Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Caroline Kuiper"'
Autor:
Margreet C.M. Vissers, Peter H. Sykes, Margaret J. Currie, Gabi U. Dachs, Ilona G.M. Molenaar, Caroline Kuiper
Supplementary Table 1 from Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19a94fa12683c372edc27ed9287f88f
https://doi.org/10.1158/0008-5472.22382109.v1
https://doi.org/10.1158/0008-5472.22382109.v1
Autor:
Margreet C.M. Vissers, Peter H. Sykes, Margaret J. Currie, Gabi U. Dachs, Ilona G.M. Molenaar, Caroline Kuiper
Activation of the transcription factor hypoxia-inducible factor (HIF)-1 allows solid tumors to thrive under conditions of metabolic stress. Because HIF-1 is switched off by hydroxylation reactions that require ascorbate, inadequate intracellular asco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::547d7bfda2a61c3b07d172176e274104
https://doi.org/10.1158/0008-5472.c.6500103.v1
https://doi.org/10.1158/0008-5472.c.6500103.v1
Autor:
Margreet C.M. Vissers, Peter H. Sykes, Margaret J. Currie, Gabi U. Dachs, Ilona G.M. Molenaar, Caroline Kuiper
Supplementary Table 2 from Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1449c595d1fb10022e380c1a159d6d79
https://doi.org/10.1158/0008-5472.22382106
https://doi.org/10.1158/0008-5472.22382106
Autor:
Caroline Kuiper, Elisabeth Phillips, Christina Wohlrab, Bridget A. Robinson, Gabi U. Dachs, Margreet C.M. Vissers
Publikováno v:
Hypoxia. 7:17-31
Purpose: Protein levels and activity of the hypoxia-inducible transcription factors HIF-1 and HIF-2 are controlled by hydroxylation of the regulatory alpha chains. Proline hydroxylases (PHDs) target the protein for degradation via the von-Hippel-Lind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad5d54ede2cfb1cd2c6fd7c0fb60eda9
https://doi.org/10.2147/hp.s201643
https://doi.org/10.2147/hp.s201643
Publikováno v:
Cancer and Vitamin C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e190d73e1073ba9c1fe1421f9c2376c
https://doi.org/10.1201/9781003017493-4
https://doi.org/10.1201/9781003017493-4
Autor:
Christina, Wohlrab, Caroline, Kuiper, Margreet Cm, Vissers, Elisabeth, Phillips, Bridget A, Robinson, Gabi U, Dachs
Publikováno v:
Hypoxia
Purpose: Protein levels and activity of the hypoxia-inducible transcription factors HIF-1 and HIF-2 are controlled by hydroxylation of the regulatory alpha chains. Proline hydroxylases (PHDs) target the protein for degradation via the von-Hippel-Lind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed5f03fe7065ad7c1951fa46690f2961
https://pubmed.ncbi.nlm.nih.gov/31192266
https://pubmed.ncbi.nlm.nih.gov/31192266
Publikováno v:
Biochemical Society Transactions. 42:945-951
There is growing interest in the family of 2-OG (2-oxoglutarate)-dependent dioxygenase enzymes that catalyse the hydroxylation of a wide range of organic targets. Members of this family that regulate the cell's hypoxic response and epigenetic process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f20b3e857998b09c8474c1dd7069ec3
https://doi.org/10.1042/bst20140118
https://doi.org/10.1042/bst20140118
Publikováno v:
Free Radical Biology and Medicine. 69:308-317
Hypoxia-inducible factor (HIF)-1 drives the transcription of hundreds of genes to support cell survival under conditions of microenvironmental and metabolic stress. HIF-1 is downregulated by iron-containing 2-oxoglutarate-dependent enzymes that requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2a5635e925389ab91612e8848db8b1
https://doi.org/10.1016/j.freeradbiomed.2014.01.033
https://doi.org/10.1016/j.freeradbiomed.2014.01.033
Autor:
Margaret J. Currie, Caroline Kuiper, Ilona G. M. Molenaar, Gabi U. Dachs, Margreet C.M. Vissers, Peter Sykes
Publikováno v:
Cancer Research, 70(14), 5749-5758. AMER ASSOC CANCER RESEARCH
Activation of the transcription factor hypoxia-inducible factor (HIF)-1 allows solid tumors to thrive under conditions of metabolic stress. Because HIF-1 is switched off by hydroxylation reactions that require ascorbate, inadequate intracellular asco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4967fb91bfb75d0377752c93a0f529
https://doi.org/10.1158/0008-5472.CAN-10-0263
https://doi.org/10.1158/0008-5472.CAN-10-0263
Autor:
Margreet C.M. Vissers, Caroline Kuiper
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 4 (2014)
Frontiers in Oncology, Vol 4 (2014)
Ascorbate is a specific cofactor for a large family of enzymes known as the Fe- and 2-oxoglutarate-dependent dioxygenases. These enzymes are found throughout biology and catalyse the addition of a hydroxyl group to various substrates. The proline hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f150c073a67ffecf6bbbd4b433ec6f9
http://europepmc.org/articles/PMC4261134
http://europepmc.org/articles/PMC4261134