An immunosuppressed microenvironment distinguishes lateral ventricle–contacting glioblastomas

Autor: Todd Bartkowiak, Sierra M. Lima, Madeline J. Hayes, Akshitkumar M. Mistry, Asa A. Brockman, Justine Sinnaeve, Nalin Leelatian, Caroline E. Roe, Bret C. Mobley, Silky Chotai, Kyle D. Weaver, Reid C. Thompson, Lola B. Chambless, Rebecca A. Ihrie, Jonathan M. Irish

Publikováno v: JCI Insight, Vol 8, Iss 12 (2023)

Radiographic contact of glioblastoma (GBM) tumors with the lateral ventricle and adjacent stem cell niche correlates with poor patient prognosis, but the cellular basis of this difference is unclear. Here, we reveal and functionally characterize dist

Externí odkaz: https://doaj.org/article/29907ada4aa143a69143033c5dcfd8c4

CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation

Autor: Kathryn E. Beckermann, Rachel Hongo, Xiang Ye, Kirsten Young, Katie Carbonell, Diana C. Contreras Healey, Peter J. Siska, Sierra Barone, Caroline E. Roe, Christof C. Smith, Benjamin G. Vincent, Frank M. Mason, Jonathan M. Irish, W. Kimryn Rathmell, Jeffrey C. Rathmell

Publikováno v: JCI Insight, Vol 5, Iss 16 (2020)

Metabolic reprogramming dictates the fate and function of stimulated T cells, yet these pathways can be suppressed in T cells in tumor microenvironments. We previously showed that glycolytic and mitochondrial adaptations directly contribute to reduci

Externí odkaz: https://doaj.org/article/862d5c6aeea34684826804171f88d2e8

Supplementary Table 1 from Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types

Autor: Jonathan M. Irish, Douglas B. Johnson, P. Brent Ferrell, Jeffrey C. Rathmell, Peter J. Siska, Vivian Gama, Mark C. Kelley, Megan L. Rasmussen, Nalin Leelatian, Kirsten E. Diggins, Caroline E. Roe, Deon B. Doxie, Brian K. Oberholtzer, Daniel D. McClanahan, Allison R. Greenplate

Supplementary Table 1 with updated patient sample information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ca253c019ffd581e72b5b98d054015
https://doi.org/10.1158/2326-6066.22536509.v1

Shared Resource Laboratory Operations: Changes Made During Initial Global COVID‐19 Lockdown of 2020

Autor: Cora H. Chadick, Caroline E. Roe, Rachael C. Walker, Jane Srivastava, Juan J. Garcia Vallejo, Radhika Patel, Eva Orlowski-Oliver, Jessica B. Back

Publikováno v: Cytometry
Cytometry Part A, 99(1), 22-32
Back, J B, Chadick, C H, Garcia Vallejo, J J, Orlowski-Oliver, E, Patel, R, Roe, C E, Srivastava, J & Walker, R V 2021, ' Shared Resource Laboratory Operations: Changes Made During Initial Global COVID-19 Lockdown of 2020 ', Cytometry Part A, vol. 99, no. 1, pp. 22-32 . https://doi.org/10.1002/cyto.a.24261

Undoubtedly, the global pandemic caused by the SARS‐CoV‐2 virus has had a significant impact on Shared Resource Laboratories (SRL) operations worldwide. Unlike other crises (e.g., natural disasters, acts of war, or terrorism) which often result i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63380a0db4d81b4c9b53fb84fb703230
http://europepmc.org/articles/PMC7898323

38 Spatial immune profiling of human glioblastoma tissue reveals the presence of aggregated lymphoid niches in the tumor microenvironment

Autor: Lola B. Chambless, Akshitkumar M. Mistry, Caroline E. Roe, Bret C. Mobley, Reid C. Thompson, Asa A. Brockman, Allison R. Greenplate, Jonathan M. Irish, Justine Sinnaeve, Madeline Hayes, Todd Bartkowiak, Nalin Leelatian, Rebecca A. Ihrie, Kyle D. Weaver, Sierra Barone

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundGlioblastomas (GBM) account for 60% of adult primary brain tumors. With few advances in therapeutics, median overall survival remains 15-months post-diagnosis. Immunotherapies may provide therapeutic benefit in GBM patients; however, no pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3589e0ae0a47260f08d8db9ce3c25011
https://doaj.org/article/ed3830b4d7f5480caf02ab6415ad6f00