Výsledky vyhledávání - "Carolyn A Fairbanks"

Akademický článek

Development of opioid analgesic tolerance in rat to extended-release buprenorphine formulated for laboratory subjects.

Autor: Christina M Larson, Cecilia Barajas, Kelley F Kitto, George L Wilcox, Carolyn A Fairbanks, Cristina D Peterson

Publikováno v: PLoS ONE, Vol 19, Iss 3, p e0298819 (2024)

Buprenorphine in an extended-release formulation intended for use in laboratory subjects is frequently administered to rats to provide extended analgesia without repeated handling. While levels of buprenorphine may persist in serum once extended-rele

Externí odkaz: https://doaj.org/article/8f8b209ddf5c4759a7b57fb4d45318e3

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Akademický článek

Targeting the somatosensory system with AAV9 and AAV2retro viral vectors.

Autor: Alexander G J Skorput, Reshma Gore, Rachel Schorn, Maureen S Riedl, Ezequiel Marron Fernandez de Velasco, Bailey Hadlich, Kelley F Kitto, Carolyn A Fairbanks, Lucy Vulchanova

Publikováno v: PLoS ONE, Vol 17, Iss 3, p e0264938 (2022)

Adeno-associated viral (AAV) vectors allow for site-specific and time-dependent genetic manipulation of neurons. However, for successful implementation of AAV vectors, major consideration must be given to the selection of viral serotype and route of

Externí odkaz: https://doaj.org/article/7d14210960394bd990975f4290eb8eec

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Akademický článek

Intrathecal or intravenous AAV9-IDUA/RGX-111 at minimal effective dose prevents cardiac, skeletal and neurologic manifestations of murine MPS I

Autor: Lalitha R. Belur, Avery K. Huber, Hillary Mantone, Mason Robertson, Miles C. Smith, Andrea D. Karlen, Kelley F. Kitto, Li Ou, Chester B. Whitley, Elizabeth Braunlin, Justin Furcich, Troy C. Lund, Davis Seelig, Carolyn A. Fairbanks, Nicholas Buss, Kwi Hye Kim, R. Scott McIvor

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101369- (2024)

Mucopolysaccharidosis type I (MPS I) is a rare metabolic disorder caused by deficiency of α-L-iduronidase (IDUA), resulting in glycosaminoglycan (GAG) accumulation and multisystemic disease. Current treatments include hematopoietic stem cell transpl

Externí odkaz: https://doaj.org/article/03d89651f88d4d478f8e98a618f31356

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Akademický článek

Morphine and clonidine combination therapy improves therapeutic window in mice: synergy in antinociceptive but not in sedative or cardiovascular effects.

Autor: Laura S Stone, Jonathan P German, Kelly F Kitto, Carolyn A Fairbanks, George L Wilcox

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109903 (2014)

Opioids are used to manage all types of pain including acute, cancer, chronic neuropathic and inflammatory pain. Unfortunately, opioid-related adverse effects such as respiratory depression, tolerance, physical dependence and addiction have led to an

Externí odkaz: https://doaj.org/article/41780ada46b94de19e1f2cd66db5186f

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Akademický článek

Effect of chronic pain on fentanyl self-administration in mice.

Autor: Carrie L Wade, Perry Krumenacher, Kelley F Kitto, Cristina D Peterson, George L Wilcox, Carolyn A Fairbanks

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79239 (2013)

The development of opioid addiction in subjects with established chronic pain is an area that is poorly understood. It is critically important to clearly understand the neurobiology associated with propensity toward conversion to addiction under cond

Externí odkaz: https://doaj.org/article/06f4520ed5b64356a5063109df35945d

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