Výsledky vyhledávání - "Caroline. J. Small"

Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance

Autor: David Jl Gunner, Caroline J. Small, Nina M. Semjonous, James R.C. Parkinson, Stephen R. Bloom, Kirsty L. Smith, Kevin Murphy, Yong-Ling Liu, Mohammad A. Ghatei

Publikováno v: International journal of obesity (2005)

The hypothalamic control of energy balance is regulated by a complex network of neuropeptide-releasing neurons. Although the effect of these neuropeptides on individual aspects of energy homoeostasis has been studied, the coordinated response of thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2044ab5b85b77657b05d9827986090
https://doi.org/10.1038/ijo.2009.96

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PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones

Autor: Stephen R. Bloom, Iain Pritchard, James R.C. Parkinson, Waljit S. Dhillo, Caroline J. Small, Owais B. Chaudhri, M. A. Ghatei, Stanley Moore, Gavin A. Bewick

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 294:E698-E708

Peptide YY (PYY) is secreted postprandially from the endocrine L cells of the gastrointestinal tract. PYY3-36, the major circulating form of the peptide, is thought to reduce food intake in humans and rodents via high-affinity binding to the autoinhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b164eb03ae1a4bdcdde872f1f706013
https://doi.org/10.1152/ajpendo.00405.2007

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Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial

Autor: Karim Meeran, S.R. Bloom, Caroline J. Small, Katie Wynne, M. A. Ghatei, Gary Frost, Adrian Park

Publikováno v: International Journal of Obesity. 30:1729-1736

Oxyntomodulin has recently been found to decrease body-weight in obese humans and may be a potential anti-obesity therapy.To determine whether oxyntomodulin alters energy expenditure, in addition to reducing energy intake, in 'free-living' overweight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f01d2ab192189d45498431baa3df96
https://doi.org/10.1038/sj.ijo.0803344

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Interactions between the melanocortin system and the hypothalamo–pituitary–thyroid axis

Autor: Kirsty L. Smith, Niamh M. Martin, Caroline J. Small, Stephen R. Bloom

Publikováno v: Peptides. 27:333-339

Recent studies of transgenic mice and humans have provided compelling evidence for the importance of the hypothalamic melanocortin system in the regulation of energy balance. Energy homeostasis is a balance between food intake (energy input) and ener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b41c0afb7e1e373c3857426fe6bd50
https://doi.org/10.1016/j.peptides.2005.01.028

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The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat

Autor: S.R. Bloom, L L Broadhead, M. A. Ghatei, Kirsty L. Smith, Caroline J. Small, Caroline R. Abbott, A Sajedi, James R.C. Parkinson

Publikováno v: International Journal of Obesity. 30:288-292

Peptide YY3-36 (PYY(3-36)), glucagon-like peptide-1 (GLP-1), oxyntomodulin and cholecystokinin (CCK) are gastrointestinal-derived hormones that are released postprandially in proportion to the amount of calories ingested. All significantly reduce foo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44624b98323611081d2e44b0bb52e556
https://doi.org/10.1038/sj.ijo.0803137

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Abnormalities of the somatotrophic axis in the obese agouti mouse

Autor: D F Carmignac, P A Houston, A Sajedi, M. A. Ghatei, S.R. Bloom, Niamh M. Martin, Caroline J. Small, Michael Patterson

Publikováno v: International Journal of Obesity. 30:430-438

Abnormalities of the melanocortin system produce obesity and increased linear growth. While the obesity phenotype is well characterised, the mechanism responsible for increased linear growth is unclear. The somatotrophic axis was studied in the obese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0f6a7201639f1f9655b4221659f79a
https://doi.org/10.1038/sj.ijo.0803076

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The gastrointestinal tract and the regulation of appetite

Autor: Caroline J. Small, Owais B. Chaudhri, Stephen R. Bloom

Publikováno v: Drug Discovery Today: Disease Mechanisms. 2:289-294

The increasing incidence of obesity worldwide has renewed interest in the control of food intake and energy homeostasis. The brain–gut axis is central to the mechanism by which the periphery signals energy status to central nervous appetite centres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::727eb454ed63bd370b603e49d73fb1bc
https://doi.org/10.1016/j.ddmec.2005.08.002

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Subcutaneous Oxyntomodulin Reduces Body Weight in Overweight and Obese Subjects

Autor: Caroline J. Small, Mohammad A. Ghatei, Katie Wynne, Kevin G. Murphy, Michael Patterson, Karim Meeran, Sandra M. Ellis, Gary Frost, Stephen R. Bloom, Adrian Park, Alison M. Wren

Publikováno v: Diabetes. 54:2390-2395

This study investigated the effect of subcutaneously administered oxyntomodulin on body weight in healthy overweight and obese volunteers. Participants self-administered saline or oxyntomodulin subcutaneously in a randomized, double-blind, parallel-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::489646f262573892bf6f47c62b7db284
https://doi.org/10.2337/diabetes.54.8.2390

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Ghrelin Does Not Stimulate Food Intake in Patients with Surgical Procedures Involving Vagotomy

Autor: A. M. Martinez-Isla, T. J. Halsey, C. W. le Roux, M. A. Ghatei, Caroline J. Small, S.R. Bloom, Nicola M. Neary, N. A. Theodorou

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 90:4521-4524

Patients with gastric or esophageal surgery and transection of the vagus nerve may suffer from appetite and weight loss but without dysphagia or mechanical obstruction to eating. The gastric hormone ghrelin stimulates food intake and GH release in ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f91ead6c1aac204453b61db2eed2a4
https://doi.org/10.1210/jc.2004-2537

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Subcutaneous Ghrelin Enhances Acute Food Intake in Malnourished Patients Who Receive Maintenance Peritoneal Dialysis

Autor: Edwina A. Brown, Kalli Giannitsopoulou, Mohammad A. Ghatei, Gary Frost, Caroline J. Small, Peter Choi, Stephen R. Bloom, Katie Wynne, Michael Patterson

Publikováno v: Journal of the American Society of Nephrology. 16:2111-2118

Anorexia and malnutrition confer significant morbidity and mortality to patients with end-stage kidney disease but are resistant to therapy. The aim of this study was to determine whether subcutaneous administration of ghrelin, an appetite-stimulatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38513dd7cd751c0e81dd0c8c0cb0b9c
https://doi.org/10.1681/asn.2005010039

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