Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Caroline J Bull"'
Autor:
Si Fang, James Yarmolinsky, Dipender Gill, Caroline J Bull, Claire M Perks, PRACTICAL Consortium, George Davey Smith, Tom R Gaunt, Tom G Richardson
Publikováno v:
PLoS Medicine, Vol 20, Iss 1, p e1003988 (2023)
BackgroundProstate cancer (PrCa) is the second most prevalent malignancy in men worldwide. Observational studies have linked the use of low-density lipoprotein cholesterol (LDL-c) lowering therapies with reduced risk of PrCa, which may potentially be
Externí odkaz:
https://doaj.org/article/03b395c4c5ce4616aa06673fae665de9
Autor:
Susan Martin, Jessica Tyrrell, E Louise Thomas, Matthew J Bown, Andrew R Wood, Robin N Beaumont, Lam C Tsoi, Philip E Stuart, James T Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc J Gunter, Caroline J Bull, Joshua A Bell, Emma E Vincent, Naveed Sattar, Malcolm G Dunlop, Ian PM Tomlinson, Sara Lindström, INVENT consortium, Jimmy D Bell, Timothy M Frayling, Hanieh Yaghootkar
Publikováno v:
eLife, Vol 11 (2022)
Background: Some individuals living with obesity may be relatively metabolically healthy, whilst others suffer from multiple conditions that may be linked to adverse metabolic effects or other factors. The extent to which the adverse metabolic compon
Externí odkaz:
https://doaj.org/article/6ad55c6d14b64beb84bf87baac62a5be
Autor:
Florence Guida, Vanessa Y Tan, Laura J Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D Stewart, Adam S Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano, Manuela M Bergmann, Caroline J Bull, Christina C Dahm, Audrey Gicquiau, Graham G Giles, Marc J Gunter, Toomas Haller, Arnulf Langhammer, Tricia L Larose, Börje Ljungberg, Andres Metspalu, Roger L Milne, David C Muller, Therese H Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A Rothwell, Augustin Scalbert, Julie A Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E Vincent, Melanie Waldenberger, Nicholas J Timpson, Mattias Johansson
Publikováno v:
PLoS Medicine, Vol 18, Iss 9, p e1003786 (2021)
BackgroundExcess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we sought to identify circulat
Externí odkaz:
https://doaj.org/article/e11457db8ee54250ba74852b65231bb7
Autor:
Andrei-Emil Constantinescu, David A. Hughes, Caroline J. Bull, Kathryn Fleming, Ruth E. Mitchell, Jie Zheng, Siddhartha Kar, Nicholas J. Timpson, Borko Amulic, Emma E. Vincent
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-15 (2024)
Abstract Background 'Benign ethnic neutropenia' (BEN) is a heritable condition characterized by lower neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic basis of BEN remains a subject of extensive research.
Externí odkaz:
https://doaj.org/article/076fa3065a87429d9b406f6aa47196de
Autor:
Danny N. Legge, Tracey J. Collard, Ewelina Stanko, Ashley J. Hoskin, Amy K. Holt, Caroline J. Bull, Madhu Kollareddy, Jake Bellamy, Sarah Groves, Eric H. Ma, Emma Hazelwood, David Qualtrough, Borko Amulic, Karim Malik, Ann C. Williams, Nicholas Jones, Emma E. Vincent
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102037- (2024)
Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthet
Externí odkaz:
https://doaj.org/article/b9bf09afa6cc4ffa9c8af160884748f0
Autor:
Andrei-Emil Constantinescu, Caroline J. Bull, Lucy J. Goudswaard, Jie Zheng, Benjamin Elsworth, Nicholas J. Timpson, Samantha F. Moore, Ingeborg Hers, Emma E. Vincent
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Deep vein thrombosis (DVT) is the formation of a blood clot in a deep vein. DVT can lead to a venous thromboembolism (VTE), the combined term for DVT and pulmonary embolism, a leading cause of death and disability worldwide. Despite the prev
Externí odkaz:
https://doaj.org/article/46d63e3cfff945c29f75b349c795307b
Autor:
Caroline J. Bull, Emma Hazelwood, Danny N. Legge, Laura J. Corbin, Tom G. Richardson, Matthew Lee, James Yarmolinsky, Karl Smith-Byrne, David A. Hughes, Mattias Johansson, Ulrike Peters, Sonja I. Berndt, Hermann Brenner, Andrea Burnett-Hartman, Iona Cheng, Sun-Seog Kweon, Loic Le Marchand, Li Li, Polly A. Newcomb, Rachel Pearlman, Alex McConnachie, Paul Welsh, Roy Taylor, Mike E.J. Lean, Naveed Sattar, Neil Murphy, Marc J. Gunter, Nicholas J. Timpson, Emma E. Vincent
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104977- (2024)
Summary: Background: Type 2 diabetes is associated with higher risk of several cancer types. However, the biological intermediates driving this relationship are not fully understood. As novel interventions for treating and managing type 2 diabetes be
Externí odkaz:
https://doaj.org/article/3d63fe39c9964f71a916b73ae2b08f11
Autor:
M. Celeste Simon, Nicolas Skuli, Ian A. Blair, Brian Keith, Emma E. Vincent, Nicholas J. Timpson, Daniela Mariosa, Stephen J. Chanock, Mark P. Purdue, Mattias Johansson, Paul Brennan, Jason Godfrey, Jimmy P. Xu, Elaine S. Ho, Madeleine Carens, Jennifer M. Finan, Clementina Mesaros, Caroline J. Bull, Romain Riscal
Figure S5 shows that targeting SCARB1 promotes ccRCC cell death in vitro and in vivo, related to Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c3f6e7eb011a08cd4d05b78f21af71
https://doi.org/10.1158/2159-8290.22540526.v1
https://doi.org/10.1158/2159-8290.22540526.v1
Autor:
M. Celeste Simon, Nicolas Skuli, Ian A. Blair, Brian Keith, Emma E. Vincent, Nicholas J. Timpson, Daniela Mariosa, Stephen J. Chanock, Mark P. Purdue, Mattias Johansson, Paul Brennan, Jason Godfrey, Jimmy P. Xu, Elaine S. Ho, Madeleine Carens, Jennifer M. Finan, Clementina Mesaros, Caroline J. Bull, Romain Riscal
Beta change in circulating metabolite per 1 log odds of RCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddc848f7d13761bcbee095a794194b4
https://doi.org/10.1158/2159-8290.22540514.v1
https://doi.org/10.1158/2159-8290.22540514.v1
Autor:
Caroline J. Bull, Emma Hazelwood, Joshua A. Bell, Vanessa Y. Tan, Andrei-Emil Constantinescu, Maria Carolina Borges, Danny N. Legge, Kimberly Burrows, Jeroen R. Huyghe, Hermann Brenner, Sergi Castellví-Bel, Andrew T Chan, Sun-Seog Kweon, Loic Le Marchand, Li Li, Iona Cheng, Rish K. Pai, Jane C. Figueiredo, Neil Murphy, Marc J. Gunter, Nicholas J. Timpson, Emma E. Vincent
Recognizing the early signs of cancer risk is vital for informing prevention, early detection, and survival. To investigate whether changes in circulating metabolites characterise the early stages of colorectal cancer (CRC) development, we examined a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2426c23f900766d2bbe3ec05c20f5a74
https://doi.org/10.1101/2023.03.10.23287084
https://doi.org/10.1101/2023.03.10.23287084