Zobrazeno 1 - 10
of 1 488
pro vyhledávání: '"Carolyn, Jones"'
Autor:
Peter S. McPherson, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Walaa Alshalfie, Harvinder Virk, Zhipeng You, Carolyn Jones, Michael Biddle
Publikováno v:
F1000Research, Vol 12 (2024)
RNA-binding protein Fused-in Sarcoma (FUS) plays an essential role in various cellular processes. Mutations in the C-terminal domain region, where the nuclear localization signal (NLS) is located, causes the redistribution of FUS from the nucleus to
Externí odkaz:
https://doaj.org/article/64d8deecdefb4a53ac5fa2837cb1e422
Autor:
Carl Laflamme, Kathleen Southern, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Harvinder Virk, Carolyn Jones, Michael S. Biddle
Publikováno v:
F1000Research, Vol 13 (2024)
Synaptotagmin-1 is a synaptic vesicle transmembrane protein that senses calcium influx via its tandem C2-domains, triggering synchronous neurotransmitter release. Disruption to SYT1 is associated with neurodevelopmental disorders, highlighting the im
Externí odkaz:
https://doaj.org/article/3a714eae297445a9a3cc323e3a153d08
Autor:
Sara Busacca, Qi Zhang, Annabel Sharkey, Alan G. Dawson, David A. Moore, David A. Waller, Apostolos Nakas, Carolyn Jones, Kelvin Cain, Jin-li Luo, Adriana Salcedo, Iris Chiara Salaroglio, Chiara Riganti, John Le Quesne, Tom John, Paul C. Boutros, Shu-Dong Zhang, Dean A. Fennell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase (MTAP) deletion, s
Externí odkaz:
https://doaj.org/article/6d5abf6e1ac14ad9997c92268bf3d48f
Publikováno v:
International Journal of Reproductive BioMedicine, Vol 18, Pp 539-550 (2020)
Background: Infertility is a common problem in testicular cancer. Affected men often decide to undergo sperm banking before chemo/radiotherapy. The cumulative effects of therapy can considerably reduce fertility. Objective: Testicular cancers impair
Externí odkaz:
https://doaj.org/article/5aec8537501540db976daeaff673aa5e
Autor:
Rebecca C Allsopp, Caroline M Cowley, Ruth C Barber, Carolyn Jones, Christopher W Holmes, Paul W Bird, Shailesh G Gohil, Claire Blackmore, Martin D Tobin, Nigel Brunskill, Philip N Baker, Jacqui A Shaw
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273912 (2022)
PurposeTo demonstrate the diagnostic performance of rapid SARS-CoV-2 RT-LAMP assays, comparing the performance of genomic versus sub-genomic sequence target with subsequent application in an asymptomatic screening population.MethodsRT-LAMP diagnostic
Externí odkaz:
https://doaj.org/article/5cd4c4f3e2524e02a11cdb6fd177236a
Publikováno v:
Journal of Primary Care & Community Health, Vol 12 (2021)
Context: Increasing rates of Opioid Use Disorder among pregnant women are a significant public health issue. Care for these women is fragmented, and multiple barriers to care have been identified. Program: The Tides, Inc. is attempting to address the
Externí odkaz:
https://doaj.org/article/921d79a70e7b47fd9a3c9393d3024b20
Autor:
James H. Willig, Jennifer Croker, Lisa McCormick, Meena Nabavi, Jeremey Walker, Nancy P. Wingo, Cathy C. Roche, Carolyn Jones, Katherine E. Hartmann, David Redden
Publikováno v:
Journal of Clinical and Translational Science, Vol 5 (2021)
Leveraging elements of game design and theories of human motivation, gamification provides a variety of techniques to engage learners in novel ways. Our Clinical and Translational Science Award created the software platform (Kaizen-Education©) to de
Externí odkaz:
https://doaj.org/article/65680d9d155445c384e3306d5e40eee4
Autor:
Larissa Lezina, Ruth V. Spriggs, Daniel Beck, Carolyn Jones, Kate M. Dudek, Aleksandra Bzura, George D.D. Jones, Graham Packham, Anne E. Willis, Simon D. Wagner
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 1869-1881 (2018)
Abstract: CD40L/interleukin-4 (IL-4) stimulation occurs in vivo in the tumor microenvironment and induces global translation to varying degrees in individuals with chronic lymphocytic leukemia (CLL) in vitro. However, the implications of CD40L/IL-4 f
Externí odkaz:
https://doaj.org/article/e2974f59adb3490f8717a12a506921bd
Publikováno v:
BMC Medical Genetics, Vol 18, Iss 1, Pp 1-5 (2017)
Abstract Background Diagnostic Exome Sequencing (DES) has been shown to be an effective tool for diagnosis individuals with suspected genetic conditions. Case Presentation We report a male infant born with multiple anomalies including bilateral dyspl
Externí odkaz:
https://doaj.org/article/3b4a8130ebde489a9e0710d09cf2e8ab
Autor:
Avram Fraint, Bichun Ouyang, Leonard Verhagen Metman, Carolyn Jones, Deborah A. Hall, Karen Marder, Gian Pal
Publikováno v:
Parkinson's Disease, Vol 2019 (2019)
Objectives. As genetic testing is becoming more widely commercially available for Parkinson’s disease (PD) and may have implications regarding clinical outcomes for deep brain stimulation (DBS) and other therapies, we aimed to determine patient kno
Externí odkaz:
https://doaj.org/article/793004dd5bc44795b45aa392d9077f86