Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Caroline Kubaczka"'
Autor:
Jan Langkabel, Arik Horne, Lorenzo Bonaguro, Lisa Holsten, Tatiana Hesse, Alexej Knaus, Yannick Riedel, Matthias Becker, Kristian Händler, Tarek Elmzzahi, Kevin Bassler, Nico Reusch, Leon Harootoonovtch Yeghiazarian, Tal Pecht, Adem Saglam, Thomas Ulas, Anna C. Aschenbrenner, Franziska Kaiser, Caroline Kubaczka, Joachim L. Schultze, Hubert Schorle
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Synthetic embryo models have arisen as an approach to probe early development in vitro, facilitating the study of difficult to access stages. Here the authors present a simple system for generating embryo-like structures that resemble peri-implantati
Externí odkaz:
https://doaj.org/article/4777dcfcfbcb4d98ae83f5dc3f98bef3
Autor:
Franziska Kaiser, Julia Hartweg, Selina Jansky, Natalie Pelusi, Caroline Kubaczka, Neha Sharma, Dominik Nitsche, Jan Langkabel, Hubert Schorle
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5503 (2020)
Activating mutations in the human KIT receptor is known to drive severe hematopoietic disorders and tumor formation spanning various entities. The most common mutation is the substitution of aspartic acid at position 816 to valine (D816V), rendering
Externí odkaz:
https://doaj.org/article/b4b491f53e914c998ba69cd69754f6b5
Autor:
Caroline Kubaczka, Claire Senner, Marcos J. Araúzo-Bravo, Neha Sharma, Peter Kuckenberg, Astrid Becker, Andreas Zimmer, Oliver Brüstle, Michael Peitz, Myriam Hemberger, Hubert Schorle
Publikováno v:
Stem Cell Reports, Vol 2, Iss 2, Pp 232-242 (2014)
Trophoblast stem cells (TSCs) are in vitro equivalents to the precursor cells of the placenta. TSCs are cultured in serum-rich medium with fibroblast growth factor 4, heparin, and embryonic-fibroblast-conditioned medium. Here, we developed a simple m
Externí odkaz:
https://doaj.org/article/bf3b7ad7543542b0b80dc969a20137d6
Autor:
Edroaldo Lummertz da Rocha, Caroline Kubaczka, Wade W. Sugden, Mohamad Najia, Ran Jing, Arianna Markel, Zachary LeBlanc, Rafael dos Santos Peixoto, Marcelo Falchetti, James J. Collins, Trista E. North, George Q. Daley
Intercellular communication is important for tissue development and homeostasis, and when dysregulated contributes to a multitude of pathobiological processes. Cells communicate with each other by several mechanisms, including direct cell-cell contac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd37d56c6ecd55807eb2a3ea12a361aa
https://doi.org/10.21203/rs.3.pex-1843/v1
https://doi.org/10.21203/rs.3.pex-1843/v1
Autor:
Areum Han, Trista E. North, Nathaniel K. Mullin, Patricia Sousa, Edroaldo Lummertz da Rocha, Leonard I. Zon, Yuqi Tan, Thorsten M. Schlaeger, George Q. Daley, Samuel Landry, Patrick Cahan, Song Yang, Linda T. Vo, Yi Zhou, Yi Fen Lu, Deepak Kumar Jha, Minh Nguyen, Michael J. Chen, Caroline Kubaczka, Phoebe Hunter, Yuko Fujiwara
Publikováno v:
Stem Cell Reports
Summary Studies of hematopoietic stem cell (HSC) development from pre-HSC-producing hemogenic endothelial cells (HECs) are hampered by the rarity of these cells and the presence of other cell types with overlapping marker expression profiles. We gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1b4522e7c5b6ef6790d79118540006
https://doi.org/10.1016/j.stemcr.2020.03.020
https://doi.org/10.1016/j.stemcr.2020.03.020
Autor:
Franziska Kaiser, Nina Langer, Caroline Kubaczka, Lena Arévalo, Hubert Schorle, Jan Langkabel, Monika Graf
Publikováno v:
Placenta. 90:128-137
Introduction The first lineage separation in mammalian development occurs when totipotent cells of the zygote give rise to the inner cell mass and the trophectoderm. The lineages are strictly separated by an epigenetic barrier. In vitro derivatives o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3342c606049cb832279501f7fe6f88c4
https://doi.org/10.1016/j.placenta.2019.12.017
https://doi.org/10.1016/j.placenta.2019.12.017
Autor:
Edroaldo Lummertz da Rocha, Caroline Kubaczka, Wade W. Sugden, Mohamad Ali Najia, Ran Jing, Arianna Markel, Zachary C. LeBlanc, Rafael dos Santos Peixoto, Marcelo Falchetti, James J. Collins, Trista E. North, George Q. Daley
Publikováno v:
Nat Cell Biol
Intercellular communication orchestrates a multitude of physiologic and pathologic conditions. Algorithms to infer cell–cell communication and predict downstream signalling and regulatory networks are needed to illuminate mechanisms of stem cell di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c30540b8cb407f9e66d6c4797913fba
https://pubmed.ncbi.nlm.nih.gov/35414020
https://pubmed.ncbi.nlm.nih.gov/35414020
Autor:
Richard I. Gregory, Mehdi Pirouz, Daniel S. Pearson, Pavlos Missios, Amy S. Lee, George Q. Daley, Edroaldo Lummertz da Rocha, David T. Ting, Caroline Kubaczka, Kaloyan M. Tsanov, Joseph W. Franses, Daniel Dominguez, Brian Pepe-Mooney, Dorian Farache, John T. Powers, Deepak Kumar Jha, Julia Philipp, Maria M. Aleman
Publikováno v:
J Clin Invest
High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed that LIN28B expression was associated with enhanced cell migration in vitro and invasive and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a147bf052b2a9df3483dfea7d1212b52
https://doi.org/10.1172/jci145142
https://doi.org/10.1172/jci145142
Autor:
Ran Jing, Irene Scarfo, Mohamad Ali Najia, Edroaldo Lummertz da Rocha, Areum Han, Michael Sanborn, Trevor Bingham, Caroline Kubaczka, Deepak K. Jha, Marcelo Falchetti, Thorsten M. Schlaeger, Trista E. North, Marcela V. Maus, George Q. Daley
Publikováno v:
Cell Stem Cell. 29:1181-1196.e6
Human induced pluripotent stem cells (iPSCs) provide a potentially unlimited resource for cell therapies, but the derivation of mature cell types remains challenging. The histone methyltransferase EZH1 is a negative regulator of lymphoid potential du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4431ef8760157a3be53d0e7294e67b
https://doi.org/10.1016/j.stem.2022.06.014
https://doi.org/10.1016/j.stem.2022.06.014
Autor:
Nico Reusch, Kevin Bassler, Arik Horne, Alexej Knaus, Lorenzo Bonaguro, Tal Pecht, Kristian Händler, Caroline Kubaczka, Tatiana Hesse, Anna C. Aschenbrenner, Yannick Riedel, Leon Harootoonovtch Yeghiazarian, Hubert Schorle, Franziska Kaiser, Joachim L. Schultze, Jan Langkabel
SummaryBlastocyst-derived stem cell lines were shown to self-organize into embryo-like structures in 3D cell culture environments. Here, we provide evidence that synthetic embryo-like structures are generated solely based on transcription factor-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d864415cd2c62748542800cd9a84a02
https://doi.org/10.1101/2021.01.25.428068
https://doi.org/10.1101/2021.01.25.428068