Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Caroline Dalgliesh"'
Autor:
Chileleko Siachisumo, Sara Luzzi, Saad Aldalaqan, Gerald Hysenaj, Caroline Dalgliesh, Kathleen Cheung, Matthew R Gazzara, Ivaylo D Yonchev, Katherine James, Mahsa Kheirollahi Chadegani, Ingrid E Ehrmann, Graham R Smith, Simon J Cockell, Jennifer Munkley, Stuart A Wilson, Yoseph Barash, David J Elliott
Publikováno v:
eLife, Vol 12 (2024)
Previously, we showed that the germ cell-specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility (Ehrmann et al., 2019). Here, we show that in somatic cells the similar yet ubiquitously ex
Externí odkaz:
https://doaj.org/article/3a7024d8f2914f8397cd755d8a9c8c64
Autor:
Ingrid Ehrmann, Matthew R. Gazzara, Vittoria Pagliarini, Caroline Dalgliesh, Mahsa Kheirollahi-Chadegani, Yaobo Xu, Eleonora Cesari, Marina Danilenko, Marie Maclennan, Kate Lowdon, Tanja Vogel, Piia Keskivali-Bond, Sara Wells, Heather Cater, Philippe Fort, Mauro Santibanez-Koref, Silvia Middei, Claudio Sette, Gavin J. Clowry, Yoseph Barash, Mark O. Cunningham, David J. Elliott
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3269-3280 (2016)
The brain is made up of trillions of synaptic connections that together form neural networks needed for normal brain function and behavior. SLM2 is a member of a conserved family of RNA binding proteins, including Sam68 and SLM1, that control splicin
Externí odkaz:
https://doaj.org/article/f0ae21a2845440f5b5bb4825a77a395e
Autor:
Jennifer Munkley, Ling Li, S R Gokul Krishnan, Gerald Hysenaj, Emma Scott, Caroline Dalgliesh, Htoo Zarni Oo, Teresa Mendes Maia, Kathleen Cheung, Ingrid Ehrmann, Karen E Livermore, Hanna Zielinska, Oliver Thompson, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna W Harries, Mads Daugaard, Simon Cockell, Nuno L Barbosa-Morais, Sebastian Oltean, David J Elliott
Publikováno v:
eLife, Vol 8 (2019)
Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT). Androgens control transcription by stimulating androgen receptor (AR) activity, yet al
Externí odkaz:
https://doaj.org/article/4a90da626b1545618d58b1a38a177512
Autor:
Mikael Feracci, Jaelle N. Foot, Sushma N. Grellscheid, Marina Danilenko, Ralf Stehle, Oksana Gonchar, Hyun-Seo Kang, Caroline Dalgliesh, N. Helge Meyer, Yilei Liu, Albert Lahat, Michael Sattler, Ian C. Eperon, David J. Elliott, Cyril Dominguez
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Sam68 and T-STAR are members of the STAR family of proteins, which regulate various aspects of RNA metabolism. Here, the authors reveal structural features required for alternative splicing regulation by these proteins.
Externí odkaz:
https://doaj.org/article/b392828e149940d59b95a44e32da32fa
Autor:
Ingrid Ehrmann, Caroline Dalgliesh, Yilei Liu, Marina Danilenko, Moira Crosier, Lynn Overman, Helen M Arthur, Susan Lindsay, Gavin J Clowry, Julian P Venables, Philippe Fort, David J Elliott
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003474 (2013)
The RNA binding protein T-STAR was created following a gene triplication 520-610 million years ago, which also produced its two parologs Sam68 and SLM-1. Here we have created a T-STAR null mouse to identify the endogenous functions of this RNA bindin
Externí odkaz:
https://doaj.org/article/f864fa3a2be147ddafb7de7d8ed2a028
Autor:
Sushma Grellscheid, Caroline Dalgliesh, Markus Storbeck, Andrew Best, Yilei Liu, Miriam Jakubik, Ylva Mende, Ingrid Ehrmann, Tomaz Curk, Kristina Rossbach, Cyril F Bourgeois, James Stévenin, David Grellscheid, Michael S Jackson, Brunhilde Wirth, David J Elliott
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002390 (2011)
Alternative splicing amplifies the information content of the genome, creating multiple mRNA isoforms from single genes. The evolutionarily conserved splicing activator Tra2β (Sfrs10) is essential for mouse embryogenesis and implicated in spermatoge
Externí odkaz:
https://doaj.org/article/20c4e94289de4e048a6e69de9a18720f
Autor:
Prabhakar Rajan, Caroline Dalgliesh, Phillippa J Carling, Thomas Buist, Chaolin Zhang, Sushma N Grellscheid, Kelly Armstrong, Jacqueline Stockley, Cedric Simillion, Luke Gaughan, Gabriela Kalna, Michael Q Zhang, Craig N Robson, Hing Y Leung, David J Elliott
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29088 (2011)
Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global
Externí odkaz:
https://doaj.org/article/8837ff026e9b4d53be7ae6437b1015ed
Autor:
Saad Aldalaqan, Caroline Dalgliesh, Sara Luzzi, Chileleko Siachisumo, Louise N Reynard, Ingrid Ehrmann, David J. Elliott
Publikováno v:
Cell Cycle. 21:219-227
High levels of transcription and alternative splicing are recognized hallmarks of gene expression in the testis and largely driven by cells in meiosis. Because of this, the male meiosis stage of the cell cycle is often viewed as having a relatively p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c4dee82e0617b748ac59624b5976d0
https://doi.org/10.1080/15384101.2021.2015672
https://doi.org/10.1080/15384101.2021.2015672
Autor:
Francis Ramond, Caroline Dalgliesh, Mona Grimmel, Oded Wechsberg, Annalisa Vetro, Renzo Guerrini, David FitzPatrick, Rebecca L. Poole, Marine Lebrun, Allan Bayat, Ute Grasshoff, Miriam Bertrand, Dennis Witt, Peter D. Turnpenny, Víctor Faundes, Lorena Santa María, Carolina Mendoza Fuentes, Paulina Mabe, Shaun A. Hussain, Sureni V. Mullegama, Erin Torti, Barbara Oehl-Jaschkowitz, Lina Basel Salmon, Naama Orenstein, Noa Ruhrman Shahar, Ofir Hagari, Lily Bazak, Sabine Hoffjan, Carlos E. Prada, Tobias Haack, David J. Elliott
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics.
Transformer2 proteins (Tra2α and Tra2β) control splicing patterns in human cells, and no human phenotypes have been associated with germline variants in these genes. The aim of this work was to associate germline variants in the TRA2B gene to a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e301c8aa682aa7ec544e815c8ac1619
https://pubmed.ncbi.nlm.nih.gov/36549593
https://pubmed.ncbi.nlm.nih.gov/36549593
Autor:
Sara Luzzi, Jennifer Munkley, Kathleen Cheung, Matthew R. Gazzara, Chileleko Siachisumo, Mahsa Kheirollahi Chadegani, Caroline Dalgliesh, Simon Cockell, Graham Smith, Gerald Hysenaj, David J. Elliott, Ingrid Ehrmann, Yoseph Barash, Katherine James
Previously we showed that the germline-specific RNA binding protein RBMXL2 is essential for male meiosis where it represses cryptic splicing patterns (1). Here we find that its ubiquitously expressed paralog RBMX helps underpin human genome stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a9b0181c6215da154a9e837c52025e9
https://doi.org/10.1101/2020.10.09.333039
https://doi.org/10.1101/2020.10.09.333039
