Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Caroline L Ng"'
Autor:
Barbara H Stokes, Euna Yoo, James M Murithi, Madeline R Luth, Pavel Afanasyev, Paula C A da Fonseca, Elizabeth A Winzeler, Caroline L Ng, Matthew Bogyo, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007722 (2019)
Therapeutics with novel modes of action and a low risk of generating resistance are urgently needed to combat drug-resistant Plasmodium falciparum malaria. Here, we report that the peptide vinyl sulfones WLL-vs (WLL) and WLW-vs (WLW), highly selectiv
Externí odkaz:
https://doaj.org/article/f24fef1c12a441df9834313774f934c4
Autor:
Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Reto Brun, Ralf Brunner, Stephan Buchmann, Jeremy Burrows, Koen J Dechering, Michael Delves, Sonja Ewerling, Santiago Ferrer, Christoph Fischli, Francisco Javier Gamo-Benito, Nina F Gnädig, Bibia Heidmann, María Belén Jiménez-Díaz, Didier Leroy, Maria Santos Martínez, Solange Meyer, Joerg J Moehrle, Caroline L Ng, Rintis Noviyanti, Andrea Ruecker, Laura María Sanz, Robert W Sauerwein, Christian Scheurer, Sarah Schleiferboeck, Robert Sinden, Christopher Snyder, Judith Straimer, Grennady Wirjanata, Jutta Marfurt, Ric N Price, Thomas Weller, Walter Fischli, David A Fidock, Martine Clozel, Sergio Wittlin
Publikováno v:
PLoS Medicine, Vol 13, Iss 10, p e1002138 (2016)
BackgroundArtemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimala
Externí odkaz:
https://doaj.org/article/c760742987d34859b710bc8b89e29d3c
Autor:
Ioanna Deni, Barbara H. Stokes, Kurt E. Ward, Kate J. Fairhurst, Charisse Flerida A. Pasaje, Tomas Yeo, Shirin Akbar, Heekuk Park, Ryan Muir, Daniella S. Bick, Wenhu Zhan, Hao Zhang, Yi Jing Liu, Caroline L. Ng, Laura A. Kirkman, Jehad Almaliti, Alexandra E. Gould, Maëlle Duffey, Anthony J. O'Donoghue, Anne-Catrin Uhlemann, Jacquin C. Niles, Paula C.A. da Fonseca, William H. Gerwick, Gang Lin, Matthew Bogyo, David A. Fidock
Publikováno v:
Cell Chemical Biology. 30:470-485.e6
Autor:
Caroline L. Ng, Melissa R. Rosenthal
Publikováno v:
ACS Infectious Diseases. 7:1923-1931
Artemisinin-based combination therapies (ACTs), the World Health Organization-recommended first-line therapy for uncomplicated falciparum malaria, has led to significant decreases in malaria-associated morbidity and mortality in the past two decades.
Autor:
Melissa R. Rosenthal, Caroline L. Ng
Publikováno v:
SSRN Electronic Journal.
Autor:
Arpan Acharya, Caroline L. Ng, Siddappa N. Byrareddy, Anthony T. Podany, Shetty Ravi Dyavar, St Patrick Reid, Courtney V. Fletcher, Omalla A. Olwenyi
Publikováno v:
Journal of Molecular Medicine
Journal of Molecular Medicine (Berlin, Germany)
Journal of Molecular Medicine (Berlin, Germany)
Occasional zoonotic viral attacks on immunologically naive populations result in massive death tolls that are capable of threatening human survival. Currently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the infectious agent that ca
Autor:
Melissa R, Rosenthal, Caroline L, Ng
Publikováno v:
ACS Infect Dis
Artemisinin-based combination therapies (ACTs), the World Health Organization-recommended first-line therapy for uncomplicated falciparum malaria, has led to significant decreases in malaria-associated morbidity and mortality in the past two decades.
Autor:
Xiaoyi Deng, Gustavo A. Afanador, Marcus C. S. Lee, David A. Fidock, Caroline L. Ng, Aloysus K. Lawong, Pradipsinh K. Rathod, Jade Bath, Satish K. Dhingra, John H. White, Diana R. Tomchick, Farah El Mazouni, Margaret A. Phillips
Publikováno v:
ACS Infectious Diseases. 5:90-101
Malaria is one of the most challenging human infectious diseases and both prevention and control have been hindered by the development of Plasmodium falciparum resistance to existing therapies. Several new compounds with novel mechanisms are in clini
Publikováno v:
ACS Pharmacology & Translational Science
The coronavirus disease-2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 116 million individuals globally and resulted in over 2.5 million deaths since the first report in Decemb
Autor:
Arpan Acharya, St Patrick Reid, Kabita Pandey, Siddappa N. Byrareddy, Mahesh Mohan, Caroline L. Ng
Publikováno v:
Transbound Emerg Dis
Transboundary and Emerging Diseases
Transboundary and Emerging Diseases
Emerging and re-emerging viral diseases can create devastating effects on human lives and may also lead to economic crises. The ongoing COVID-19 pandemic due to the novel coronavirus (nCoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2