Zobrazeno 1 - 10
of 524
pro vyhledávání: '"Caroline Dive"'
Autor:
Robert E. Hynds, Ariana Huebner, David R. Pearce, Mark S. Hill, Ayse U. Akarca, David A. Moore, Sophia Ward, Kate H. C. Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A. Wilson, Oriol Pich, Carlos Martínez-Ruiz, A. S. Md Mukarram Hossain, Simon P. Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak Chandrasekharan, Krishna K. Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E. Cook, Leticia Bosshard-Carter, Cristina Naceur-Lombardelli, Andrew J. Rowan, Selvaraju Veeriah, Kevin Litchfield, Philip A. J. Crosbie, Caroline Dive, Sergio A. Quezada, Sam M. Janes, Mariam Jamal-Hanjani, Teresa Marafioti, TRACERx consortium, Nicholas McGranahan, Charles Swanton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled in the TRACERx study. Multi-regio
Externí odkaz:
https://doaj.org/article/15a9cb6171ca46d4a07fbfbe6bf74b76
Autor:
Alicia-Marie Conway, Simon P. Pearce, Alexandra Clipson, Steven M. Hill, Francesca Chemi, Dan Slane-Tan, Saba Ferdous, A. S. Md Mukarram Hossain, Katarzyna Kamieniecka, Daniel J. White, Claire Mitchell, Alastair Kerr, Matthew G. Krebs, Gerard Brady, Caroline Dive, Natalie Cook, Dominic G. Rothwell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Cancers of Unknown Primary (CUP) remains a diagnostic and therapeutic challenge due to biological heterogeneity and poor responses to standard chemotherapy. Predicting tissue-of-origin (TOO) molecularly could help refine this diagnosis, with
Externí odkaz:
https://doaj.org/article/d4bcd616a1c54d2c97e8ef0bccad3ec9
Autor:
Jiyoun Seo, Mihir Kumar, Jeremy Mason, Fiona Blackhall, Nicholas Matsumoto, Caroline Dive, James Hicks, Peter Kuhn, Stephanie N. Shishido
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with low five-year survival rates. Recently described molecular phenotypes of SCLC exhibit differential vulnerabilities heralding potential for stratified treatment. Whilst
Externí odkaz:
https://doaj.org/article/848e7fb37b224161b13db53d8e9f0b96
Autor:
Mieke Van Hemelrijck, Chris Brew-Graves, Neil McCartan, Louise Brown, Manuel Rodriguez-Justo, Aiman Haider, Alex Freeman, Mark Emberton, Kingshuk Pal, William Maynard, Aida Santaolalla, Nora Pashayan, Malcolm Mason, Tom Syer, Chris Parker, Caroline M Moore, Charlotte Bevan, Jayshireen Singh, Stuart Mackay-Thomas, Kate Walters, Mehul Mathukia, Charlotte Moss, David Sharpe, Kinnari Naik, Thomas Callender, Andrew Feber, Lee Berney, Anwar Padhani, Shonit Punwani, Hashim U Ahmed, Richard Kaplan, Teresa Marsden, Joanna Hadley, Steve Tuck, Saran Green, Ton Coolen, Elizabeth Isaac, Giorgio Brembilla, Douglas Kopcke, Francesco Giganti, Gerhardt Attard, Hina Pervez, Eric Aboagye, Elena Frangou, Fiona Gong, Louise C Brown, Aida Santa Olalla, Rosie Clow, Ged Corbett, Anna Wingate, Fatima Akbar, Suparna Thakali, Ashling Henderson, Dizem Tekin, Joey Clement, Harbit Sidhu, Teresita Beeston, Katerina Soteriou, Francesca Rawlins, Pirruntha Sivaharan, Savahnna Wolfe, Henry Tam, Heather Bholastewart, Sarp Keskin, Mariana Bertoncelli, Paul Boutros, Hayley Whitaker, Caroline Dive, Eytan Domany, Peter Parker, Andrew Prugia, Claire Chalmers-Watson, Alexander Gilkes, Dr Hira
Publikováno v:
BMJ Oncology, Vol 2, Iss 1 (2023)
Objective In men with a raised prostate-specific antigen (PSA), MRI increases the detection of clinically significant cancer and reduces overdiagnosis, with fewer biopsies. MRI as a screening tool has not been assessed independently of PSA in a forma
Externí odkaz:
https://doaj.org/article/9e67b1d6c59a4ab9a2b0588957b411c1
