Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Carolyn A. Larabell"'
Autor:
Simon Leclerc, Alka Gupta, Visa Ruokolainen, Jian-Hua Chen, Kari Kunnas, Axel A Ekman, Henri Niskanen, Ilya Belevich, Helena Vihinen, Paula Turkki, Ana J Perez-Berna, Sergey Kapishnikov, Elina Mäntylä, Maria Harkiolaki, Eric Dufour, Vesa Hytönen, Eva Pereiro, Tony McEnroe, Kenneth Fahy, Minna U Kaikkonen, Eija Jokitalo, Carolyn A Larabell, Venera Weinhardt, Salla Mattola, Vesa Aho, Maija Vihinen-Ranta
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1011829 (2024)
Viruses target mitochondria to promote their replication, and infection-induced stress during the progression of infection leads to the regulation of antiviral defenses and mitochondrial metabolism which are opposed by counteracting viral factors. Th
Externí odkaz:
https://doaj.org/article/487e2f24f96c4045ac1e8396fe49fa50
Autor:
Axel Ekman, Jian-Hua Chen, Bieke Vanslembrouck, Valentina Loconte, Carolyn A. Larabell, Mark A. Le Gros, Venera Weinhardt
Publikováno v:
Advanced Photonics Research, Vol 4, Iss 4, Pp n/a-n/a (2023)
Soft X‐ray tomography offers rapid imaging of whole, single cells with a few tens of nanometers spatial resolution without fixation or labeling. Herein, this technique is limited to specimens about 10 μm thick, such that applications of soft X‐r
Externí odkaz:
https://doaj.org/article/34ab2b85a3cf4a76a5ee7c6e7e7cfd72
Autor:
Soumya G. Remesh, Subhash C. Verma, Jian-Hua Chen, Axel A. Ekman, Carolyn A. Larabell, Sankar Adhya, Michal Hammel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
HU is among the most conserved and abundant nucleoid-associated proteins in eubacteria. Here the authors investigate the role of histone-like proteins (HU) in the 3D organization of the bacteria DNA and show via soft X-ray tomography the process of n
Externí odkaz:
https://doaj.org/article/c5ba312025fb45d398cd579a218e4808
Autor:
Jian-Hua Chen, Bieke Vanslembrouck, Valentina Loconte, Axel Ekman, Mirko Cortese, Ralf Bartenschlager, Gerry McDermott, Carolyn A. Larabell, Mark A. Le Gros, Venera Weinhardt
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101176- (2022)
Summary: The protocol describes step-by-step sample preparation, data acquisition, and segmentation of cellular organelles with soft X-ray tomography. It is designed for microscopes built to perform full-rotation data acquisition on specimens in cyli
Externí odkaz:
https://doaj.org/article/2ffd46a8a2e34dd5ae9932cc02244dd6
Autor:
Jian-Hua Chen, Bieke Vanslembrouck, Axel Ekman, Vesa Aho, Carolyn A. Larabell, Mark A. Le Gros, Maija Vihinen-Ranta, Venera Weinhardt
Publikováno v:
Viruses, Vol 14, Iss 12, p 2651 (2022)
Upon infection, viruses hijack the cell machinery and remodel host cell structures to utilize them for viral proliferation. Since viruses are about a thousand times smaller than their host cells, imaging virus-host interactions at high spatial resolu
Externí odkaz:
https://doaj.org/article/7d1f06bf5cef4e51a946d69fcc3a9b36
Autor:
Jingwei Ma, Myan Do, Mark A Le Gros, Charles S Peskin, Carolyn A Larabell, Yoichiro Mori, Samuel A Isaacson
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008356 (2020)
For a chemical signal to propagate across a cell, it must navigate a tortuous environment involving a variety of organelle barriers. In this work we study mathematical models for a basic chemical signal, the arrival times at the nuclear membrane of p
Externí odkaz:
https://doaj.org/article/e684153658db454b9eee17439c2346d5
Autor:
Venera Weinhardt, Jian-Hua Chen, Axel A Ekman, Jessica Guo, Soumya G Remesh, Michal Hammel, Gerry McDermott, Weilun Chao, Sharon Oh, Mark A Le Gros, Carolyn A Larabell
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227601 (2020)
The diversity of living cells, in both size and internal complexity, calls for imaging methods with adaptable spatial resolution. Soft x-ray tomography (SXT) is a three-dimensional imaging technique ideally suited to visualizing and quantifying the i
Externí odkaz:
https://doaj.org/article/3df436e81ff942be8f8daf9bcf191b2d
Autor:
Vesa Aho, Markko Myllys, Visa Ruokolainen, Satu Hakanen, Elina Mäntylä, Jori Virtanen, Veijo Hukkanen, Thomas Kühn, Jussi Timonen, Keijo Mattila, Carolyn A. Larabell, Maija Vihinen-Ranta
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Various types of DNA viruses are known to elicit the formation of a large nuclear viral replication compartment and marginalization of the cell chromatin. We used three-dimensional soft x-ray tomography, confocal and electron microscopy, com
Externí odkaz:
https://doaj.org/article/6fc9b143eefe40759c570e5b44160ee8
Autor:
Fernando Ugarte, Rebekah Sousae, Bertrand Cinquin, Eric W. Martin, Jana Krietsch, Gabriela Sanchez, Margaux Inman, Herman Tsang, Matthew Warr, Emmanuelle Passegué, Carolyn A. Larabell, E. Camilla Forsberg
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 728-740 (2015)
Epigenetic regulation serves as the basis for stem cell differentiation into distinct cell types, but it is unclear how global epigenetic changes are regulated during this process. Here, we tested the hypothesis that global chromatin organization aff
Externí odkaz:
https://doaj.org/article/bb95f6cead0a4c0faa419918bd8984f2
Autor:
Valentina Loconte, Jian‐Hua Chen, Bieke Vanslembrouck, Axel A. Ekman, Gerry McDermott, Mark A. Le Gros, Carolyn A. Larabell
Publikováno v:
The FASEB Journal. 37
Developing in silico models that accurately reflect a whole, functional cell is an ongoing challenge in biology. Current efforts bring together mathematical models, probabilistic models, visual representations, and data to create a multi-scale descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15dd841f007c01586565e469c35c0e5
https://doi.org/10.1096/fj.202200253r
https://doi.org/10.1096/fj.202200253r