Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Caroline MacLean"'
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 405 (2020)
The Caco-2 model is a well-accepted in vitro model for the estimation of fraction absorbed in human intestine. Due to the lack of cytochrome P450 3A4 (CYP3A4) activities, Caco-2 model is not suitable for the investigation of intestinal first-pass met
Externí odkaz:
https://doaj.org/article/b823dcf6935c41d2a76c09651b0d8d61
Autor:
Kohei Ito, Marina Naoi, Kotaro Nishiyama, Takashi Kudo, Yasuhiro Tsuda, Caroline MacLean, Naoki Ishiguro
Publikováno v:
Drug Metabolism and Pharmacokinetics. 49:100487
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8096f8d42137b825b453a49658d4401
https://doi.org/10.1016/j.dmpk.2022.100487
https://doi.org/10.1016/j.dmpk.2022.100487
Autor:
Lucio Reyes, David Godfrey, Caroline MacLean, Francisco Gonzalez, Lorena Madrigal, Li-June Ming
Publikováno v:
American journal of human biology : the official journal of the Human Biology CouncilREFERENCES. 33(6)
Objectives To explore evolutionary hypotheses for the high frequencies of a substitution in the methylenetetrahydrofolate reductase (MTHFR) gene, in Mexican and Central American Indigenous populations. Materials and methods We obtained allele frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d323b744b26988dbb65546942ab6a23e
https://pubmed.ncbi.nlm.nih.gov/33458918
https://pubmed.ncbi.nlm.nih.gov/33458918
Autor:
Caroline Maclean
A spellbinding portrait of the Hampstead Modernists, threading together the lives, loves, rivalries and ambitions of a group of artists at the heart of an international avant-garde.Hampstead in the 1930s. In this peaceful, verdant London suburb, Barb
Publikováno v:
Journal of pharmaceutical sciences. 106(12)
In vitro investigations on enzyme induction are indispensable for assessing drug–drug interactions of drug candidates. Regulatory bodies require measurement of changes of mRNA in cultured human hepatocytes. However, such data provide only indirect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a5499c7d087244eaeac3d185911498
https://pubmed.ncbi.nlm.nih.gov/28778426
https://pubmed.ncbi.nlm.nih.gov/28778426
Autor:
Melanie Ott, Evelyn Hollnack-Pusch, Anne Mahringer, Valeska Reichel, Caroline MacLean, Gert Fricker, Isolde Reimold
Publikováno v:
Journal of Nanoneuroscience. 2:5-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dbf9596cce9e035a2989113a27580b4
https://doi.org/10.1166/jns.2012.1012
https://doi.org/10.1166/jns.2012.1012
Autor:
Caroline Maclean
Publikováno v:
Literature & History. 21:44-60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ab487333f8074395c3cb28f794789d9
https://doi.org/10.7227/lh.21.1.4
https://doi.org/10.7227/lh.21.1.4
Publikováno v:
European Journal of Pharmaceutical Sciences. 41:670-674
Purpose Expression of Pgp along the GI-tract of rats increases towards distal segments. We assessed the in vivo relevance by determining the absorption of fexofenadine from proximal and distal parts of rat intestine. Since it has been reported that f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad224a098e47a357314346978eb35e2
https://doi.org/10.1016/j.ejps.2010.09.007
https://doi.org/10.1016/j.ejps.2010.09.007
Publikováno v:
Drug Metabolism and Disposition. 36:1249-1254
Intestinal ATP binding cassette (ABC) transporters may affect the bioavailability and effectiveness of orally administered drugs. Available studies on regional expression of intestinal efflux transporters were done with selected intestinal segments o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3764059f34a0f0030abbcc866f7b875
https://doi.org/10.1124/dmd.108.020859
https://doi.org/10.1124/dmd.108.020859