abstinence, involving the nicotine patch, and established t
Publikováno v:
Psychopharmacology. 210:45-51
Varenicline may aid smoking cessation by attenuating smoking behavior and reward. We compared the effects of varenicline versus placebo on smoking behavior and reward, assessed both prospectively and retrospectively, and related these effects to subs
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 18:2608-2612
Genes coding for nicotinic acetylcholine receptors may influence response to nicotine replacement therapy for smoking cessation. We examined the association of a 3′ untranslated region polymorphism (rs2072661) in the nicotinic acetylcholine recepto
Publikováno v:
Nicotine & Tobacco Research. 11:84-91
INTRODUCTION The time of day in which craving, withdrawal, and other tobacco abstinence symptoms are assessed may moderate the influences of abstinence or medication on those symptoms. METHODS Participants were 209 smokers participating in a 4-week c
Publikováno v:
Nicotine & Tobacco Research. 7:791-800
Smokers often experience the acute effects of cigarette smoking while they are engaged in the light physical activity of routine tasks. However, virtually all laboratory-based research on these effects is conducted under conditions of quiet rest and,
Publikováno v:
Nicotine & Tobacco Research. 6:501-507
The subjective and reinforcing effects of drugs of abuse may depend partly on their rate of onset, with faster acting formulations typically producing stronger effects than slower ones. In this within-subjects study, we examined the acute effects of
Publikováno v:
Nicotine & Tobacco Research. 5:877-884
Nicotine has many acute subjective, physiological, and behavioral effects in humans, some of which may explain why nicotine produces dependence. Individual differences in the magnitude of these effects (i.e., nicotine sensitivity) are of interest to
Autor:
James E. Grobe, Annette Wilson, Debra Gerlach, Carolyn Fonte, Michelle Broge, Rolf G. Jacob, Mark H. Sanders, Christine R. Cherry, Kenneth A. Perkins
Publikováno v:
Psychopharmacology. 158:7-17
Rationale: Long-term exposure to nicotine is associated with chronic tolerance to its acute effects, adaptation that may lead to tobacco dependence. The time course for loss of this tolerance after cessation of exposure is not known in humans but cou
Publikováno v:
Psychopharmacology. 155:163-170
Rationale: Tobacco use during initial experimentation often involves modest nicotine exposure, escalating to larger doses and more frequent exposure with the onset of tobacco dependence. Threshold doses for nicotine discrimination therefore may diffe
Publikováno v:
Experimental and Clinical Psychopharmacology. 9:91-100
Sensitivity in responses to one drug may relate to sensitivity to other drugs, suggesting broad individual differences in characteristic responsivity across drugs. Data from two separate studies of smokers were reanalyzed to examine associations betw