Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Caroline M. Hull"'
Autor:
Caroline M. Hull, John Maher
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/72e7812e55b645ac8726952072e0b314
Autor:
James L. Reading, Valerie D. Roobrouck, Caroline M. Hull, Pablo Daniel Becker, Jelle Beyens, Alice Valentin-Torres, Dominic Boardman, Estefania Nova Lamperti, Samantha Stubblefield, Giovanna Lombardi, Robert Deans, Anthony E. Ting, Timothy Tree
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Recent clinical experience has demonstrated that adoptive regulatory T (Treg) cell therapy is a safe and feasible strategy to suppress immunopathology via induction of host tolerance to allo- and autoantigens. However, clinical trials continue to be
Externí odkaz:
https://doaj.org/article/25e01aabf5a24ceca4ffe9315b68a013
Autor:
Iria Gomez-Tourino, Bart O. Roep, Timothy Tree, Caroline M. Hull, Anna Lorenc, Emily Hanton, Sefina Arif, Mark Peakman, Daisy Melandri, Yogesh Kamra, Irma Pujol-Autonell, Craig A. Beam, Diane K. Wherrett
Publikováno v:
Diabetologia
Aims/hypothesis Antigen-specific therapy aims to modify inflammatory T cell responses in type 1 diabetes and restore immune tolerance. One strategy employs GAD65 conjugated to aluminium hydroxide (GAD-alum) to take advantage of the T helper (Th)2-bia
Autor:
Caroline M. Hull, John Maher
Publikováno v:
Expert Opinion on Biological Therapy. 19:789-799
Following recent breakthrough developments in the application of CAR T-cell treatments for hematologic cancers, the potential of this approach to achieve meaningful impact against solid tumors now warrants careful consideration.Effective deployment o
Autor:
Leena Halim, Antonella Adami, Balázs Győrffy, Lynsey M. Whilding, Benjamin Draper, Ana C. Parente-Pereira, Domenico Cozzetto, Chung-Yang Ricardo Joseph, Helge Roider, Chelsea A. Taylor, Jana Obajdin, Holger Hess-Stumpp, Jinger Xie, Ayesha Iqbal, Richard Beatson, Tomasz Zabinski, Fred Aswad, John Maher, Tom Hardiman, Jelmar Quist, Anette Sommer, Caroline M. Hull, Andrew Tutt, Daniela Achkova, Kim Ngan Luu Hoang, David M. Davies, Rafael Torres Martin de Rosales, Anita Grigoriadis, Francis Man
Publikováno v:
SSRN Electronic Journal.
Despite their role in cancer surveillance, adoptive immunotherapy using γδ T-cells has achieved limited efficacy. To enhance trafficking to bone marrow, circulating γδ T-cells were expanded in serum-free medium containing TGF-β1 and IL-2 (γδ[T
Autor:
James L. Riley, Megan Estorninho, Lauren E. Nickolay, Timothy Tree, Caroline M. Hull, Max W. Richardson, John Maher, Mark Peakman
Publikováno v:
Hull, C M, Nickolay, L E, Estorninho, M, Richardson, M W, Riley, J L, Peakman, M, Maher, J & Tree, T I M 2017, ' Generation of human islet-specific regulatory T cells by TCR gene transfer ', Journal of Autoimmunity, vol. 79, pp. 63-73 . https://doi.org/10.1016/j.jaut.2017.01.001
Based on the success in animal models of type 1 diabetes (T1D), clinical trials of adoptive regulatory T cell (Treg) therapy are underway using ex vivo expanded polyclonal Tregs. However, pre-clinical data also demonstrate that islet-specific Tregs a
Publikováno v:
Diabetologia
Hull, C M, Peakman, M & Tree, T I M 2017, ' Regulatory T cell dysfunction in type 1 diabetes : what's broken and how can we fix it? ', Diabetologia, vol. 60, no. 10, pp. 2661-2807 . https://doi.org/10.1007/s00125-017-4377-1
Hull, C M, Peakman, M & Tree, T I M 2017, ' Regulatory T cell dysfunction in type 1 diabetes : what's broken and how can we fix it? ', Diabetologia, vol. 60, no. 10, pp. 2661-2807 . https://doi.org/10.1007/s00125-017-4377-1
Type 1 diabetes is an autoimmune disease characterised by the destruction of insulin producing beta cells in the pancreas. Whilst it remains unclear what the original triggering factors for this destruction are, observations from the natural history
Autor:
Bart Vaes, Robert J. Deans, Nicholas Lehman, Anthony DiPiero, Anthony E. Ting, Fiona Carty, Shereen Sabbah, Nancy S Wang, Jen M Taggart, Thomas Hayday, Karen English, James L. Reading, Caroline M. Hull, Timothy Tree, Jef Pinxteren
T-cell depletion therapy is used to prevent acute allograft rejection, treat autoimmunity and create space for bone marrow or hematopoietic cell transplantation. The evolved response to T-cell loss is a transient increase in IL-7 that drives compensa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9e68233200722aff14de17787ce563
https://europepmc.org/articles/PMC4817941/
https://europepmc.org/articles/PMC4817941/