Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Caroline K. Wang"'
Autor:
W. Ted Allison, Harley T. Kurata, Jingru Li, Richard Kanyo, Caroline K. Wang, Laszlo F. Locskai
Publikováno v:
Epilepsia. 61:1678-1690
Objective Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba94d83599b2cb200fb1e00be189b9a
https://doi.org/10.1111/epi.16592
https://doi.org/10.1111/epi.16592
Publikováno v:
The Journal of General Physiology
The KCNQ2-5 voltage-gated potassium channels are activated by a number of different compounds that shift the voltage dependence of activation to more negative voltages. Wang et al. show that pore- and voltage sensor–targeted activators have differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66112513bcb0eecc76f5be7973fa12c
https://doi.org/10.1085/jgp.201812070
https://doi.org/10.1085/jgp.201812070
Autor:
Stephan A. Pless, Harley T. Kurata, Nazlee Sharmin, Alice W. Wang, Caroline K. Wang, Runying Y. Yang, Michael C. Yau
Publikováno v:
The Journal of General Physiology
Kv7 potassium channels are strongly activated by a variety of small molecules with diverse mechanisms of action. Wang et al. investigate a compound that targets the voltage-sensing domain, ICA-069673, and demonstrate that four drug-sensitive subunits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c805c75ba6468cb21a7fe8e55a73553a
https://doi.org/10.1085/jgp.201812014
https://doi.org/10.1085/jgp.201812014
Autor:
Michael C. Yau, Harley T. Kurata, Stephan A. Pless, Jingru Li, Caroline K. Wang, Tarek Ammar, Robin Y. Kim, Runying Y. Yang
Publikováno v:
The Journal of General Physiology
Retigabine is a widely studied potassium channel activator that is thought to interact with a conserved Trp side chain in the pore domain of Kv7 subunits. Yau et al. demonstrate that drug sensitivity in just one of the four subunits is sufficient for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39544819c6edcf9fdb99741f437113fa
http://europepmc.org/articles/PMC6168243
http://europepmc.org/articles/PMC6168243
Publikováno v:
Biophysical Journal. 114:121a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9618873a8510be82df15dd1bec8cf6db
https://doi.org/10.1016/j.bpj.2017.11.693
https://doi.org/10.1016/j.bpj.2017.11.693
Publikováno v:
Biophysical Journal. 112:410a
Retigabine is the first approved anticonvulsant that acts via activation of KCNQ2-5 voltage-gated potassium channels, caused by a hyperpolarizing shift in the voltage-dependence of activation. An important unexplored feature of retigabine and its der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12371768bb4f150b46295f75388d8a47
https://doi.org/10.1016/j.bpj.2016.11.2555
https://doi.org/10.1016/j.bpj.2016.11.2555
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