Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Caroline Rivard Costa"'
Autor:
Haixia Wang, Marat Alimzhanov, Paul Lyne, Jason Grant Kettle, Jie Shi, Aarti Kawatkar, Linette Ruston, Geraldine Bebernitz, Richard Woessner, Dennis Huszar, Melissa Vasbinder, Michael Zinda, Weijia Zheng, Andrew D. Ferguson, Thomas Gero, Scott Throner, Patricia Schroeder, Kirsten Bell, Minwei Ye, Neil P. Grimster, Allan Wu, Caroline Rivard Costa, Qibin Su, Dorin Toader, Claudio Chuaqui, Jon Read, Andreas Harsch, Tracy L. Deegan, Erica Anderson
Publikováno v:
Journal of Medicinal Chemistry. 61:5235-5244
Janus kinases (JAKs) have been demonstrated to be critical in cytokine signaling and have thus been implicated in both cancer and inflammatory diseases. The JAK family consists of four highly homologous members: JAK1-3 and TYK2. The development of sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8f93ed398355884d7771aa4e28e3aa
https://doi.org/10.1021/acs.jmedchem.8b00076
https://doi.org/10.1021/acs.jmedchem.8b00076
Autor:
Tina Howard, Jie Shi, Kirsten Bell, Jon Read, Dennis Huszar, Marat Alimzhanov, Claudio Chuaqui, Lynsie Almeida, Geraldine Bebernitz, Michael Zinda, Shan Huang, Qibin Su, Stephanos Ioannidis, Mei Su, Michael Howard Block, Minwei Ye, Caroline Rivard Costa
Publikováno v:
Journal of Medicinal Chemistry. 57:144-158
Structure based design, synthesis, and biological evaluation of a novel series of 1-methyl-1H-imidazole, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described. Using the C-ring fragment from our first clinical candidate AZD1480 (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab13e0e0cd5b5d00f867f1419e01319
https://doi.org/10.1021/jm401546n
https://doi.org/10.1021/jm401546n
Autor:
Larry Bao, Jamal Carlos Saeh, Emma L. Cooke, Christopher R. Denz, Claudio Chuaqui, Bo Peng, James E. Dowling, Qing Ye, Caroline Rivard-Costa, Michael Howard Block, Marat Alimzhanov, Paul Lyne, Timothy Pontz, Shan Huang, Kumar Thakur, Alexander Hird, Nicholas A. Larsen, Tao Zhang
Publikováno v:
ACS Medicinal Chemistry Letters. 4:800-805
In this letter, we describe the design, synthesis, and structure-activity relationship of 5-anilinopyrazolo[1,5-a]pyrimidine inhibitors of CK2 kinase. Property-based optimization of early leads using the 7-oxetan-3-yl amino group led to a series of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91328c92e5f5b40f52e7ed4fcf60cf33
https://doi.org/10.1021/ml400197u
https://doi.org/10.1021/ml400197u