Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Caroline G Lee"'
Autor:
Mulias Lian, Vivienne J. Tan, Riho Taguchi, Mingjue Zhao, Gui-Ping Phang, Arnold S. Tan, Shuling Liu, Caroline G. Lee, Samuel S. Chong
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8073 (2024)
Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a neurodegenerative disorder caused by the ATXN3 CAG repeat expansion. Preimplantation genetic testing for monogenic disorders (PGT-M) of SCA3/MJD should include reliable repeat exp
Externí odkaz:
https://doaj.org/article/3e51c8e9494d4f52a1ba306d24de690a
Autor:
Han Chong Toh, Hanry Yu, Junzhe Zhao, NEO Shiyong, See Voon Seow, Timothy WH Shuen, Farah Tasnim, Antoinette SW Fong, Caroline G Lee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/9d4eb38d7dd84403b95f6b749dd28f7b
Autor:
Ashley J. W. Lim, C. Tera Tyniana, Lee Jin Lim, Justina Wei Lynn Tan, Ee Tzun Koh, TTSH Rheumatoid Arthritis Study Group, Samuel S. Chong, Chiea Chuen Khor, Khai Pang Leong, Caroline G. Lee
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background The popular statistics-based Genome-wide association studies (GWAS) have provided deep insights into the field of complex disorder genetics. However, its clinical applicability to predict disease/trait outcomes remains unclear as
Externí odkaz:
https://doaj.org/article/87deb690648f4aca92310084051267ce
Machine Learning Identifies a Signature of Nine Exosomal RNAs That Predicts Hepatocellular Carcinoma
Autor:
Josephine Yu Yan Yap, Laura Shih Hui Goh, Ashley Jun Wei Lim, Samuel S. Chong, Lee Jin Lim, Caroline G. Lee
Publikováno v:
Cancers, Vol 15, Iss 14, p 3749 (2023)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Although alpha fetoprotein (AFP) remains a commonly used serological marker of HCC, the sensitivity and specificity of AFP in detecting HCC is often limited.
Externí odkaz:
https://doaj.org/article/bc39361fd0854a84a98a0ce3be7be539
Autor:
Brandon N. S. Ooi, Raechell, Ariel F. Ying, Yong Zher Koh, Yu Jin, Sherman W. L. Yee, Justin H. S. Lee, Samuel S. Chong, Jack W. C. Tan, Jianjun Liu, Caroline G. Lee, Chester L. Drum
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background:Statins can cause muscle symptoms resulting in poor adherence to therapy and increased cardiovascular risk. We hypothesize that combinations of potentially functional SNPs (pfSNPs), rather than individual SNPs, better predict myalgia in pa
Externí odkaz:
https://doaj.org/article/1ca09183fa1f478c835a6d92f24aa102
Publikováno v:
Vaccines, Vol 9, Iss 10, p 1141 (2021)
As the COVID-19 pandemic rages unabated, and with more infectious variants, vaccination may offer a way to transit out of strict restrictions on physical human interactions to curb the virus spread and prevent overwhelming the healthcare system. Howe
Externí odkaz:
https://doaj.org/article/0dcd8056830345c1a88912af1eefa676
Autor:
Jian Han, Thomas Thurnherr, Alexander Y. F. Chung, Brian K. P. Goh, Pierce K. H. Chow, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Tony K. H. Lim, Samuel S. Chong, London L. P. J. Ooi, Caroline G. Lee
Publikováno v:
Cancers, Vol 13, Iss 11, p 2772 (2021)
Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. Here, we present a novel strategy to identify key circRNA signatures of clinically relevant co-expressed circRNA-mRNA networks in pertinent cancer-pathways that mo
Externí odkaz:
https://doaj.org/article/012de04d32c44f38a8e7a272f746c227
Autor:
Cheryl Chan, Thomas Thurnherr, Jingbo Wang, Xavier Gallart-Palau, Siu Kwan Sze, Steve Rozen, Caroline G. Lee
Publikováno v:
Molecular Oncology, Vol 10, Iss 8, Pp 1183-1195 (2016)
Background The tumour suppressor p53 is a central player in transcription regulation and cell fate determination. By interacting with p53 and altering its sequence‐specific binding to the response elements, the hepatitis B virus X protein (HBx) was
Externí odkaz:
https://doaj.org/article/de6593f6dc574c418c0a7f668f0d17d5
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Myotonic dystrophy type 1 (DM1) is caused by expansion of the DMPK CTG trinucleotide repeat. Disease transmission to offspring can be avoided through prenatal diagnosis or preimplantation genetic testing for monogenic disorders (PGT-M). We describe a
Externí odkaz:
https://doaj.org/article/ca86324228c945819e6be6f05e426e86
Autor:
Caroline G. Lee, Oi Lian Kon, London Lucien Ooi, Samuel S. Chong, Sheng Lim, Feiyang Huang, Samuel Y.S. Wong, Lee Jin Lim
Next-generation sequencing has uncovered thousands of long noncoding RNAs (lncRNA). Many are reported to be aberrantly expressed in various cancers, including hepatocellular carcinoma (HCC), and play key roles in tumorigenesis. This review provides a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d323c535adb375a189c3587ae9e65745
https://doi.org/10.1158/0008-5472.c.6511284.v1
https://doi.org/10.1158/0008-5472.c.6511284.v1