Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Caroline von Achenbach"'
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Akademický článek
Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02
Autor: Caroline von Achenbach, Emilie Le Rhun, Felix Sahm, Sophie S. Wang, Philipp Sievers, Marian C. Neidert, Elisabeth J. Rushing, Tracy Lawhon, Hannah Schneider, Andreas von Deimling, Michael Weller
Publikováno v: Translational Oncology, Vol 13, Iss 12, Pp 100852- (2020)
Standards of care for meningioma include surgical resection and radiotherapy whereas pharmacotherapy plays almost no role in this disease. We generated primary cultures from surgically removed meningiomas to explore the activity of a novel cyclin-dep
Externí odkaz: https://doaj.org/article/145fbd649c5945998dcc919fa95ddefa
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2
Data from Depatuxizumab Mafodotin (ABT-414)-induced Glioblastoma Cell Death Requires EGFR Overexpression, but not EGFRY1068 Phosphorylation
Autor: Michael Weller, William A. Weiss, Vincent Blot, Manuela Silginer, Caroline von Achenbach
Glioblastomas commonly (40%) exhibit epidermal growth factor receptor (EGFR) amplification; half of these tumors carry the EGFRvIII deletion variant characterized by an in-frame deletion of exons 2–7, resulting in constitutive EGFR activation. Alth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dda0127ee8fb579c903b7efdbca6049
https://doi.org/10.1158/1535-7163.c.6543109.v1
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5
The Choice between Intravenous and Subcutaneous Immunoglobulins: Aspects for Consideration
Autor: Caroline von Achenbach, Giselle Hevia Hernandez, Stephan von Gunten
Publikováno v: Pharmacology. 107:556-563
Background: Intravenous immunoglobulin and subcutaneous immunoglobulin preparations are used to treat primary and secondary immunodeficiencies, as well as autoimmune and inflammatory conditions. Summary: For certain indications, only defined formulat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfbdffcbcb79a5e0b01e044e02b41b6
https://doi.org/10.1159/000527655
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6
Depatuxizumab Mafodotin (ABT-414)-induced Glioblastoma Cell Death Requires EGFR Overexpression, but not EGFRY1068 Phosphorylation
Autor: Vincent Blot, William A. Weiss, Michael Weller, Manuela Silginer, Caroline von Achenbach
Publikováno v: Molecular Cancer Therapeutics. 19:1328-1339
Glioblastomas commonly (40%) exhibit epidermal growth factor receptor (EGFR) amplification; half of these tumors carry the EGFRvIII deletion variant characterized by an in-frame deletion of exons 2–7, resulting in constitutive EGFR activation. Alth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::554e9b01b48e8ca90c7d47d66dbad6af
https://doi.org/10.1158/1535-7163.mct-19-0609
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7
Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02
Autor: Elisabeth J. Rushing, Tracy Lawhon, Felix Sahm, Marian Christoph Neidert, Andreas von Deimling, Michael Weller, Caroline von Achenbach, Hannah Schneider, Philipp Sievers, Sophie S. Wang, Emilie Le Rhun
Publikováno v: Translational Oncology, Vol 13, Iss 12, Pp 100852-(2020)
Translational Oncology
Translational Oncology, 2020, Translational Oncology, 13 (12), pp.100852. ⟨10.1016/j.tranon.2020.100852⟩
Standards of care for meningioma include surgical resection and radiotherapy whereas pharmacotherapy plays almost no role in this disease. We generated primary cultures from surgically removed meningiomas to explore the activity of a novel cyclin-dep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf969050865b37054dc82439e329bd1
https://doi.org/10.5167/uzh-191423
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8
Synergistic growth inhibition mediated by dual PI3K/mTOR pathway targeting and genetic or direct pharmacological AKT inhibition in human glioblastoma models
Autor: Caroline von Achenbach, Doriano Fabbro, Dorothee Gramatzki, Emese Szabo, Kerstin Kaulich, Guido Reifenberger, Angela Zacher, Michael Weller
Molecular genetic aberrations in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway are common in human cancers including glioblastoma, yet, novel therapeutic approaches targeting this pathway in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85694ec50ab80a4520c104351486aba6
https://www.zora.uzh.ch/id/eprint/176282/
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9
CSIG-06. DEPATUXIZUMAB MAFODOTIN (ABT-414)-INDUCED GLIOBLASTOMA CELL DEATH REQUIRES EGFR OVEREXPRESSION, BUT NOT PHOSPHORYLATION
Autor: William A. Weiss, Vincent Blot, Michael Weller, Caroline von Achenbach
Publikováno v: Neuro Oncol
Glioblastomas commonly (40%) exhibit epidermal growth factor receptor (EGFR) amplification, half of these tumors carry the EGFRvIII deletion variant characterized by an in-frame deletion of exons 2–7, resulting in constitutive EGFR activation. Alth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bad3ce66471d5000952164f389552f
https://europepmc.org/articles/PMC6847073/
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10
Profound, durable and MGMT‐independent sensitivity of glioblastoma cells to cyclin‐dependent kinase inhibition
Autor: Hannah Schneider, Caroline von Achenbach, Emese Szabo, Michael Weller, Birthe Lohmann, Emilie Le Rhun, Manuela Silginer, Kristan Meetze
Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2019, 145 (1), pp.242-253. ⟨10.1002/ijc.32069⟩
International audience; TG02 is a novel cyclin-dependent kinase (CDK) inhibitor and thought to act mainly via CDK-9 inhibition-dependent depletion of short-lived oncoproteins such as MCL-1 or c-MYC. We studied the activity of TG02 in 9 human long-ter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114a775717811f157387e7d5249be5ec
https://www.hal.inserm.fr/inserm-02941519/file/ijc.32069.pdf
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