The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling

Autor: Suhaini Sudi, Fiona Macniesia Thomas, Siti Kadzirah Daud, Dayang Maryama Ag Daud, Caroline Sunggip

Publikováno v: Molecules, Vol 28, Iss 5, p 2102 (2023)

Myocardial remodelling is a molecular, cellular, and interstitial adaptation of the heart in response to altered environmental demands. The heart undergoes reversible physiological remodelling in response to changes in mechanical loading or irreversi

Externí odkaz: https://doaj.org/article/1a9ffcca4088498387f15a394280c6d8

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy

Autor: Caroline Sunggip, Kakeru Shimoda, Sayaka Oda, Tomohiro Tanaka, Kazuhiro Nishiyama, Supachoke Mangmool, Akiyuki Nishimura, Takuro Numaga-Tomita, Motohiro Nishida

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure. These ligands can induce hypertrophic growth of neonatal rat cardiomyocytes (NRCMs) mainly through Ca2+

Externí odkaz: https://doaj.org/article/a4753e6a469d4c0698a6960a9822ea14

Modulation of POPDC1 Expression by Phenothiazine and Trifluoperazine Suppress Colon Cancer Growth and Migration

Autor: Fiona Thomas, Suhaini Sudi, Falah Abas Muhamad Salih, Praneetha Palasuberniam, Latifah Suali, Mohd Hijaz Mohd Sani, Caroline Sunggip

Publikováno v: Asian Pacific journal of cancer prevention : APJCP. 23(8)

The aim of this study was to investigate the effects of CaM antagonist, PTZ, and TFP on cell proliferation and migration of colon cancer cells and its impact on POPDC protein expression.The 50% inhibitory concentration (IC50) of PTZ and TFP in SW1116

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6341b118b441f6e0484fb1fc3d1cbaaa
https://pubmed.ncbi.nlm.nih.gov/36037145

Different Domains of Dengue Research in Malaysia: A Systematic Review and Meta-Analysis of Questionnaire-Based Studies

Autor: Caroline Sunggip, Rhanye Mac Guad, Yin Nwe Aung, Wah Yun Low, André Barretto Bruno Wilke, Constance Liew Sat Lin, Vetriselvan Subramaniyan, Shamala Devi Sekaran, Maw Shin Sim, Nornazirah Azizan, Mohammad Saffree Jeffree, Yuan Seng Wu, Rogie Royce Carandang, Chandrika Murugaiah, Hamed Taherdoost

Publikováno v: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 18, Iss 4474, p 4474 (2021)

This review provided a systematic overview of the questionnaire-related dengue studies conducted in Malaysia and evaluated their reliability and validity used in the questionnaires. An extensive literature search was conducted using various electroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5327768dae1c93e974c36081ad1e07c
https://pubmed.ncbi.nlm.nih.gov/33922427

Modulation of P2Y

Autor: Kakeru, Shimoda, Akiyuki, Nishimura, Caroline, Sunggip, Tomoya, Ito, Kazuhiro, Nishiyama, Yuri, Kato, Tomohiro, Tanaka, Hidetoshi, Tozaki-Saitoh, Makoto, Tsuda, Motohiro, Nishida

Publikováno v: Scientific Reports

Cardiac tissue remodeling caused by hemodynamic overload is a major clinical outcome of heart failure. Uridine-responsive purinergic P2Y6 receptor (P2Y6R) contributes to the progression of cardiovascular remodeling in rodents, but it is not known whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d9bb874da00548c4f1797931d13799f
https://pubmed.ncbi.nlm.nih.gov/32811872