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pro vyhledávání: '"Caroline Poock"'
Autor:
Markus Kalesse, Caroline Poock
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry-A European Journal 27 (2020), Nr. 5
Chemistry (Weinheim an der Bergstrasse, Germany)
Germany
Chemistry-A European Journal 27 (2020), Nr. 5
Chemistry (Weinheim an der Bergstrasse, Germany)
Germany
The first total synthesis of halioxepine is accomplished using a 1,4‐addition for constructing the quaternary center at C10 and a halo etherification for the generation of the tertiary ether at C7. The correct structure of halioxepine was determine
Autor:
Caroline Poock, Markus Kalesse
Publikováno v:
Organic Letters. 19:4536-4539
The total synthesis of nannocystin Ax in an overall yield of 11% with 14 steps as the longest linear sequence is reported. Nannocystin Ax is a cytotoxic 21-membered depsipeptide and was isolated from the myxobacterial genus Nannocystis sp. The synthe
Autor:
Marc Heinrich, Shiyan Xu, Barry M. Trost, Craig Stivala, Jullien Rey, Caroline Poock, Christoph Hohn, Wen-Ju Bai
Publikováno v:
Journal of the American Chemical Society. 140(49)
The synthesis of des-epoxy-amphidinolide N was achieved in 22 longest linear and 33 total steps. Three generations of synthetic endeavors are reported herein. During the first generation, our key stitching strategy that highlighted an intramolecular
Autor:
Rainer Kalkofen, Barry M. Trost, Daniel R. Fandrick, Caroline Poock, Audris Huang, Kami L. Hull, Craig Stivala
Publikováno v:
Journal of the American Chemical Society. 138(36)
The lasonolides are novel polyketides that have displayed remarkable biological activity in vitro against a variety of cancer cell lines. Herein we describe our first-generation approach to the formal synthesis of lasonolide A. The key findings from