Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Caroline H Ko"'
Autor:
Hee-Kyung Hong, Jason L Chong, Weimin Song, Eun Joo Song, Amira A Jyawook, Andrew C Schook, Caroline H Ko, Joseph S Takahashi
Publikováno v:
PLoS Genetics, Vol 7, Iss 6 (2011)
Externí odkaz:
https://doaj.org/article/2d091caf26f644b7857ce28d28fa80db
Autor:
Caroline H Ko, Yujiro R Yamada, David K Welsh, Ethan D Buhr, Andrew C Liu, Eric E Zhang, Martin R Ralph, Steve A Kay, Daniel B Forger, Joseph S Takahashi
Publikováno v:
PLoS Biology, Vol 8, Iss 10, p e1000513 (2010)
Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circa
Externí odkaz:
https://doaj.org/article/20681a20116348f28b3deda1a36a0b56
Autor:
Hee-Kyung Hong, Jason L Chong, Weimin Song, Eun Joo Song, Amira A Jyawook, Andrew C Schook, Caroline H Ko, Joseph S Takahashi
Publikováno v:
PLoS Genetics, Vol 3, Iss 2, p e33 (2007)
The mechanism of circadian oscillations in mammals is cell autonomous and is generated by a set of genes that form a transcriptional autoregulatory feedback loop. While these "clock genes" are well conserved among animals, their specific functions re
Externí odkaz:
https://doaj.org/article/732c6ba0a69c4b6b9b2f099754a5b53c
Autor:
Howard Colman, Si Chen, C. David James, Laura Zuckerman, Olga Antipova, Margaret Schwartz, Daniel J. Brat, Junjing Deng, Dusten Unruh, Mitchell Glass, Caroline H. Ko, Rimas V. Lukas, Orin Bloch, Gayle E. Woloschak, Priya Kumthekar, Barry Lai, Ramana V. Davuluri, Fotini M. Kouri, Craig Horbinski, Borko Jovanovic, Tatjana Paunesku, Vinod Vijayakumar, Ray Lezon, Lisa A. Hurley, Miguel Muzzio, Nitya V. Sharma, Adam M. Sonabend, Francis J. Giles, Jeremy Heidel, Ann K. Adams, Matthew C. Tate, Serena Tommasini-Ghelfi, Luxi Li, Kathleen McCortney, Alexander H. Stegh, Manoj Kandpal, Karan Dixit
Publikováno v:
Science translational medicine, vol 13, iss 584
Sci Transl Med
Sci Transl Med
The lack of precision therapies combined with limited therapeutic access to intracranial tumor sites due to the presence of the blood-brain/blood-tumor barriers have contributed to glioblastoma (GBM) being one of the most difficult cancers to effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b32e3981c0cbcca50f68f14a1475576
https://escholarship.org/uc/item/5601p8jn
https://escholarship.org/uc/item/5601p8jn
Autor:
Samuel A. Jensen, Emily S. Day, Caroline H. Ko, Lisa A. Hurley, Janina P. Luciano, Fotini M. Kouri, Timothy J. Merkel, Andrea J. Luthi, Pinal C. Patel, Joshua I. Cutler, Weston L. Daniel, Alexander W. Scott, Matthew W. Rotz, Thomas J. Meade, David A. Giljohann, Chad A. Mirkin, Alexander H. Stegh
Publikováno v:
Spherical Nucleic Acids ISBN: 9780429200151
Spherical Nucleic Acids ISBN: 9781003056713
Spherical Nucleic Acids ISBN: 9781003056713
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e04c16c1bc01cc20d891ddf2b2981db
https://doi.org/10.4324/9780429200151-106
https://doi.org/10.4324/9780429200151-106
The effects of spherical nucleic acid (SNA) gold nanoparticle conjugates on the activation of macrophages in vitro and release of cytokines in vivo were explored. Herein, we show that G-quadruplexes, the formation of which is enhanced on gold nanopar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a1c4fac76b00ae24ec6a56705bc9c5
https://europepmc.org/articles/PMC6894393/
https://europepmc.org/articles/PMC6894393/
Autor:
Roger Stupp, Priya Kumthekar, Kathleen McCortney, Caroline H. Ko, Margaret Schwartz, Alfred Rademaker, Karan Dixit, Craig Horbinski, Alexander H. Stegh, Rimas V. Lukas, Laura Sharp, Adam M. Sonabend
Publikováno v:
Journal of Clinical Oncology. 37:3012-3012
3012 Background: Glioblastoma is a difficult to treat tumor with therapeutics limited by their ability to cross the blood brain barrier. SNAs, i.e., gold nanoparticle cores covalently conjugated with a corona of densely packed, highly oriented siRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32afa86573da1a29759534d345fb59e1
https://doi.org/10.1200/jco.2019.37.15_suppl.3012
https://doi.org/10.1200/jco.2019.37.15_suppl.3012
Publikováno v:
Chronobiology International. 30:540-547
We report that the neural representation of the time of day (time memory) in golden hamsters involves the setting of a 24-h oscillator that is functionally and anatomically distinct from the circadian clock in the suprachiasmatic nucleus (SCN), but i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e354ec686275edd1262925cd6e99681b
https://doi.org/10.3109/07420528.2012.754449
https://doi.org/10.3109/07420528.2012.754449
Autor:
C. Shad Thaxton, Pinal C. Patel, R. Kannan Mutharasan, Caroline H. Ko, Chad A. Mirkin, Andrea J. Luthi
Publikováno v:
Trends in Molecular Medicine. 16:553-560
Atherosclerosis is the disease mechanism responsible for coronary heart disease (CHD), the leading cause of death worldwide. One strategy to combat atherosclerosis is to increase the amount of circulating high density lipoproteins (HDL), which transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270355e2c371c0a380120ae10b4c0ca6
https://doi.org/10.1016/j.molmed.2010.10.006
https://doi.org/10.1016/j.molmed.2010.10.006
Publikováno v:
European Journal of Neuroscience. 25:3359-3366
Circadian activity rhythms in mammals are controlled by the expression and transcriptional regulation of clock genes in the suprachiasmatic nucleus (SCN). The circadian cycle length in hamsters is regulated in part by casein kinase I epsilon (CKIepsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c639620f69a1f20544883d6c9e3e2ea4
https://doi.org/10.1111/j.1460-9568.2007.05545.x
https://doi.org/10.1111/j.1460-9568.2007.05545.x