Autor:
Ian G. Cannell, Kirsty Sawicka, Isabella Pearsall, Sophia A. Wild, Lauren Deighton, Sarah M. Pearsall, Giulia Lerda, Fadwa Joud, Showkhin Khan, Alejandra Bruna, Kathryn L. Simpson, Claire M. Mulvey, Fiona Nugent, Fatime Qosaj, Dario Bressan, Caroline Dive, Carlos Caldas, Gregory J. Hannon
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112791- (2023)
Summary: Vasculogenic mimicry (VM) describes the formation of pseudo blood vessels constructed of tumor cells that have acquired endothelial-like properties. VM channels endow the tumor with a tumor-derived vascular system that directly connects to h
Externí odkaz:
https://doaj.org/article/f390fa24956d4ab7a84bdc36669be9b9
Autor:
Matthew Roberts, Julia Ogden, AS Mukarram Hossain, Anshuman Chaturvedi, Alastair RW Kerr, Caroline Dive, Jennifer Ellen Beane, Carlos Lopez-Garcia
Publikováno v:
eLife, Vol 12 (2023)
Lung squamous cell carcinoma (LUSC) is a type of lung cancer with a dismal prognosis that lacks adequate therapies and actionable targets. This disease is characterized by a sequence of low- and high-grade preinvasive stages with increasing probabili
Externí odkaz:
https://doaj.org/article/2b5e28916d8849bba8c6613fd630731c
Autor:
Andi K. Cani, Emily M. Dolce, Elizabeth P. Darga, Kevin Hu, Chia‐Jen Liu, Jackie Pierce, Kieran Bradbury, Elaine Kilgour, Kimberly Aung, Gaia Schiavon, Danielle Carroll, T. Hedley Carr, Teresa Klinowska, Justin Lindemann, Gayle Marshall, Vicky Rowlands, Elizabeth A. Harrington, J. Carl Barrett, Nitharsan Sathiyayogan, Christopher Morrow, Valeria Sero, Anne C. Armstrong, Richard Baird, Erika Hamilton, Seock‐Ah Im, Komal Jhaveri, Manish R. Patel, Caroline Dive, Scott A. Tomlins, Aaron M. Udager, Daniel F. Hayes, Costanza Paoletti
Publikováno v:
Molecular Oncology, Vol 16, Iss 10, Pp 1969-1985 (2022)
Nearly all estrogen receptor (ER)‐positive (POS) metastatic breast cancers become refractory to endocrine (ET) and other therapies, leading to lethal disease presumably due to evolving genomic alterations. Timely monitoring of the molecular events
Externí odkaz:
https://doaj.org/article/3982ed92674c47fd83894acff6f5a9d3
Autor:
Yan Ting Shue, Alexandros P. Drainas, Nancy Yanzhe Li, Sarah M. Pearsall, Derrick Morgan, Nasa Sinnott-Armstrong, Susan Q. Hipkins, Garry L. Coles, Jing Shan Lim, Anthony E. Oro, Kathryn L. Simpson, Caroline Dive, Julien Sage
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Notch signaling is known to control neuroendocrine fate in the lungs. Shue and colleagues further identify the REST and YAP transcriptional regulators as key components of the Notch signaling pathway in the control of the neuroendocrine cell fate in
Externí odkaz:
https://doaj.org/article/26be3ba323444a888bbc657c28aa7b6e
Autor:
Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (C
Externí odkaz:
https://doaj.org/article/a99beedee95f4504bd782063edbc7711
Autor:
Reem D. Mahmood, Danielle Shaw, Tine Descamps, Cong Zhou, Robert D. Morgan, Saifee Mullamitha, Mark Saunders, Nerissa Mescallado, Alison Backen, Karen Morris, Ross A. Little, Susan Cheung, Yvonne Watson, James P. B. O’Connor, Alan Jackson, Geoff J. M. Parker, Caroline Dive, Gordon C. Jayson
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Patients with metastatic colorectal cancer are treated with cytotoxic chemotherapy supplemented by molecularly targeted therapies. There is a critical need to define biomarkers that can optimise the use of these therapies to maxim
Externí odkaz:
https://doaj.org/article/357e10ddf5c4403488351151c9365ef5