Miltefosine-loaded lipid nanoparticles: Improving miltefosine stability and reducing its hemolytic potential toward erythtocytes and its cytotoxic effect on macrophages

Autor: Claudete J. Valduga, Marcia M Dos Santos, José Jardes da Gama Bitencourt, Carolline de Paula Pinto, Thales Henrique Santos Guimarães, Marina Berardi Barioni, Wallance Moreira Pazin, Maria Aparecida Gonçalves dos Santos, Amando Siuiti Ito

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The toxic effects of miltefosine on the epithelial cells of the gastrointestinal tract and its hemolytic action on erythrocytes have limited its use as an antileishmanial agent. As part of our search for new strategies to overcome the side effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f6a0dd56d55bb1218f006d45912f64
https://doi.org/10.1016/j.bpc.2016.07.005