Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Caroline Freathy"'
Autor:
Hayley Farmer, Peter Charlton, Simon Cocks, Paul Depledge, Richard Faint, Irina Chuckowree, Deanne Thompson, Shouming Wang, Nan Chi Wan, Adrian Folkes, John W. Scott, Jan Broadbridge, Stewart J. Baker, John R. Harrison, Anthony Boyce, Sukhjit Sohal, Timothy Hancox, Warren Miller, Francis Xavier Wilson, Prakash Mistry, Caroline Freathy
Publikováno v:
Journal of Medicinal Chemistry. 47:1339-1350
In our continued effort to identify selective MRP1 modulators, we have developed two novel templates, 3 and 4, through rational drug design by identifying the key pharmacophore interaction at the 7-position of the pyrrolopyrimidine template 1. Furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0bee0b02b3618e536f0b7b91a6b068
https://doi.org/10.1021/jm0310129
https://doi.org/10.1021/jm0310129
Autor:
Ruth A. Roberts, Jean-Charles Gautier, Kelvin Cain, Caroline Freathy, Beth Coyle, Jean-François Léonard
Publikováno v:
Drug Metabolism Reviews. 35:269-275
When target organ toxicity arises in animal models during routine drug safety evaluation, it raises several key questions: Is this target organ toxicity related to the pharmacology? What is the mode of action (MOA)? Is the target organ toxicity relev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607bc5d478e1226cd163c1cf63c84fef
https://doi.org/10.1081/dmr-120026395
https://doi.org/10.1081/dmr-120026395
Autor:
Satinder Samra, Amanda Carys Harvey, Caroline Freathy, Neil Cross, Kathryn Baggott, Graham Place
Publikováno v:
Cancer Research. 77:B30-B30
Currently in vivo testing of animals is still the gold standard for drug development and testing of cytotoxic compounds. With the demand for non-animal alternatives raising here we compared the development and functionality of two 3D culture models f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d156f6331cc8fbe574e861fc36bf838
https://doi.org/10.1158/1538-7445.newfront17-b30
https://doi.org/10.1158/1538-7445.newfront17-b30
Publikováno v:
Hepatology. 32:750-760
In mammalian cells, non receptor-mediated apoptosis occurs via the cytochrome c-dependent assembly of a approximately 700-kd apoptotic protease-activating factor 1 (Apaf-1)/caspase-9 containing apoptosome complex. This initiates the postmitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7ad0f43f037dc14179db3abb3b6d5cf
https://doi.org/10.1053/jhep.2000.18329
https://doi.org/10.1053/jhep.2000.18329
Publikováno v:
Toxicology letters. 149(1-3)
Peroxisome proliferators (PPs) constitute a large and chemically diverse family of non-genotoxic rodent hepatocarcinogens that activate the PP-activated receptor alpha (PPARalpha). In order to investigate the hypothesis that PPs elicit their carcinog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072c0181f0c4079138eb8379867e3f59
https://pubmed.ncbi.nlm.nih.gov/15093246
https://pubmed.ncbi.nlm.nih.gov/15093246
Publikováno v:
The Journal of biological chemistry. 278(8)
We have previously shown that transforming growth factor-beta(1) (TGF-beta(1))-induced apoptosis in FaO hepatoma cells is mediated by cytochrome c release, apoptosome formation, and caspase activation. Although TGF-beta(1) acts via the SMAD signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec021239708d23f469b68af50e00198
https://pubmed.ncbi.nlm.nih.gov/12488458
https://pubmed.ncbi.nlm.nih.gov/12488458
Autor:
Kelvin Cain, Caroline Freathy
Publikováno v:
Toxicology letters. 120(1-3)
Transforming growth factor-beta1 (TGF-beta1), is involved in controlling liver size, by inducing apoptotic cell death in hepatocytes. However the mechanism by which TGF-beta(1) induces caspase activation and cell death is unknown. Apoptosis can be in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4806c46be07fc79bc7f87b1ad4f5b3d3
https://pubmed.ncbi.nlm.nih.gov/11323189
https://pubmed.ncbi.nlm.nih.gov/11323189
Autor:
Ruth A. Roberts, Cecile Michel, Eric Boitier, Jean-Charles Gautier, Beth Coyle, Caroline Freathy, Kelvin Cain
Publikováno v:
Toxicology Letters. 144:s19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::097756ea1e06219a77c66665ee55a9e7
https://doi.org/10.1016/s0378-4274(03)90060-9
https://doi.org/10.1016/s0378-4274(03)90060-9