Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Caroline K Buckway"'
Autor:
Ron G. Rosenfeld, Caroline K. Buckway, Jaime Guevara-Aguirre, K. L. Pratt, Christine P Burren
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 86:5176-5183
IGF-I generation tests were developed over 20 yr ago and are currently used in differentiating GH insensitivity (GHI) from other disorders characterized by low serum IGF-I. Nevertheless, generation tests have never been adequately characterized, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c5a7f311b7a1ba731f8524a85fc597
https://doi.org/10.1210/jcem.86.11.8019
https://doi.org/10.1210/jcem.86.11.8019
Autor:
Ron G. Rosenfeld, M. Ahlsén, Elizabeth M. Wilson, Caroline K. Buckway, Youngman Oh, Peter Bang
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 86:4943-4950
The N-terminal domain is conserved in all members of the IGF-binding protein superfamily. Most recently, studies have demonstrated the importance of an IGF-binding protein N-terminal hydrophobic pocket for IGF binding. To examine more critically the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29fc663600b7a4e45c557a16c9b9fef
https://doi.org/10.1210/jcem.86.10.7936
https://doi.org/10.1210/jcem.86.10.7936
Autor:
Caroline K. Buckway, Ron G. Rosenfeld
Publikováno v:
Hormone Research in Paediatrics. 55:36-39
The concept of growth hormone (GH) insensitivity has evolved since the condition was originally identified in 1966, and we now know that the primary defect involved is in the GH receptor. Cloning of the receptor molecule has led to great progress in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2713dc016abfd0e193048311088c42ef
https://doi.org/10.1159/000063472
https://doi.org/10.1159/000063472
Autor:
Ron G. Rosenfeld, Katherine A. Pratt, Brian M. Little, Liliana Bezrodnik, Juan J. Heinrich, Hector Jasper, Vivian Hwa, Eric M. Kofoed, Caroline K. Buckway, Junko Tsubaki, Alejandro Tepper, Katie A. Woods
Publikováno v:
Pediatric Nephrology. 20:303-305
Growth hormone insensitivity (GHI) has been attributable, classically, to mutations in the gene for the GH receptor. After binding to the GH receptor, GH initiates signal transduction through a number of pathways, including the JAK-STAT pathway. We d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9a05174339c6ec216a4cf4f527ed41
https://doi.org/10.1007/s00467-004-1678-7
https://doi.org/10.1007/s00467-004-1678-7
Publikováno v:
Hormone research. 62
Serum levels of growth hormone (GH)-dependent peptides could provide important and valuable measures of GH sensitivity and, potentially, responsiveness. In normal individuals, serum insulin-like growth factor I (IGF-I) concentrations are dependent on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b50b09de6941cc8eb593b5caa4e64e9
https://pubmed.ncbi.nlm.nih.gov/15761231
https://pubmed.ncbi.nlm.nih.gov/15761231
Autor:
Vivian Hwa, Eric M. Kofoed, Caroline K. Buckway, Ron G. Rosenfeld, Kathryn (Katie) Woods, Katherine L. Pratt, Brian M. Little
Publikováno v:
Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 14
Biochemical analysis indicates that the STAT-5b mutation affects signaling by both growth hormone (GH) and gamma-interferon. A patient with such a mutation thus manifests two new clinical disorders: (1) growth hormone insensitivity (GHI), which resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116c3374c61caa8f4f37d857c3e14c1c
https://pubmed.ncbi.nlm.nih.gov/15135774
https://pubmed.ncbi.nlm.nih.gov/15135774
Autor:
Kathryn (Katie) Woods, Junko Tsubaki, Vivian Hwa, Juan J. Heinrich, Brian M. Little, Katherine L. Pratt, Ron G. Rosenfeld, Hector Jasper, Liliana Bezrodnik, Eric M. Kofoed, Caroline K. Buckway, Alejandro Tepper
Publikováno v:
The New England journal of medicine. 349(12)
This report documents that the syndrome of growth hormone insensitivity (severe short stature, increased secretion of growth hormone, but low serum concentrations of insulin-like growth factor I [IGF-I] and IGF–binding protein 3) in a teenage girl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194bd323585280e0abf8fdc9473a28fd
https://pubmed.ncbi.nlm.nih.gov/13679524
https://pubmed.ncbi.nlm.nih.gov/13679524
Autor:
Caroline K. Buckway, William A. Horton, Ron G. Rosenfeld, Francesco Chiarelli, Charles T. Roberts, Lynda O'Rear, Anna Spagnoli, Vivian Hwa, Lara Longobardi, Monica Torello
Publikováno v:
Endocrinology. 144(5)
Chondrogenesis results from the condensation of mesenchymal chondroprogenitor cells (MCC) that proliferate and differentiate into chondrocytes. We have previously shown that IGF binding protein (IGFBP)-3 has an IGF-independent antiproliferative effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b22ff00c9fb3c375c6db7ca7c06e098
https://pubmed.ncbi.nlm.nih.gov/12697673
https://pubmed.ncbi.nlm.nih.gov/12697673
Autor:
Efi Tjoeng, Ron G. Rosenfeld, Caroline K. Buckway, Gary Sexton, Karin A. Selva, Jaime Guevara-Aguirre, Katherine L. Pratt
Publikováno v:
Hormone research. 60(5)
Background/Aim: Insulin-like growth factor I (IGF-I) and insulin-lke growth factor binding protein 3 (IGFBP-3) generation tests are both sensitive and specific measures of growth hormone (GH) sensitivity. Recently, the question of reproducibility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67af933bc260ba0c6acf4ebf0d6ccc50
https://pubmed.ncbi.nlm.nih.gov/14614229
https://pubmed.ncbi.nlm.nih.gov/14614229