Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Caroline Rivard"'
Autor:
Haixia Wang, Marat Alimzhanov, Paul Lyne, Jason Grant Kettle, Jie Shi, Aarti Kawatkar, Linette Ruston, Geraldine Bebernitz, Richard Woessner, Dennis Huszar, Melissa Vasbinder, Michael Zinda, Weijia Zheng, Andrew D. Ferguson, Thomas Gero, Scott Throner, Patricia Schroeder, Kirsten Bell, Minwei Ye, Neil P. Grimster, Allan Wu, Caroline Rivard Costa, Qibin Su, Dorin Toader, Claudio Chuaqui, Jon Read, Andreas Harsch, Tracy L. Deegan, Erica Anderson
Publikováno v:
Journal of Medicinal Chemistry. 61:5235-5244
Janus kinases (JAKs) have been demonstrated to be critical in cytokine signaling and have thus been implicated in both cancer and inflammatory diseases. The JAK family consists of four highly homologous members: JAK1-3 and TYK2. The development of sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8f93ed398355884d7771aa4e28e3aa
https://doi.org/10.1021/acs.jmedchem.8b00076
https://doi.org/10.1021/acs.jmedchem.8b00076
Akademický článek
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Autor:
Tina Howard, Jie Shi, Kirsten Bell, Jon Read, Dennis Huszar, Marat Alimzhanov, Claudio Chuaqui, Lynsie Almeida, Geraldine Bebernitz, Michael Zinda, Shan Huang, Qibin Su, Stephanos Ioannidis, Mei Su, Michael Howard Block, Minwei Ye, Caroline Rivard Costa
Publikováno v:
Journal of Medicinal Chemistry. 57:144-158
Structure based design, synthesis, and biological evaluation of a novel series of 1-methyl-1H-imidazole, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described. Using the C-ring fragment from our first clinical candidate AZD1480 (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab13e0e0cd5b5d00f867f1419e01319
https://doi.org/10.1021/jm401546n
https://doi.org/10.1021/jm401546n
Autor:
Larry Bao, Jamal Carlos Saeh, Emma L. Cooke, Christopher R. Denz, Claudio Chuaqui, Bo Peng, James E. Dowling, Qing Ye, Caroline Rivard-Costa, Michael Howard Block, Marat Alimzhanov, Paul Lyne, Timothy Pontz, Shan Huang, Kumar Thakur, Alexander Hird, Nicholas A. Larsen, Tao Zhang
Publikováno v:
ACS Medicinal Chemistry Letters. 4:800-805
In this letter, we describe the design, synthesis, and structure-activity relationship of 5-anilinopyrazolo[1,5-a]pyrimidine inhibitors of CK2 kinase. Property-based optimization of early leads using the 7-oxetan-3-yl amino group led to a series of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91328c92e5f5b40f52e7ed4fcf60cf33
https://doi.org/10.1021/ml400197u
https://doi.org/10.1021/ml400197u
Autor:
Jiaquan Wu, Jon Read, Shan Huang, Geraldine Bebernitz, Michael Zinda, Syeed Hussain, Marat Alimzhanov, Kirsten Bell, Nancy DeGrace, Michelle Lamb, Guan Huiping, Caroline Rivard, Stephanos Ioannidis, Minwei Ye, Bo Peng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3105-3110
The discovery of the activating mutation V617F in the JH2 domain of Jak2 and the modulation of oncogenic Stat3 by Jak2 inhibitors have spurred a great interest in the inhibition of the Jak2/Stat pathway in oncology. In this Letter, we communicate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6a2791a8a3f7af3ef48c74521912bf
https://doi.org/10.1016/j.bmcl.2013.02.111
https://doi.org/10.1016/j.bmcl.2013.02.111
Publikováno v:
Org. Biomol. Chem.. 4:3790-3801
gamma-Glutamyl transpeptidase (GGT, EC 2.3.2.2) is a highly glycosylated heterodimeric enzyme linked to the external cellular membrane that catalyzes the hydrolysis of glutathione as well as the transfer of its gamma-glutamyl group to amino acids and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97caee52931e5416d9b3341dc1f4b5c
https://doi.org/10.1039/b606914b
https://doi.org/10.1039/b606914b
Publikováno v:
Journal of Physical Organic Chemistry. 17:529-536
The enzyme γ-glutamyl transpeptidase (GGT) is implicated in cellular detoxification, the biosynthesis of leukotrienes and control of the physiological concentration of glutathione. It also plays important roles in Parkinson's disease, diabetes, apop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::912a2c5d79be76635beb7281f80999be
https://doi.org/10.1002/poc.777
https://doi.org/10.1002/poc.777
Autor:
Hai-Jun Zhang, Tina Howard, Isabelle Green, Marat Alimzhanov, Minwei Ye, Michael Howard Block, Hannah Pollard, Ethan Hoffmann, Lynsie Almeida, Mei Su, Stephanos Ioannidis, Michael Zinda, Kirsten Bell, Jon Read, Geraldine Bebernitz, Davies Audrey, Dennis Huszar, Michelle Lamb, Tao Wang, Caroline Rivard, Bo Peng
Publikováno v:
Journal of medicinal chemistry. 54(1)
The myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are a heterogeneous but related group of hematological malignancies characterized by clonal expansion of one or more myeloid lineages. The di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f5f08188f39c17cf7c191bf5891a78
https://pubmed.ncbi.nlm.nih.gov/21138246
https://pubmed.ncbi.nlm.nih.gov/21138246
Autor:
Annie Ménard, Christian Lherbet, Caroline Rivard, Jeffrey W. Keillor, Yoann Roupioz, Roselyne Castonguay
Publikováno v:
Biochemistry. 40(42)
The gamma-glutamyl transpeptidase (GGT) purified from rat kidney reacts with a series of eight parasubstituted L-glutamyl gamma-anilides, in the presence of Gly-Gly, catalyzing the formation of gamma-Glu-Gly-Gly (pH 8.0, 37 degrees C). The transpepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0628de2944ba6adba271d9ae43875e15
https://pubmed.ncbi.nlm.nih.gov/11601992
https://pubmed.ncbi.nlm.nih.gov/11601992
Akademický článek
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