Výsledky vyhledávání - "Caroline S. Simms"

Synthesis of a transition state analogue for the hydrolysis of cocaine: Assistance to phosphonylation of a 3β-hydroxytropane by a neighbouring amide group

Autor: Caroline S. Simms, Elizabeth L. Ostler, Eleni Hagi-Pavli, Keith Brocklehurst, Gerard Gallacher

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 9:1881-1884

A simple synthesis of phenylphosphonate monoester analogues of the transition state for hydrolysis of the benzoyl ester group in cocaine is provided by the reaction of 2beta-amido-3beta-tropanols with phenylphosphonyl dichloride. Steric hindrance to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8059f2f9a123c566037c0cc4dbed63f1
https://doi.org/10.1016/s0960-894x(99)00293-0

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Characterization of the hydrolytic activity of a polyclonal catalytic antibody preparation by pH-dependence and chemical modification studies: evidence for the involvement of Tyr and Arg side chains as hydrogen-bond donors

Autor: Roberta Vigna, Eleni Hagi-Pavli, Chandra S. Verma, Aaron B. Watts, Gerard Gallacher, Keith Brocklehurst, Caroline S. Simms, Marina Resmini, Nicola J. Barber

Publikováno v: Biochemical Journal. 326:279-287

The hydrolyses of 4-nitrophenyl 4′-(3-aza-2-oxoheptyl)phenyl carbonate and of a new, more soluble, substrate, 4-nitrophenyl 4′-(3-aza-7-hydroxy-2-oxoheptyl)phenyl carbonate, each catalysed by a polyclonal antibody preparation elicited in a sheep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad22df5b65217c30c06bcebfa86fb65c
https://doi.org/10.1042/bj3260279

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ChemInform Abstract: Synthesis of a Transition State Analogue for the Hydrolysis of Cocaine: Assistance to Phosphonylation of a 3β-Hydroxytropane by a Neighboring Amide Group

Autor: Caroline S. Simms, Keith Brocklehurst, Eleni P. Hagi‐Pavli, Gerard Gallacher, Elizabeth L. Ostler

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5da9c6ce96d5d4a6a32ac0922b8720ce
https://doi.org/10.1002/chin.199943209

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Are polyclonal catalytic antibodies heterogeneous?

Autor: Keith Brocklehurst, Suneal K. Sreedharan, Marina Resmini, Steven Carter, Gerard Gallacher, Caroline S. Simms

Publikováno v: Biochemical Society Transactions. 25:86S-86S

Following the first demonstration of antibody-mediated catalysis in 1986 [ 1,2] most investigations have been concerned with monoclonal antibodies [3-51. Another aspect of the field is concerned with polyclonal catalytic antibodies. The finding (revi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45146c449402ecf349fd21842ba49cc
https://doi.org/10.1042/bst025086s

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