Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Caroline Wechsler"'
Autor:
Francisca Vazquez, Iris Fung, Aviad Tsherniak, Thomas P. Howard, Brenton R. Paolella, Adam D. Durbin, Pratiti Bandopadhayay, Allison Warren, Charles W. M. Roberts, Andrew Tang, Andrew L. Hong, Clare F. Malone, James M. McFarland, Joshua M. Dempster, William C. Hahn, John M. Krill-Burger, Phoebe Moh, Caroline Wechsler, Lillian M. Guenther, Jesse S. Boehm, Philip Montgomery, Guillaume Kugener, Nishant Jha, Neekesh V. Dharia, Todd R. Golub, Kimberly Stegmaier
Publikováno v:
Nature genetics
Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-burden adult cancers. A key question, however, is whether functional genomic approaches will yield new targets in pediatric cancers, known for remarkably few mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6893618c37ed2d2cf2c51d0c0e13ea
http://europepmc.org/articles/PMC8049517
http://europepmc.org/articles/PMC8049517
Autor:
Joseph D. Mancias, Amanda L. Robichaud, Jerome Tamburini, Clément Larrue, Federica Piccioni, Lynn Lee, Anthony Letai, Jeremy Ryan, Shan Lin, Amy Saur Conway, Nastassja K. Scheidegger, Mark Wunderlich, Scott T. Younger, Biniam Adane, Sarah Mouche, Neekesh V. Dharia, Guillaume Kugener, Bo Kyung A. Seong, Thelma Mashaka, Kimberly Stegmaier, Miljan Kuljanin, Caroline Wechsler
Publikováno v:
Cancer Discov
CRISPR–Cas9-based genetic screens have successfully identified cell type–dependent liabilities in cancer, including acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival. Because most of these screens have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c56bc6680b50eddcd2ed9826b4c7ab
Autor:
Amy Saur Conway, Miljan Kuljanin, Joseph D. Mancias, Sarah Mouche, Shan Lin, Scott T. Younger, Biniam Adane, Lynn Lee, Mark Wunderlich, Federica Piccioni, Amanda L. Robichaud, Jerome Tamburini, Guillaume Kugener, Bo Kyung A. Seong, Anthony Letai, Clement Larrue, Caroline Wechsler, Thelma Mashaka, Jeremy Ryan, Neekesh V. Dharia, Kimberly Stegmaier
CRISPR-Cas9-based genetic screens have successfully identified cell type-dependent liabilities in cancers, including acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival. Because most of these screens have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea3b4a8acc172ebb9484c620b520f391
https://doi.org/10.1101/2020.12.28.424340
https://doi.org/10.1101/2020.12.28.424340
Autor:
Caroline Wechsler, Nia Brown, Rebecca Ssengonzi, Christoph P. Hornik, Keyaria D. Gray, Reese H. Clark, Daniel Gonzalez, Olivia M. Bretzius, James A. Fitz-Henley, P. Brian Smith, Mihai Puia-Dumitrescu, Daniel K. Benjamin
Publikováno v:
The Journal of Pediatrics. 203:131-136
Objective To characterize the association between gentamicin dosing, duration of treatment, and ototoxicity in hospitalized infants. Study design This retrospective cohort study conducted at 330 neonatal intensive care units (2002-2014) included inbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525e3211cc80e7f9d2829b7c93db7e41
https://doi.org/10.1016/j.jpeds.2018.07.101
https://doi.org/10.1016/j.jpeds.2018.07.101
Autor:
Kimberly Stegmaier, Federica Piccioni, Caroline Wechsler, Amy Saur Conway, Shan Lin, Scott T. Younger, Mark Wunderlich, Biniam Adane, Neekesh V. Dharia, Amanda L Robinchaud, Gabriela Alexe, Nastassja K. Scheidegger, Lynn Lee, Guillaume Kugener, Bo Kyung A. Seong
Publikováno v:
Blood. 138:3319-3319
Metabolic reprogramming contributes to tumor development and sustains cancer cell proliferation. Like other cancers, acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival, has altered metabolic features, provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a33859e4cc0f18a82d35249640badaa
https://doi.org/10.1182/blood-2021-152023
https://doi.org/10.1182/blood-2021-152023
Autor:
Federica Piccioni, Amy Saur Conway, Nastassja K. Scheidegger, Mark Wunderlich, Scott T. Younger, Biniam Adane, Shan Lin, Neekesh V. Dharia, Kimberly Stegmaier, Guillaume Kugener, Bo Kyung A. Seong, Jerome Tamburini, Amanda L Robinchaud, Caroline Wechsler, Lynn Lee, Clement Larrue
Publikováno v:
Blood. 138:266-266
First-generation, large-scale functional genomic screens have revealed hundreds of potential genetic vulnerabilities in acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival. Because these large-scale genetic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a41fcb9fad8fbe062412c13a7ee3d3c
https://doi.org/10.1182/blood-2021-153039
https://doi.org/10.1182/blood-2021-153039
Autor:
Crystal McKnight, Jaume Mora, Jesse S. Boehm, Kimberly Stegmaier, Amy Goodale, Neekesh V. Dharia, Jerrel L Catlett, Gabriela Alexe, Linda Ross, Elizabeth S. Frank, Federica Piccioni, Amanda L. Robichaud, Mindy I. Davis, Alanna J. Church, Lillian M. Guenther, Caroline Wechsler, Katherine A. Janeway, Amy Saur Conway, Rajarshi Guha, Yuen-Yi Tseng
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(4)
Purpose: Novel targeted therapeutics have transformed the care of subsets of patients with cancer. In pediatric malignancies, however, with simple tumor genomes and infrequent targetable mutations, there have been few new FDA-approved targeted drugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d0a405af48368bea6dd17ddb3860cb
https://pubmed.ncbi.nlm.nih.gov/30397176
https://pubmed.ncbi.nlm.nih.gov/30397176