Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Caroline Manicam"'
Autor:
Till Grandjean, Natarajan Perumal, Caroline Manicam, Björn Matthey, Tao Wu, Daniel G. E. Thiem, Stefan Stein, Dirk Henrich, Peer W. Kämmerer, Bilal Al-Nawas, Ulrike Ritz, Sebastian Blatt
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction:Autologous platelet concentrate (APC) are pro-angiogenic and can promote wound healing and tissue repair, also in combination with other biomaterials. However, challenging defect situations remain demanding. 3D bioprinting of an APC base
Externí odkaz:
https://doaj.org/article/f94a2e03f41a4c73ad8bb71eefec4252
Publikováno v:
Cells, Vol 13, Iss 9, p 775 (2024)
Glaucoma is a heterogeneous group of optic neuropathies characterized by a progressive degeneration of the retinal ganglion cells (RGCs), leading to irreversible vision loss. Nowadays, the traditional therapeutic approach to glaucoma consists of lowe
Externí odkaz:
https://doaj.org/article/c08e0828d37949c29e5fec71efd247c6
Autor:
Thu Nguyen Minh Pham, Natarajan Perumal, Caroline Manicam, Marion Basoglu, Stefan Eimer, Dominik C. Fuhrmann, Claus U. Pietrzik, Albrecht M. Clement, Hagen Körschgen, Jana Schepers, Christian Behl
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102943- (2023)
Accumulation of misfolded proteins or perturbation of calcium homeostasis leads to endoplasmic reticulum (ER) stress and is linked to the pathogenesis of neurodegenerative diseases. Hence, understanding the ability of neuronal cells to cope with chro
Externí odkaz:
https://doaj.org/article/2ab18361f6574f718608e4d28f325c01
Autor:
Francesco Buonfiglio, Ning Xia, Can Yüksel, Caroline Manicam, Subao Jiang, Jenia Kouchek Zadeh, Aytan Musayeva, Eva Elksne, Norbert Pfeiffer, Andreas Patzak, Huige Li, Adrian Gericke
Publikováno v:
Diseases, Vol 11, Iss 4, p 124 (2023)
Atherogenic lipoproteins may impair vascular reactivity, leading to tissue damage in various organs, including the eye. This study aimed to investigate whether ophthalmic artery reactivity is affected in mice lacking the apolipoprotein E gene (ApoE
Externí odkaz:
https://doaj.org/article/1cfb0c37382d4bf09e614c9a206c61f0
Autor:
Jiong Hu, Marco Sisignano, Roman Brecht, Natarajan Perumal, Carlo Angioni, Iris-Sofia Bibli, Beate Fisslthaler, Hartmut Kleinert, Norbert Pfeiffer, Ingrid Fleming, Caroline Manicam
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Cytochrome P450 (CYP) signalling pathway has been shown to play a vital role in the vasoreactivity of wild type mouse ophthalmic artery. In this study, we determined the expression, vascular responses and potential mechanisms of the CYP-deri
Externí odkaz:
https://doaj.org/article/7c86336bfbe8447db07c79cc9df5eb60
Autor:
Panagiotis Chronopoulos, Caroline Manicam, Jenia Kouchek Zadeh, Panagiotis Laspas, Johanna Charlotte Unkrig, Marie Luise Göbel, Aytan Musayeva, Norbert Pfeiffer, Matthias Oelze, Andreas Daiber, Huige Li, Ning Xia, Adrian Gericke
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 853 (2023)
Ischemia-reperfusion (I/R) events are involved in the development of various ocular pathologies, e.g., retinal artery or vein occlusion. We tested the hypothesis that resveratrol is protective against I/R injury in the murine retina. Intraocular pres
Externí odkaz:
https://doaj.org/article/12abbd60732d43ba83a355cc31a186d3
Autor:
David P. Herzog, Natarajan Perumal, Caroline Manicam, Giulia Treccani, Jens Nadig, Milena Rossmanith, Jan Engelmann, Tanja Jene, Annika Hasch, Michael A. van der Kooij, Klaus Lieb, Nils C. Gassen, Franz H. Grus, Marianne B. Müller
Publikováno v:
Neurobiology of Stress, Vol 15, Iss , Pp 100404- (2021)
Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown.
Externí odkaz:
https://doaj.org/article/d8aba74592bc42718b2bc6bf8e42ffef
Publikováno v:
Cells, Vol 11, Iss 21, p 3494 (2022)
Cytochrome P450 (CYP) gene mutations are a common predisposition associated with glaucoma. Although the molecular mechanisms are largely unknown, omega-3 polyunsaturated fatty acids (ω-3 PUFA) and their CYP-derived bioactive mediators play crucial r
Externí odkaz:
https://doaj.org/article/f2b636b7794e422b888e5b8001c9d995
Autor:
Natarajan Perumal, Lars Straßburger, David P. Herzog, Marianne B. Müller, Norbert Pfeiffer, Franz H. Grus, Caroline Manicam
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101597- (2020)
Ocular vascular dysfunction is a major contributing factor to the pathogenesis of glaucoma. In recent years, there has been a renewed interest in the role of angiotensin II (Ang II) in mediating the disease progression. Despite its (patho)physiologic
Externí odkaz:
https://doaj.org/article/08ed5b623f464738a155452d5bc5709a
Autor:
Aytan Musayeva, Johanna C. Unkrig, Mayagozel B. Zhutdieva, Caroline Manicam, Yue Ruan, Panagiotis Laspas, Panagiotis Chronopoulos, Marie L. Göbel, Norbert Pfeiffer, Christoph Brochhausen, Andreas Daiber, Matthias Oelze, Huige Li, Ning Xia, Adrian Gericke
Publikováno v:
Cells, Vol 10, Iss 9, p 2440 (2021)
Ischemia/reperfusion (I/R) events are involved in the pathophysiology of numerous ocular diseases. The purpose of this study was to test the hypothesis that betulinic acid protects from I/R injury in the mouse retina. Ocular ischemia was induced in m
Externí odkaz:
https://doaj.org/article/60328903705e41018e948969cb3edace