Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Caroline Rynn"'
Autor:
Arnold Donkor Forkuo, Charles Ansah, David Pearson, Werner Gertsch, Amanda Cirello, Adam Amaral, Jaimie Spear, Colin W. Wright, Caroline Rynn
Publikováno v:
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and i
Externí odkaz:
https://doaj.org/article/ca794fc0828249698b636214527178ef
Autor:
Sébastien Jeay, Swann Gaulis, Stéphane Ferretti, Hans Bitter, Moriko Ito, Thérèse Valat, Masato Murakami, Stephan Ruetz, Daniel A Guthy, Caroline Rynn, Michael R Jensen, Marion Wiesmann, Joerg Kallen, Pascal Furet, François Gessier, Philipp Holzer, Keiichi Masuya, Jens Würthner, Ensar Halilovic, Francesco Hofmann, William R Sellers, Diana Graus Porta
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/29da49791cad4fb8895cef0bf7f76fea
Autor:
Sébastien Jeay, Swann Gaulis, Stéphane Ferretti, Hans Bitter, Moriko Ito, Thérèse Valat, Masato Murakami, Stephan Ruetz, Daniel A Guthy, Caroline Rynn, Michael R Jensen, Marion Wiesmann, Joerg Kallen, Pascal Furet, François Gessier, Philipp Holzer, Keiichi Masuya, Jens Würthner, Ensar Halilovic, Francesco Hofmann, William R Sellers, Diana Graus Porta
Publikováno v:
eLife, Vol 4 (2015)
Biomarkers for patient selection are essential for the successful and rapid development of emerging targeted anti-cancer therapeutics. In this study, we report the discovery of a novel patient selection strategy for the p53–HDM2 inhibitor NVP-CGM09
Externí odkaz:
https://doaj.org/article/c47da66860c643148939459e36ed4a7e
Publikováno v:
Inducing Targeted Protein Degradation. :313-336
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69068f34af5e23613f10407689898f88
https://doi.org/10.1002/9783527836208.ch12
https://doi.org/10.1002/9783527836208.ch12
Autor:
Ulrike Obst-Sander, Antonio Ricci, Bernd Kuhn, Thomas Friess, Philipp Koldewey, Andreas Kuglstatter, David Hewings, Annick Goergler, Sandra Steiner, Daniel Rueher, Marie-Paule Imhoff, Noemi Raschetti, Hans-Peter Marty, Aline Dietzig, Caroline Rynn, Andreas Ehler, Dominique Burger, Martin Kornacker, Jeannine Petrig Schaffland, Frank Herting, William Pao, James R. Bischoff, Bruno Martoglio, Yvonne Alice Nagel, Georg Jaeschke
Publikováno v:
Journal of Medicinal Chemistry. 65:13052-13073
Addressing resistance to third-generation EGFR TKIs such as osimertinib via the EGFR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74efbfc9bf49e264df4c98794327c038
https://doi.org/10.1021/acs.jmedchem.2c00893
https://doi.org/10.1021/acs.jmedchem.2c00893
Autor:
Piergiorgio Pettazzoni, James R. Bischoff, Bruno Martoglio, Gabriel Schnetzler, Mitchell P. Levesque, Reinhard Dummer, David S. Hewings, Alessandro Brigo, Marina Bacac, Alison Ribeiro, Dominik Rüttinger, Daniela Krummenacher, Daniel Hunziker, Nicolas Frances, Frank Herting, Jan Eckmann, Jasmin Emmenegger, Cornelia Handl, Martin Kornacker, Jeannine Petrig-Schaffland, Thomas Friess, Caroline Rynn, Jürgen Wichmann
Purpose:Disease progression in BRAF V600E/K positive melanomas to approved BRAF/MEK inhibitor therapies is associated with the development of resistance mediated by RAF dimer inducing mechanisms. Moreover, progressing disease after BRAFi/MEKi frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2843c44991336c397978b9069d4f8bb4
https://doi.org/10.1158/1078-0432.c.6531080.v1
https://doi.org/10.1158/1078-0432.c.6531080.v1
Autor:
Piergiorgio Pettazzoni, James R. Bischoff, Bruno Martoglio, Gabriel Schnetzler, Mitchell P. Levesque, Reinhard Dummer, David S. Hewings, Alessandro Brigo, Marina Bacac, Alison Ribeiro, Dominik Rüttinger, Daniela Krummenacher, Daniel Hunziker, Nicolas Frances, Frank Herting, Jan Eckmann, Jasmin Emmenegger, Cornelia Handl, Martin Kornacker, Jeannine Petrig-Schaffland, Thomas Friess, Caroline Rynn, Jürgen Wichmann
Supplementary Data from Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13025a5f335ff95cafd17d5c42454b84
https://doi.org/10.1158/1078-0432.22483133
https://doi.org/10.1158/1078-0432.22483133
Autor:
Piergiorgio Pettazzoni, James R. Bischoff, Bruno Martoglio, Gabriel Schnetzler, Mitchell P. Levesque, Reinhard Dummer, David S. Hewings, Alessandro Brigo, Marina Bacac, Alison Ribeiro, Dominik Rüttinger, Daniela Krummenacher, Daniel Hunziker, Nicolas Frances, Frank Herting, Jan Eckmann, Jasmin Emmenegger, Cornelia Handl, Martin Kornacker, Jeannine Petrig-Schaffland, Thomas Friess, Caroline Rynn, Jürgen Wichmann
Supplementary Table from Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cebd716c1003033988969a2d1ed6815
https://doi.org/10.1158/1078-0432.22483118
https://doi.org/10.1158/1078-0432.22483118
Autor:
Katja Heinig, Filippo Sladojevich, Jeannine Petrig Schaffland, Georg Jaeschke, Alfred Ross, Philipp Koldewey, Saša M. Miladinović, Jin Wang, Caroline Rynn
Publikováno v:
Pharmaceutical Research. 39:653-667
Exploration of the chemical, analytical and pharmacokinetic properties of the API, RO7304898, an allosteric EGFR inhibitor, intended to be developed as a mixture of two rapidly interconverting diastereoisomers with composition ratio of approximately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a73e622a7a6ab994ee6fe51bf457a35
https://doi.org/10.1007/s11095-022-03234-w
https://doi.org/10.1007/s11095-022-03234-w
Autor:
Laurie P Volak, Heide Marika Duevel, Sara Humphreys, David Nettleton, Colin Phipps, Andy Pike, Caroline Rynn, Paul Scott-Stevens, Donglu Zhang, Michael Zientek
Publikováno v:
Drug Metabolism and Disposition. :DMD-AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15157c684e786e7379b9c06455c45b7c
https://doi.org/10.1124/dmd.122.001154
https://doi.org/10.1124/dmd.122.001154