Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Caroline L Wilson"'
Autor:
Caroline L Wilson, Jelena Mann, Meagan Walsh, Maria J Perrugoria, Fiona Oakley, Matthew C Wright, Chiara Brignole, Daniela Di Paolo, Patrizia Perri, Mirco Ponzoni, Michael Karin, Derek A Mann
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83391 (2014)
Toll-like Receptor 3 (TLR3) is a pathogen pattern recognition receptor that plays a key role in innate immunity. TLR3 signalling has numerous functions in liver, both in health and disease. Here we report that TLR3 is expressed by quiescent hepatic s
Externí odkaz:
https://doaj.org/article/71f7d585cd604254ace52ba7bc53da0f
Autor:
Sumit Sandhu, Ieng F. Sou, Jill E. Hunter, Lucy Salmon, Caroline L. Wilson, Neil D. Perkins, Neil Hunter, Owen R. Davies, Urszula L. McClurg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Sandhu et al. report that the synaptonemal complex (SC) protein, TEX12, localises to centrosomes independently of the SC during meiosis. They also show that it provokes centrosome amplification in somatic cells, a pathology associated with cancer dev
Externí odkaz:
https://doaj.org/article/d1221d134947415086c9e1e96900d10e
Autor:
Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L. Wilson, Albert Lahat, Christoper P. Day, Alastair Burt, Allyson Palmer, Quentin M. Anstee, Sushma Nagaraja Grellscheid, Jan H J. Hoeijmakers, Sander Barnhoorn, Derek A. Mann, Thomas G. Bird, Wilbert P. Vermeij, James L. Kirkland, João F. Passos, Thomas von Zglinicki, Diana Jurk
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Non-alcoholic fatty liver disease is more common among older individuals. Here, the authors show that senescent cells in the liver promote fat accumulation and steatosis in the liver, and that clearance of senescent cells reduces hepatic steatosis in
Externí odkaz:
https://doaj.org/article/59da7366bd92469288a45b90a4b396f9
Autor:
Amy Collins, Rebecca Scott, Caroline L Wilson, Giuseppe Abbate, Gabrielle Ecclestone, Demi Biddles, Fiona Oakley, Jelena Mann, Derek A Mann, Niall S. Kenneth
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in most types of chronic liver diseases. Fibrosis is associated with the activation of hepatic stellate cells (HSCs) which transdifferentiate into a myofibrobla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3e58ae1c2dda8639cd417d5c143776
https://doi.org/10.1101/2023.01.08.523142
https://doi.org/10.1101/2023.01.08.523142
Autor:
Andrew R. Lloyd, Caroline L. Wilson, Tanya L. Applegate, Richard Harrigan, Rowena A. Bull, Jacob George, Gregory J. Dore, Dao Sen Wang, Enoch Tay, Adrian Ong, Dominic E. Dwyer, Jen Kok, Anita Y. M. Howe, Mark W. Douglas, Amy Phu
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 904-915 (2020)
Hepatology Communications
Hepatology Communications
Direct acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, but drug resistance could undermine proposed global elimination targets. Real-world studies are needed to inform the impact of widespread DAA treatment on antivira
Autor:
Julia Concetti, Caroline L. Wilson
Publikováno v:
Cells, Vol 7, Iss 9, p 133 (2018)
Current evidence strongly suggests that aberrant activation of the NF-κB signalling pathway is associated with carcinogenesis. A number of key cellular processes are governed by the effectors of this pathway, including immune responses and apoptosis
Externí odkaz:
https://doaj.org/article/75040dc8e26a4e9b8650d42f6adc031b
Autor:
Caroline L. Wilson, Olivier Govaere, A. Whitehead, Ahmed Khairallah Mahdi, Jack Leslie, Sirintra Nakjang, Robyn Watson, G.L. Patman, Marco Y W Zaki, Charlotte Cox, Erik Ramon-Gil, João Maurício, John Lunec, Sameh Abou-Beih, Fiona Oakley, Quentin M. Anstee, Ruchi Shukla, Helen L. Reeves, Misti Vanette McCain, Derek A. Mann, Despina Televantou, Dina Tiniakos
