Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Carolyn A, Carr"'
Autor:
Colleen A. Lopez, Heba Hussain A. A. Al-Siddiqi, Ujang Purnama, Sonia Iftekhar, Arne A. N. Bruyneel, Matthew Kerr, Rabia Nazir, Maria da Luz Sousa Fialho, Sophia Malandraki-Miller, Rita Alonaizan, Fatemeh Kermani, Lisa C. Heather, Jan Czernuszka, Carolyn A. Carr
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human cardiac cells to be studied in vitro, although they use glucose as their primary metabolic substrate and do not recapitulate the properties of adult cardiomy
Externí odkaz:
https://doaj.org/article/620b82f11a04444ebfe740c6e09d998a
Publikováno v:
Metabolites, Vol 12, Iss 9, p 832 (2022)
Diabetes is a global epidemic, with cardiovascular disease being the leading cause of death in diabetic patients. There is a pressing need for an in vitro model to aid understanding of the mechanisms driving diabetic heart disease, and to provide an
Externí odkaz:
https://doaj.org/article/4f00e25cd46e48f79ebd754452cc1485
Autor:
Khadijeh Kathy Pakzad, Jun Jie Tan, Stephanie Anderson, Mary Board, Kieran Clarke, Carolyn A. Carr
Publikováno v:
Stem Cell Research, Vol 54, Iss , Pp 102422- (2021)
Cardiosphere-derived cells (CDCs) can be expanded in vitro and induced to differentiate along the cardiac lineage. To recapitulate the phenotype of an adult cardiomyocyte, differentiating progenitors need to upregulate mitochondrial glucose and fatty
Externí odkaz:
https://doaj.org/article/f0ec3124754045e0a60432db138d9e0e
Autor:
Sophia Malandraki-Miller, Colleen A. Lopez, Rita Alonaizan, Ujang Purnama, Filippo Perbellini, Kathy Pakzad, Carolyn A. Carr
Publikováno v:
Stem Cell Research, Vol 38, Iss , Pp - (2019)
Myocardial infarction is the most prevalent of cardiovascular diseases and pharmacological interventions do not lead to restoration of the lost cardiomyocytes. Despite extensive stem cell therapy studies, clinical trials using cardiac progenitor cell
Externí odkaz:
https://doaj.org/article/e4091b63c12945408de1ba49db730608
Autor:
Christakis Constantinides, Mahon Maguire, Eileen McNeill, Ricardo Carnicer, Edyta Swider, Mangala Srinivas, Carolyn A Carr, Jurgen E Schneider
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225786 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0190558.].
Externí odkaz:
https://doaj.org/article/2d55bff9fda94ee6b308151b567dd62f
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
The heart is a metabolic omnivore and the adult heart selects the substrate best suited for each circumstance, with fatty acid oxidation preferred in order to fulfill the high energy demand of the contracting myocardium. The fetal heart exists in an
Externí odkaz:
https://doaj.org/article/eefbb8d790cf4c8eb99f8d1f8a1bd513
Autor:
Christakis Constantinides, Mahon Maguire, Eileen McNeill, Ricardo Carnicer, Edyta Swider, Mangala Srinivas, Carolyn A Carr, Jurgen E Schneider
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190558 (2018)
PurposeTo a) achieve cardiac 19F-Magnetic Resonance Imaging (MRI) of perfluoro-crown-ether (PFCE) labeled cardiac progenitor stem cells (CPCs) and bone-derived bone marrow macrophages, b) determine label concentration and cellular load limits, and c)
Externí odkaz:
https://doaj.org/article/e5b276cbc9484c30a323c2f421bc712f
Autor:
Suat Cheng Tan, Renata S. M. Gomes, Kar Kheng Yeoh, Filippo Perbellini, Sophia Malandraki-Miller, Lucy Ambrose, Lisa C. Heather, Giuseppe Faggian, Christopher J. Schofield, Kay E. Davies, Kieran Clarke, Carolyn A. Carr
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Cardiosphere-derived cells (CDCs), which can be isolated from heart explants, are a promising candidate cell source for infarcted myocardium regeneration. However, current protocols used to expand CDCs require at least 1 month in vitro to obtain suff
Externí odkaz:
https://doaj.org/article/49b7d846cf104520ba3cf4554d037903
Autor:
Colleen Lopez, William Fuller, Jack J. Miller, Kieran Clarke, Georgina Berridge, Roman Fischer, S Rohling, K.M.J.H. Dennis, C.L. Aitken, Matthew Kerr, Carolyn A. Carr, Lisa C. Heather, Damian J. Tyler
Publikováno v:
The FASEB Journal
Kerr, M, Dennis, K M J H, Carr, C A, Fuller, W, Berridge, G, Rohling, S, Aitken, C L, Lopez, C, Fischer, R, Miller, J J, Clarke, K, Tyler, D J & Heather, L C 2021, ' Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia ', FASEB Journal, vol. 35, no. 8, e21765 . https://doi.org/10.1096/fj.202100394R
Kerr, M, Dennis, K M J H, Carr, C A, Fuller, W, Berridge, G, Rohling, S, Aitken, C L, Lopez, C, Fischer, R, Miller, J J, Clarke, K, Tyler, D J & Heather, L C 2021, ' Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia ', FASEB Journal, vol. 35, no. 8, e21765 . https://doi.org/10.1096/fj.202100394R
The bioactive lipid intermediate palmitoyl CoA (PCoA) can inhibit mitochondrial ADP/ATP transport, though the physiological relevance of this regulation remains unclear. We questioned whether myocardial ischemia provides a pathological setting in whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9291e196f652495888da50c5d314b9a2
https://doi.org/10.1096/fj.202100394r
https://doi.org/10.1096/fj.202100394r
Autor:
Mala Gunadasa-Rohling, Robin P. Choudhury, Rafik Salama, Daniela Pezzolla, Carolyn A. Carr, Eleonor Price, Christopher W. Pugh, Elisabetta Gamen, Paul R. Riley, Carla De Villiers, Tammie Bishop, David R. Mole, Joaquim M. Vieira
In humans, new-born infants have the ability to regenerate their heart during early life. This is modelled in the mouse, where regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this process holds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50e823f8806863fd80e08c29d6d6f003
https://doi.org/10.21203/rs.3.rs-569151/v1
https://doi.org/10.21203/rs.3.rs-569151/v1
