Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Caroline E. Burns"'
Autor:
Mengmeng Huang, Alexander A. Akerberg, Xiaoran Zhang, Haejin Yoon, Shakchhi Joshi, Celia Hallinan, Christopher Nguyen, William T. Pu, Marcia C. Haigis, C. Geoffrey Burns, Caroline E. Burns
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The developmental mechanisms responsible for the structural defects observed in hypoplastic left heart syndrome remain controversial. Using rbfox-deficient zebrafish, the authors implicate impaired cardiac function as a primary driver of disease.
Externí odkaz:
https://doaj.org/article/9041cd9ac3304895ad0d0487ddc58fc6
Autor:
Maryline Abrial, Sandeep Basu, Mengmeng Huang, Vincent Butty, Asya Schwertner, Spencer Jeffrey, Daniel Jordan, Caroline E. Burns, C. Geoffrey Burns
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Aortic root aneurysm is a common cause of morbidity and mortality in Loeys-Dietz and Marfan syndromes, where perturbations in transforming growth factor beta (TGFβ) signaling play a causal or contributory role, respectively. Despite the advantages o
Externí odkaz:
https://doaj.org/article/560982aa1f5a477990b4927c8afac99d
Autor:
Michka Sharpe, Juan Manuel González-Rosa, Felicia Wranitz, Spencer Jeffrey, Katherine Copenhaver, C. Geoffrey Burns, Caroline E. Burns
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cardiomyocyte proliferation is an important source of new myocardium during heart development and regeneration. Consequently, mutations in drivers of cardiomyocyte proliferation cause congenital heart disease, and infarcted human hearts scar because
Externí odkaz:
https://doaj.org/article/82057a8af67d467ead765db37fcc9ae3
Autor:
Maryline Abrial, Noëlle Paffett-Lugassy, Spencer Jeffrey, Daniel Jordan, Evan O’Loughlin, Charles J. Frederick, III, C. Geoffrey Burns, Caroline E. Burns
Publikováno v:
Cell Reports, Vol 20, Iss 4, Pp 973-983 (2017)
The pharyngeal arch arteries (PAAs) are transient embryonic blood vessels that mature into critical segments of the aortic arch and its branches. Although defects in PAA development cause life-threating congenital cardiovascular defects, the molecula
Externí odkaz:
https://doaj.org/article/095379e7d24e4efbb768efc2e5efb6d0
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 10 (2019)
Although the zebrafish embryo is a powerful animal model of human heart failure, the methods routinely employed to monitor cardiac function produce rough approximations that are susceptible to bias and inaccuracies. We developed and validated a deep
Externí odkaz:
https://doaj.org/article/6cff5cf0a6d54d45b5a756cf7eb91110
Publikováno v:
Cold Spring Harbor perspectives in biology. 13(11)
Heart regeneration is a remarkable process whereby regrowth of damaged cardiac tissue rehabilitates organ anatomy and function. Unfortunately, the human heart is highly resistant to regeneration, which creates a shortage of cardiomyocytes in the wake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0177ce47c6c8ea9db6ca7b5c4405c91
https://pubmed.ncbi.nlm.nih.gov/34187805
https://pubmed.ncbi.nlm.nih.gov/34187805
Autor:
Alexander A. Akerberg, Michael Trembley, Vincent Butty, Asya Schwertner, Long Zhao, Manu Beerens, Xujie Liu, Mohammed Mahamdeh, Shiaulou Yuan, Laurie Boyer, Calum MacRae, Christopher Nguyen, William T. Pu, Caroline E. Burns, C. Geoffrey Burns
Publikováno v:
Circulation Research. 131:980-1000
Background: RBPs (RNA-binding proteins) perform indispensable functions in the post-transcriptional regulation of gene expression. Numerous RBPs have been implicated in cardiac development or physiology based on gene knockout studies and the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c804bb11d6c2499dbdd5e485d86911
https://doi.org/10.1161/circresaha.122.321728
https://doi.org/10.1161/circresaha.122.321728
Autor:
Michka Sharpe, Juan Manuel González-Rosa, Felicia Wranitz, Spencer Jeffrey, Katherine Copenhaver, C. Geoffrey Burns, Caroline E. Burns
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cardiomyocyte proliferation is an important source of new myocardium during heart development and regeneration. Consequently, mutations in drivers of cardiomyocyte proliferation cause congenital heart disease, and infarcted human hearts scar because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd088ac82f46e5d10c62813215d6e9cf
https://pubmed.ncbi.nlm.nih.gov/35178388
https://pubmed.ncbi.nlm.nih.gov/35178388
Publikováno v:
Pediatr Cardiol
Numerous RNA-binding proteins (RBPs) are expressed in the heart, and mutations in several RBPs have been implicated in cardiovascular disease through genetic associations, animal modeling, and mechanistic studies. However, the functions of many more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf088ca7d992cdd27207b83ba0d8918c
https://doi.org/10.1007/s00246-019-02180-6
https://doi.org/10.1007/s00246-019-02180-6
Autor:
Mohammed Mahamdeh, Lijun Zhou, Shiaulou Yuan, Trembley M, Christopher Nguyen, Schwertner A, William T. Pu, Caroline E. Burns, Beerens M, Butty, Burns Cg, Liu X, Alexander A. Akerberg, Calum A. MacRae
RationaleThe identification of novel cardiomyocyte-intrinsic factors that support heart function will expand the number of candidate genes and therapeutic options for heart failure, a leading cause of death worldwide.ObjectiveTo identify and characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c32e7c065638bc90d02a7aeffb20b33b
https://doi.org/10.1101/2021.03.08.434502
https://doi.org/10.1101/2021.03.08.434502
