Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Caroline M. Milner"'
Autor:
Anthony J. Day, Douglas P. Dyer, Nikolaos Kouvatsos, Leela C Biant, Jennifer M. Thomson, Caroline M. Milner, Andrew Price, Sanjay Anand, Eckart Bartnik, Jenny L Scott, Matthias Herrmann, Sheona P Drummond, Thomas Leeuw
Publikováno v:
Osteoarthritis and Cartilage.
ObjectivesTo investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA.MethodsKnee articular cartilages from OA pati
Autor:
Joo Youn Oh, Jin Suk Ryu, Hyeon Ji Kim, Nikolaos Kouvatsos, Rebecca J. Dodd, Se Hyun Choi, Yu Jeong Kim, Caroline M. Milner, Anthony J. Day
Publikováno v:
Oh, J Y, Ryu, J S, Kim, H J, Kouvatsos, N, Dodd, R J, Choi, S H, Kim, Y J, Milner, C M & Day, A J 2022, ' The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease ', The ocular surface, vol. 24, pp. 40-50 . https://doi.org/10.1016/j.jtos.2021.12.012
PurposeTo investigate the potential of the Link_TSG6 polypeptide comprising the Link module of human TSG-6 (TNF-stimulated gene/protein-6) as a novel treatment for dry eye disease (DED).MethodsWe analyzed the therapeutic effects of topical applicatio
Autor:
Caroline M. Milner, Anthony J. Day, Holly L. Birchenough, Alexander W.W. Langford-Smith, Jan J. Enghild, Clair Baldock, Cay M. Kielty, David Briggs, Thomas A. Jowitt
Publikováno v:
The Journal of Biological Chemistry
The journal of biological chemistry 295(16), 5278-5291 (2020). doi:10.1074/jbc.RA119.011916
Briggs, D C, Langford-Smith, A W W, Birchenough, H L, Jowitt, T A, Kielty, C M, Enghild, J J, Baldock, C, Milner, C M & Day, A J 2020, ' Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation ', The Journal of Biological Chemistry, vol. 295, no. 16, pp. 5278-5291 . https://doi.org/10.1074/jbc.RA119.011916, https://doi.org/10.1074/jbc.RA119.011916
The journal of biological chemistry 295(16), 5278-5291 (2020). doi:10.1074/jbc.RA119.011916
Briggs, D C, Langford-Smith, A W W, Birchenough, H L, Jowitt, T A, Kielty, C M, Enghild, J J, Baldock, C, Milner, C M & Day, A J 2020, ' Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation ', The Journal of Biological Chemistry, vol. 295, no. 16, pp. 5278-5291 . https://doi.org/10.1074/jbc.RA119.011916, https://doi.org/10.1074/jbc.RA119.011916
Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous "heavy chains" (HC1 and HC2) covalently attached to chondroitin sulfate on the bikuni
Autor:
Anthony J. Day, Alex Langford-Smith, Jan J. Enghild, Thomas A. Jowitt, Caroline M. Milner, Cay M. Kielty, David Briggs, Clair Baldock
Inter-α-inhibitor (IαI) is a proteoglycan essential for mammalian reproduction that also plays a less well-characterised role in inflammation. IαI is composed of 2 homologous ‘heavy chains’ (HC1 and HC2) covalently attached to chondroitin sulp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e907105f7793b42e00b0821d6ab9cb80
https://doi.org/10.1101/695700
https://doi.org/10.1101/695700
Autor:
Panayiota Ploutarchou, Anthony J. Day, Agnes A Archibong-Omon, Suzannah A. Williams, Caroline M. Milner, Belinda K M Lo
Publikováno v:
Lo, B K M, Archibong-Omon, A, Ploutarchou, P, Day, A J, Milner, C M & Williams, S A 2018, ' Oocyte-specific ablation of N-And O-glycans alters cumulus cell signalling and extracellular matrix composition ', Reproduction, Fertility and Development . https://doi.org/10.1071/RD18209
Cumulus–oocyte complex (COC) expansion is essential for ovulation and fertilisation and is linked to oocyte quality. Hyaluronan (HA), the major matrix constituent, is cross-linked via inter-α-inhibitor heavy chains (HCs), pentraxin 3 (PTX3) and tu
Autor:
Anthony J. Day, Caroline M. Milner
Publikováno v:
Day, A & Milner, C 2018, ' TSG-6: a multifunctional protein with anti-inflammatory and tissue-protective properties ', Matrix Biology . https://doi.org/10.1016/j.matbio.2018.01.011
Tumor necrosis factor- (TNF) stimulated gene-6 (TSG-6) is an inflammation-associated secreted protein that has been implicated as having important and diverse tissue protective and anti-inflammatory properties, e.g. mediating many of the immunomodula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c594c2c5743a8b4351c83b2139c6e1e
https://pure.manchester.ac.uk/ws/files/63927942/DayMilner_Matrix_Biology_2018_accepted_version.pdf
https://pure.manchester.ac.uk/ws/files/63927942/DayMilner_Matrix_Biology_2018_accepted_version.pdf
Autor:
Caroline M. Milner, Anthony J. Day, Douglas P. Dyer, Aurelie Hermant, Amanda E. I. Proudfoot, Jennifer M. Thomson, Thomas A. Jowitt, Tracy M. Handel
Publikováno v:
The Journal of Immunology. 192:2177-2185
TNF-stimulated gene/protein-6 (TSG-6) is expressed by many different cell types in response to proinflammatory cytokines and plays an important role in the protection of tissues from the damaging consequences of acute inflammation. Recently, TSG-6 wa
Autor:
David J. Mahoney, Benedict M. Sattelle, Andrew Almond, Paul L. DeAngelis, Caroline M. Milner, Douglas P. Dyer, Anthony J. Day, Charles D. Blundell, David Briggs, Victoria A. Higman, Dixy E. Green
Publikováno v:
The Journal of Biological Chemistry
Background: The polysaccharide hyaluronan is organized through interactions with the protein TSG-6 during inflammation and ovulation. Results: NMR spectroscopy on TSG-6 in the presence of defined sugars provided restraints that allowed modeling of a
Autor:
Caroline M. Milner, Susana M. Casalino-Matsuda, Rosanna Forteza, Erik Fries, Maria E. Monzon, Marilyn S. Rugg, Anthony J. Day
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 36:20-31
TSG-6 (the protein product of TNF-stimulated gene-6), an inflammation-associated protein, forms covalent complexes with heavy chains (HCs) from inter-alpha-inhibitor and pre-alpha-inhibitor and associates noncovalently with their common bikunin chain
Publikováno v:
Biochemical Society Transactions. 34:446-450
TSG-6 is a multifunctional protein that is up-regulated in many pathological and physiological contexts, where it plays important roles in inflammation and tissue remodelling. For example, it is a potent inhibitor of neutrophil migration and can modu