Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Caroline G. Lee"'
Autor:
Mulias Lian, Vivienne J. Tan, Riho Taguchi, Mingjue Zhao, Gui-Ping Phang, Arnold S. Tan, Shuling Liu, Caroline G. Lee, Samuel S. Chong
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8073 (2024)
Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a neurodegenerative disorder caused by the ATXN3 CAG repeat expansion. Preimplantation genetic testing for monogenic disorders (PGT-M) of SCA3/MJD should include reliable repeat exp
Externí odkaz:
https://doaj.org/article/3e51c8e9494d4f52a1ba306d24de690a
Autor:
Ashley J. W. Lim, C. Tera Tyniana, Lee Jin Lim, Justina Wei Lynn Tan, Ee Tzun Koh, TTSH Rheumatoid Arthritis Study Group, Samuel S. Chong, Chiea Chuen Khor, Khai Pang Leong, Caroline G. Lee
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background The popular statistics-based Genome-wide association studies (GWAS) have provided deep insights into the field of complex disorder genetics. However, its clinical applicability to predict disease/trait outcomes remains unclear as
Externí odkaz:
https://doaj.org/article/87deb690648f4aca92310084051267ce
Autor:
Brandon N. S. Ooi, Raechell, Ariel F. Ying, Yong Zher Koh, Yu Jin, Sherman W. L. Yee, Justin H. S. Lee, Samuel S. Chong, Jack W. C. Tan, Jianjun Liu, Caroline G. Lee, Chester L. Drum
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background:Statins can cause muscle symptoms resulting in poor adherence to therapy and increased cardiovascular risk. We hypothesize that combinations of potentially functional SNPs (pfSNPs), rather than individual SNPs, better predict myalgia in pa
Externí odkaz:
https://doaj.org/article/1ca09183fa1f478c835a6d92f24aa102
Publikováno v:
Vaccines, Vol 9, Iss 10, p 1141 (2021)
As the COVID-19 pandemic rages unabated, and with more infectious variants, vaccination may offer a way to transit out of strict restrictions on physical human interactions to curb the virus spread and prevent overwhelming the healthcare system. Howe
Externí odkaz:
https://doaj.org/article/0dcd8056830345c1a88912af1eefa676
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Myotonic dystrophy type 1 (DM1) is caused by expansion of the DMPK CTG trinucleotide repeat. Disease transmission to offspring can be avoided through prenatal diagnosis or preimplantation genetic testing for monogenic disorders (PGT-M). We describe a
Externí odkaz:
https://doaj.org/article/ca86324228c945819e6be6f05e426e86
Autor:
Cheryl Chan, Thomas Thurnherr, Jingbo Wang, Xavier Gallart-Palau, Siu Kwan Sze, Steve Rozen, Caroline G. Lee
Publikováno v:
Molecular Oncology, Vol 10, Iss 8, Pp 1183-1195 (2016)
Background The tumour suppressor p53 is a central player in transcription regulation and cell fate determination. By interacting with p53 and altering its sequence‐specific binding to the response elements, the hepatitis B virus X protein (HBx) was
Externí odkaz:
https://doaj.org/article/de6593f6dc574c418c0a7f668f0d17d5
Autor:
Caroline G. Lee, Oi Lian Kon, London Lucien Ooi, Samuel S. Chong, Sheng Lim, Feiyang Huang, Samuel Y.S. Wong, Lee Jin Lim
Next-generation sequencing has uncovered thousands of long noncoding RNAs (lncRNA). Many are reported to be aberrantly expressed in various cancers, including hepatocellular carcinoma (HCC), and play key roles in tumorigenesis. This review provides a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d323c535adb375a189c3587ae9e65745
https://doi.org/10.1158/0008-5472.c.6511284.v1
https://doi.org/10.1158/0008-5472.c.6511284.v1
Autor:
Caroline G. Lee, Oi Lian Kon, London Lucien Ooi, Samuel S. Chong, Sheng Lim, Feiyang Huang, Samuel Y.S. Wong, Lee Jin Lim
This file contains 4 supplementary figures (Figure S1, Figure S2, Figure S3 and Figure S4), 9 supplementary tables (Table S1,Table S2, Table S3A, Table S3B, Table S3C, Table S3D, Table S3E, Table S4A and Table S4B) and references used in the tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017b75be82ae4020feffcaf06047c463
https://doi.org/10.1158/0008-5472.22422603.v1
https://doi.org/10.1158/0008-5472.22422603.v1
Publikováno v:
Clinical Chemistry. 68:794-802
Background The autosomal dominantly inherited and genetically heterogeneous spinocerebellar ataxias (SCAs) exhibit highly similar clinical presentations. Many are caused by repeat expansions, of which at least 8 involve CAG repeats. Repeat expansion
Publikováno v:
The Journal of Molecular Diagnostics. 24:241-252
Methylated FMR1 full-mutation expansions cause fragile X syndrome. FMR1 premutation carriers are susceptible to other late-onset conditions, and women with premutation are at risk of transmitting a fully expanded FMR1 allele to offspring. Identificat