Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Caroline M Alexander"'
Autor:
Pippa Kirby, Helen Lai, Sophie Horrocks, Matthew Harrison, Danielle Wilson, Sarah Daniels, Rafael A Calvo, David J Sharp, Caroline M Alexander
Publikováno v:
JMIR Aging, Vol 7, p e48292 (2024)
BackgroundTechnology-related research on people with dementia and their carers often aims to enable people to remain living at home for longer and prevent unnecessary hospital admissions. To develop person-centered, effective, and ethical research, p
Externí odkaz:
https://doaj.org/article/cd8a043824884ce78e9d8ed07e2fd2b9
Autor:
Stephen J Brett, Anthony C Gordon, Christine Norton, Mandy Jones, Caroline M Alexander, Huw R Woodbridge
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Objectives The objective of this study is to explore patient, relative/carer and clinician perceptions of barriers to early physical rehabilitation in intensive care units (ICUs) within an associated group of hospitals in the UK and how they can be o
Externí odkaz:
https://doaj.org/article/7a0fcef1bd7442cab02e45250944e4cb
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279354 (2022)
ObjectivesThe aims of this study were to explore individuals' experiences of contributing to health research and to identify the types of impact that are perceived as important by participants or patient and public advisors. Specifically, research le
Externí odkaz:
https://doaj.org/article/b4e1777fbfa4401daef6173f994c55e3
Publikováno v:
BMJ Open, Vol 11, Iss 10 (2021)
Objectives To explore the perceived impacts of clinical academic activity among the professions outside medicine.Design Qualitative semistructured interviews.Setting and participants There were two groups of interviewees: Research-active nurses, midw
Externí odkaz:
https://doaj.org/article/c7f7d0b81f7f4e519e85e067bf599b80
Autor:
Ildiko Kasza, Yewseok Suh, Damian Wollny, Rod J Clark, Avtar Roopra, Ricki J Colman, Ormond A MacDougald, Timothy A Shedd, David W Nelson, Mei-I Yen, Chi-Liang Eric Yen, Caroline M Alexander
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004514 (2014)
Homeostatic temperature regulation is fundamental to mammalian physiology and is controlled by acute and chronic responses of local, endocrine and nervous regulators. Here, we report that loss of the heparan sulfate proteoglycan, syndecan-1, causes a
Externí odkaz:
https://doaj.org/article/0a76c60c6a304b0f8220dd2a001ef965
Autor:
Bart M G Smits, Jill D Haag, Anna I Rissman, Deepak Sharma, Ann Tran, Alexi A Schoenborn, Rachael C Baird, Dan S Peiffer, David Q Leinweber, Matthew J Muelbl, Amanda L Meilahn, Mark R Eichelberg, Ning Leng, Christina Kendziorski, Manorama C John, Patricia A Powers, Caroline M Alexander, Michael N Gould
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003549 (2013)
Genome-wide association studies have revealed that many low-penetrance breast cancer susceptibility loci are located in non-protein coding genomic regions; however, few have been characterized. In a comparative genetics approach to model such loci in
Externí odkaz:
https://doaj.org/article/c1b2aaae8803497caec92d2d74a0a3cb
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49902 (2012)
Various types of somatic stem cell have been tested for their response to genotoxic exposure, since these cells are likely to be important to regeneration, aging and cancer. In this study, we evaluated the response of mammary stem cells to genotoxic
Externí odkaz:
https://doaj.org/article/c0a9ae4879fd4af98d0b693853aa7f2d
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30979 (2012)
Chemotherapeutic strategies that target basal-like breast tumors are difficult to design without understanding their cellular and molecular basis. Here, we induce tumors in mice by carcinogen administration, creating a phenocopy of tumors with the di
Externí odkaz:
https://doaj.org/article/a098f13157a246b4a889484531b37755
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19310 (2011)
There is a paradox offered up by the cancer stem cell hypothesis. How are the mixed populations that are characteristic of heterogeneous solid tumors maintained at constant proportion, given their high, and different, mitotic indices? In this study,
Externí odkaz:
https://doaj.org/article/66326301de7c453eb7870b20c4fd03bb
Autor:
Nisha M Badders, Shruti Goel, Rod J Clark, Kristine S Klos, Soyoung Kim, Anna Bafico, Charlotta Lindvall, Bart O Williams, Caroline M Alexander
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6594 (2009)
BACKGROUND:Ectopic Wnt signaling induces increased stem/progenitor cell activity in the mouse mammary gland, followed by tumor development. The Wnt signaling receptors, Lrp5/6, are uniquely required for canonical Wnt activity. Previous data has shown
Externí odkaz:
https://doaj.org/article/03ae88e29f3746bf95dec1648eee39c9