Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Caroline R. Archer"'
Autor:
Emma L. Robinson, Faye M. Drawnel, Saher Mehdi, Caroline R. Archer, Wei Liu, Hanneke Okkenhaug, Kanar Alkass, Jan Magnus Aronsen, Chandan K. Nagaraju, Ivar Sjaastad, Karin R. Sipido, Olaf Bergmann, J. Simon C. Arthur, Xin Wang, H. Llewelyn Roderick
Publikováno v:
Cells, Vol 11, Iss 4, p 604 (2022)
Heart failure is a leading cause of death that develops subsequent to deleterious hypertrophic cardiac remodelling. MAPK pathways play a key role in coordinating the induction of gene expression during hypertrophy. Induction of the immediate early ge
Externí odkaz:
https://doaj.org/article/a244854a2c694e5daf4f6e2ef48d4de1
Autor:
Ivar Sjaastad, Caroline R. Archer, J. Simon C. Arthur, Jan Magnus Aronsen, H. Llewelyn Roderick, Emma L. Robinson, Hanneke Okkenhaug, Olaf Bergmann, Xin Wang, Kanar Alkass, Saher Mehdi, Faye M. Drawnel, Chandan K. Nagaraju, Wei Liu, Karin R. Sipido
Heart failure is a leading cause of death that develops subsequent to deleterious hypertrophic cardiac remodelling. MAPK pathways play a key role in coordinating the induction of gene expression during hypertrophy. Induction of the immediate early ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6543680c368561d375e2017be3cbe1a8
https://doi.org/10.1101/2020.07.28.224832
https://doi.org/10.1101/2020.07.28.224832
Autor:
Jayati Basak, Jennifer Barnes, Rebecca Sargeant, Amy Pointon, James Pilling, Caroline R. Archer
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Scientific Reports
Pharmaceutical agents despite their efficacy to treat disease can cause additional unwanted cardiovascular side effects. Cardiotoxicity is characterized by changes in either the function and/or structure of the myocardium. Over recent years, function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1ef11187943ee12ff0f9aa4d1293d4
http://link.springer.com/article/10.1038/s41598-018-28393-y
http://link.springer.com/article/10.1038/s41598-018-28393-y
Publikováno v:
Toxicological Sciences. 155:444-457
Cardiotoxicity is a common cause of attrition in preclinical and clinical drug development. Current in vitro approaches have two main limitations, they either are limited to low throughput methods not amendable to drug discovery or lack the physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4879605852db237fb81b6c3f36faa1b
https://doi.org/10.1093/toxsci/kfw227
https://doi.org/10.1093/toxsci/kfw227
Publikováno v:
Cellular Signalling
Cellular Signalling, 36, 240-254. Elsevier Science
Cellular Signalling, 36, 240-254. Elsevier Science
G-protein coupled receptor (GPCR) mediated activation of the MAPK signalling cascade is a key pathway in the induction of hypertrophic remodelling of the heart – a response to pathological cues including hypertension and myocardial infarction. Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19cb407f9f74272b30ad3d70ef8936da
https://lirias.kuleuven.be/handle/123456789/584124
https://lirias.kuleuven.be/handle/123456789/584124
Publikováno v:
British Journal of Pharmacology. 168:296-317
Endothelin-1 (ET-1) is a critical autocrine and paracrine regulator of cardiac physiology and pathology. Produced locally within the myocardium in response to diverse mechanical and neurohormonal stimuli, ET-1 acutely modulates cardiac contractility.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fd09ce754a97750ab29769cf756a1a0
https://doi.org/10.1111/j.1476-5381.2012.02195.x
https://doi.org/10.1111/j.1476-5381.2012.02195.x
Autor:
Joanne L. Yarker, Steffen Lawo, Jonathan D. Moore, Caroline R. Archer, Benedict C. S. Cross, Alessandro Riccombeni, Jessica Hunt, Annette S. Little, Nicola J. McCarthy
Publikováno v:
Sci Rep
Scientific Reports
Scientific Reports
Components of the type II CRISPR–Cas complex in bacteria have been used successfully in eukaryotic cells to facilitate rapid and accurate cell line engineering, animal model generation and functional genomic screens. Such developments are providing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bb97cc5e0c2130bbdcb12540ffc7d9
https://hdl.handle.net/21.11116/0000-000B-7158-3
https://hdl.handle.net/21.11116/0000-000B-7158-3
Autor:
Caroline R. Archer, Amy Pointon
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:235-236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fc33155914849af06730a2bca0c91b0
https://doi.org/10.1016/j.vascn.2017.09.221
https://doi.org/10.1016/j.vascn.2017.09.221
Publikováno v:
Toxicology Letters. 295:S109
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aae60b800f3b808f5e0952bd6d666ba
https://doi.org/10.1016/j.toxlet.2018.06.632
https://doi.org/10.1016/j.toxlet.2018.06.632
Autor:
Yinhai Wang, Jayati Basak, Jen Barnes, James Pilling, Caroline R. Archer, Rebecca Sargeant, Amy Pointon
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bab561420895d61927769200edc5d68e
https://doi.org/10.1016/j.vascn.2018.01.541
https://doi.org/10.1016/j.vascn.2018.01.541