Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Caroline E Zetterström"'
Autor:
Caroline E Zetterström, Jenny Hasselgren, Olli Salin, Rohan A Davis, Ronald J Quinn, Charlotta Sundin, Mikael Elofsson
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81969 (2013)
Society faces huge challenges, as a large number of bacteria have developed resistance towards many or all of the antibiotics currently available. Novel strategies that can help solve this problem are urgently needed. One such strategy is to target b
Externí odkaz:
https://doaj.org/article/2818f80a2b4c4cb48cf9cd6861b541ca
Autor:
Mads Gabrielsen, Katherine S H Beckham, Victoria A Feher, Caroline E Zetterström, Dai Wang, Sylke Müller, Mikael Elofsson, Rommie E Amaro, Olwyn Byron, Andrew J Roe
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32217 (2012)
Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced sta
Externí odkaz:
https://doaj.org/article/f1d1bcf768034b47ad2805c83446d23a
Autor:
Mikael Elofsson, Charlotta Sundin, Robert Brkljača, Sylvia Urban, Duc Duy Vo, Caroline E. Zetterström
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Bacterial infections continue to threaten humankind and the rapid spread of antibiotic resistant bacteria is alarming. Current antibiotics target essential bacterial processes and thereby apply a strong selective pressure on pathogenic and non-pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3816a63165bddd50d6486467007bb68d
https://doi.org/10.1038/s41598-020-58872-0
https://doi.org/10.1038/s41598-020-58872-0
Autor:
Shannon Hinch, Weixing Qian, Pia Uusitalo, Christin Grundström, Rémi Caraballo, Mikael Elofsson, Caroline E. Zetterström
Publikováno v:
SLAS Discovery. 23:815-822
Acetaldehyde dehydrogenase (AdhE) is a bifunctional acetaldehyde-coenzyme A (CoA) dehydrogenase and alcohol dehydrogenase involved in anaerobic metabolism in gram-negative bacteria. This enzyme was recently found to be a key regulator of the type thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81d991ec7a267364f239533dfa47248
https://doi.org/10.1177/2472555218768062
https://doi.org/10.1177/2472555218768062
Autor:
Ellena M. Peterson, Tofeeq Ur-Rehman, Hencelyn Chu, Markus K. Dahlgren, Åsa Gylfe, Caroline E. Zetterström, Anders Blomgren, Anatoly Slepenkin, Mikael Elofsson
Publikováno v:
Ur-Rehman, T; Slepenkin, A; Chu, H; Blomgren, A; Dahlgren, MK; Zetterström, CE; et al.(2012). Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion. Journal of Antibiotics, 65(8), 397-404. doi: 10.1038/ja.2012.43. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/19x581zz
The Journal of Antibiotics
The Journal of Antibiotics
Salicylidene acylhydrazides belong to a class of compounds shown to inhibit bacterial type III secretion (T3S) in pathogenic Gram-negative bacteria. This class of compounds also inhibits growth and replication of Chlamydiae, strict intracellular bact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9a418c7c1053384e499de4e8a0500b
https://doi.org/10.1038/ja.2012.43
https://doi.org/10.1038/ja.2012.43
Autor:
Timothy J. Mitchell, Andrew J. Roe, Hanna Uvell, Arvind Mahajan, Mads Gabrielsen, Dai Wang, Olwyn Byron, Richard Burchmore, Katherine S. H. Beckham, Sarah MacDonald, Caroline E. Zetterström, Pawel Herzyk, Brian O. Smith, Mikael Elofsson, Jai J. Tree, David L. Gally
Publikováno v:
The Journal of Biological Chemistry