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
The prevalence of obesity and non-alcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) is rising, even in the absence of cirrhosis. We aimed to develop a murine model that would facilitate further understanding of NAFLD-HCC
Autor:
Dominik Pfister, Moritz Peiseler, Roland Rad, Monika Julia Wolf, Suchira Gallage, Elena Kotsiliti, Caroline L. Wilson, Tjeerd P. Sijmonsma, Nabil Djouder, Marco Prinz, Daniela C. Kroy, Frank Tacke, Jerry Ware, Adnan Ali, Roser Pinyol, Mike Notohamiprodjo, Tracy O'Connor, Christopher J. Weston, Paul Kubes, Bas G.J. Surewaard, Percy A. Knolle, Achim Weber, Michael D. Milsom, Patrick M. Helbling, Daniel Dauch, Tobias Geisler, Mohsen Malehmir, Carsten Deppermann, Alexander Olkus, Marcel Rall, Hellmut G. Augustin, Lars Zender, Julia Volz, Ana Teijeiro, César Nombela-Arrieta, Malte N. Bongers, Valentina Leone, Mathias Heikenwalder, Matthias S. Matter, Dominic J. Withers, Lozan Sheriff, Alexandros Vegiopoulos, Oliver Krenkel, Oliver Borst, Patricia F. Lalor, Jack Leslie, Anahita Rafiei, Florian Baku, David H. Adams, Adam J. Rose, Bernhard Nieswandt, Thomas Engleitner, Hannah K. Drescher, Dominik Rath, Natasha S Anstee, Marlene Kohlhepp, Marc E. Healy, Marta Szydlowska, Meinrad Gawaz, Ruzhica Bogeska, Kristian Unger, Donato Inverso, David Stegner, Martina Hinterleitner, Derek A. Mann, Josep M. Llovet
Publikováno v:
Nature Medicine
Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show that platelet number, platelet activation and platelet aggregation
Autor:
Leena Habiballa, David Dolan, Anthony B. Lagnado, Madison L. Doolittle, Jodie Birch, Daniel Geh, Helen L. Reeves, Marie-Hélène Ruchaud-Sparagano, Shane A. Evans, Nicola Neretti, Amy L Collins, Sushma Nagaraja Grellscheid, João F. Passos, Derek A. Mann, Thomas von Zglinicki, Sanjay Pandanaboyana, Colin H Wilson, Claudio Akio Masuda, Diana Jurk, Caroline L. Wilson, Tamar Tchkonia, Adam Hruby, Suchira Gallage, Maria Grazia Vizioli, Stella Victorelli, Petra Hirsova, Jack Leslie, Kevin D. Pavelko, Hanna Salmonowicz, Mathias Heikenwalder, Gabriele Saretzki, James Chapman, Sundeep Khosla, Mikolaj Ogrodnik, Bernadette Carroll, James L. Kirkland, Fiona Oakley
Publikováno v:
The EMBO Journal
e106048
The EMBO Journal, 2021, Vol.40(9), pp.e106048 [Peer Reviewed Journal]
EMBO Journal
Lagnado, A, Carroll, B, Passos, J F & al., E 2021, ' Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner ', EMBO Journal, vol. 40, no. 9, e106048 . https://doi.org/10.15252/embj.2020106048
e106048
The EMBO Journal, 2021, Vol.40(9), pp.e106048 [Peer Reviewed Journal]
EMBO Journal
Lagnado, A, Carroll, B, Passos, J F & al., E 2021, ' Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner ', EMBO Journal, vol. 40, no. 9, e106048 . https://doi.org/10.15252/embj.2020106048
Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro-inflammatory phenotype, thought to contribute to aging and age-related diseases. Neutrophils have essential roles in inflammatory responses; however, in certai
Autor:
Diana Jurk, Henrique Lemos, Derek A. Mann, João F. Passos, Dina Tiniakos, Kile Green, Bronte Elliott, Arianna Bianchi, Michele Vacca, Hannah L Paish, Zoe Hall, Caroline L. Wilson, Letizia Marchetti
Publikováno v:
The Journal of Immunology Author Choice
Key Points Moderate exercise reduces inflammaging, liver tumors, and chronic liver disease. Key molecular changes include lipid metabolism, oxidative damage, and senescence. Increased NAD+, sirtuin activity, and inflammatory and metabolic reprogrammi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f25430279b60ee59cce203a6ed06efb
http://hdl.handle.net/10044/1/85862
http://hdl.handle.net/10044/1/85862