Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Carolyn, Whitsett"'
Autor:
Mario Falchi, Lilian Varricchio, Fabrizio Martelli, Francesca Masiello, Giulia Federici, Maria Zingariello, Gabriella Girelli, Carolyn Whitsett, Emanuel F. Petricoin, Søren Kragh Moestrup, Ann Zeuner, Anna Rita Migliaccio
Publikováno v:
Haematologica, Vol 100, Iss 2 (2015)
Cultures of human CD34pos cells stimulated with erythroid growth factors plus dexamethasone, a model for stress erythropoiesis, generate numerous erythroid cells plus a few macrophages (approx. 3%; 3:1 positive and negative for CD169). Interactions o
Externí odkaz:
https://doaj.org/article/32d76d3a272c46e5b9a67bd0a649b96b
Publikováno v:
Stem Cells International, Vol 2012 (2012)
The primary focus of national blood programs is the provision of a safe and adequate blood supply. This goal is dependent on regular voluntary donations and a regulatory infrastructure that establishes and enforces standards for blood safety. Progres
Externí odkaz:
https://doaj.org/article/ad9d142e8e074c65bd303902bfe6c06c
Autor:
Barbara Ghinassi, Leda Ferro, Francesca Masiello, Valentina Tirelli, Massimo Sanchez, Giovanni Migliaccio, Carolyn Whitsett, Stefan Kachala, Isabelle Riviere, Michel Sadelain, Anna Rita Migliaccio
Publikováno v:
Stem Cells International, Vol 2011 (2011)
Ex vivo expanded erythroblasts (EBs) may serve as advanced transfusion products provided that lodgment occurs in the macrophage-niche of the marrow permitting maturation. EBs expanded from adult and cord blood expressed the receptors (CXCR4, VLA-4, a
Externí odkaz:
https://doaj.org/article/33fafcce1aa74af29415a67ab81bcca4
Autor:
Valentina Tirelli, Barbara Ghinassi, Anna Rita Migliaccio, Carolyn Whitsett, Francesca Masiello, Massimo Sanchez, Giovanni Migliaccio
Publikováno v:
Stem Cells International, Vol 2011 (2011)
In Human Erythroid Massive Amplification (HEMA) cultures, AB mononuclear cells (MNC) generate 1-log more erythroid cells (EBs) than the corresponding CD34pos cells, suggesting that MNC may also contain CD34neg HPC. To clarify the phenotype of AB HPC
Externí odkaz:
https://doaj.org/article/c19d3f346e7d4b5abc63c8a1e922798d
Autor:
Giovanni Migliaccio, Massimo Sanchez, Francesca Masiello, Valentina Tirelli, Lilian Varricchio, Carolyn Whitsett, Anna Rita Migliaccio
Publikováno v:
Cell Transplantation, Vol 19 (2010)
Ex vivo-generated erythroblasts represent alternative transfusion products. However, inclusion of bovine components in media used for their growth precludes clinical use, highlighting the importance of developing culture media based on pharmaceutical
Externí odkaz:
https://doaj.org/article/64cc8bbd53c54e91b32a6a54694128af
Autor:
Ghazala Hashmi, Francesca Masiello, Massimo Sanchez, Anna Rita Migliaccio, Paolo Rebulla, Maria Antonietta Villa, Carolyn Whitsett, Girelli Gabriella, Valentina Tirelli, Emile van den Akker, Maurizio Marconi
Publikováno v:
Transfusion. 54:1059-1070
Background Cultured red blood cells (cRBCs) from cord blood (CB) have been proposed as transfusion products. Whether buffy coats discarded from blood donations (adult blood [AB]) may be used to generate cRBCs for transfusion has not been investigated
Autor:
Fabrizio Martelli, Carolyn Whitsett, Giulia Federici, Anna Rita Migliaccio, Stefania Vaglio, Ann Zeuner
Publikováno v:
STEM CELLS. 30:1587-1596
Blood transfusions have become indispensable to treat the anemia associated with a variety of medical conditions ranging from genetic disorders and cancer to extensive surgical procedures. In developed countries, the blood supply is generally adequat
Autor:
James Godbold, Barbara Ghinassi, Elena Alfani, Elena Masselli, Anna Rita Migliaccio, Ronald Hoffman, Alessandro M. Vannucchi, Carolyn Whitsett, Wenyong Zhang, Angela Battistini, Lilian Varricchio, Damiano Rondelli, Giovanni Migliaccio
Publikováno v:
Blood. 118:425-436
Glucocorticoid receptor (GR) agonists increase erythropoiesis in vivo and in vitro. To clarify the effect of the dominant negative GRβ isoform (unable to bind STAT-5) on erythropoiesis, erythroblast (EB) expansion cultures of mononuclear cells from
Publikováno v:
Chemistry and Biochemistry of Oxygen Therapeutics
Autor:
Valentina Tirelli, Anna Rita Migliaccio, Vesna Najfeld, Amanda LeBlanc, Giovanni Migliaccio, Carolyn Whitsett, Massimo Sanchez, Francesca Masiello
Publikováno v:
Transfusion. 49:2668-2679
BACKGROUND: Cultured human erythroid cells derived in vitro may represent alternative transfusion products. It is unknown, however, if these ex vivo expanded erythroid cells remain functional or develop genetic abnormalities after storage. STUDY DESI