Wang, D, Zetterstrom, C E, Gabrielsen, M, Beckham, K S, Tree, J J, Macdonald, S E, Byron, O, Mitchell, T J, Gally, D L, Herzyk, P, Mahajan, A, Uvell, H, Burchmore, R, Smith, B O, Elofsson, M & Roe, A J 2011, ' Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds ', Journal of Biological Chemistry, vol. 286, no. 34, pp. 29922-29931 . https://doi.org/10.1074/jbc.M111.233858
Wang, D, Zetterstrom, C E, Gabrielsen, M, Beckham, K S, Tree, J J, Macdonald, S E, Byron, O, Mitchell, T J, Gally, D L, Herzyk, P, Mahajan, A, Uvell, H, Burchmore, R, Smith, B O, Elofsson, M & Roe, A J 2011, ' Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds ', Journal of Biological Chemistry, vol. 286, no. 34, pp. 29922-29931 . https://doi.org/10.1074/jbc.M111.233858
A class of anti-virulence compounds, the salicylidene acylhydrazides, have been widely reported to block the function of the type three secretion system of several Gram-negative pathogens by a previously unknown mechanism. In this work, we provide th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b5dceeb19b39bc22b7f81bc5ef1953
http://europepmc.org/articles/PMC3191033
http://europepmc.org/articles/PMC3191033
Autor:
Dai Wang, Neil W. Isaacs, Andrew J. Roe, Caroline E. Zetterström, Katherine S. H. Beckham, Mikael Elofsson, Mads Gabrielsen
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 66:1606-1609
Thiol peroxidase is an atypical 2-Cys peroxiredoxin that reduces alkyl hydroperoxides. Wild-type and C61S mutant protein have been recombinantly expressed in Escherichia coli and purified using nickel-affinity chromatography. Initial crystallization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb99049ea701055ea3a37789b4ea670
https://doi.org/10.1107/s1744309110039679
https://doi.org/10.1107/s1744309110039679
Autor:
Tofeeq, Ur-Rehman, Roland, Nordfelth, Anders, Blomgren, Caroline E, Zetterström, Mikael, Elofsson, Asa, Gylfe
Publikováno v:
Advances in experimental medicine and biology. 954
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ebd18000f4bebcf7da9d5a8df74bd1f
https://pubmed.ncbi.nlm.nih.gov/22782781
https://pubmed.ncbi.nlm.nih.gov/22782781
Autor:
Rommie E. Amaro, Mads Gabrielsen, Sylke Müller, Mikael Elofsson, Dai Wang, Olwyn Byron, Caroline E. Zetterström, Victoria A. Feher, Katherine S. H. Beckham, Andrew J. Roe
Publikováno v:
Gabrielsen, Mads; Beckham, Katherine H.; Feher, Victoria A.; Zetterstrom, Caroline E.; Wang, Dai; Muller, Sylke; et al.(2012). Structural Characterisation of Tpx from Yersinia pseudotuberculosis Reveals Insights into the Binding of Salicylidene Acylhydrazide Compounds. PLoS ONE, 7(2), e32217. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3bj5h4w9
PLoS ONE, Vol 7, Iss 2, p e32217 (2012)
PLoS ONE
PLoS ONE, Vol 7, Iss 2, p e32217 (2012)
PLoS ONE
Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1edb11ab8551e296ad1b1480a0803f85
http://www.escholarship.org/uc/item/3bj5h4w9
http://www.escholarship.org/uc/item/3bj5h4w9
Autor:
Åsa Gylfe, Roland Nordfelth, Tofeeq Ur-Rehman, Anders Blomgren, Mikael Elofsson, Caroline E. Zetterström
Publikováno v:
Advances in Yersinia Research ISBN: 9781461435600
Bacterial virulence inhibitors are potential novel drugs that may be used to treat infections. N′-(3,5-dibromo-2-hydroxy-benzylidene)-nicotinic acid hydrazide, ME0052, has been shown to inhibit type III secretion (T3S) and virulence in several Gram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616bbdb5e323d639c93b798d1b59081f
https://doi.org/10.1007/978-1-4614-3561-7_42
https://doi.org/10.1007/978-1-4614-3561-7_42