Synthesis of epibatidine isomers: endo-5- and 6- (6′-chloro-3′-pyridyl-2-azabicyclo[2.2.1]heptanes

Autor: John C. Gordon, Caroline D. Cox, Alan Rosen, John R. Malpass

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :2372-2379

Synthesis of the title compounds is described; detailed NMR data are provided in support of the proposed stereostructures. The 5- and 6-endo-compounds show high selectivity for α4β2 versus α7 nAChR subtypes; in contrast, the exo-stereoisomers show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc4537d2ad51902261a97ce8fd95874d
https://doi.org/10.1039/b106212n

Synthesis of 5- and 6- chloropyridyl-substituted 2-azabicyclo[2.2.1]heptanes; novel epibatidine isomers

Autor: John R. Malpass, Caroline D. Cox

Publikováno v: Tetrahedron Letters. 40:1419-1422

A synthetic route to the epibatidine analogue endo-5-(6-chloro-3-pyridyl)-2-azabicyclo[2.2.1]heptane and the corresponding endo-6- isomer is described, starting from a readily-available 2-azabicyclo[2.2.1]hept-5-ene derivative. Both the exo-5- and ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::607df5e824c6234a8704a86f540b82e2
https://doi.org/10.1016/s0040-4039(98)02624-0

ChemInform Abstract: Synthesis of 5- and 6-Chloropyridyl-Substituted 2-Azabicyclo[2.2.1]heptanes; Novel Epibatidine Isomers

Autor: Caroline D. Cox, John R. Malpass

Publikováno v: ChemInform. 30

A synthetic route to the epibatidine analogue endo-5-(6-chloro-3-pyridyl)-2-azabicyclo[2.2.1]heptane and the corresponding endo-6- isomer is described, starting from a readily-available 2-azabicyclo[2.2.1]hept-5-ene derivative. Both the exo-5- and ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6957a650db25e203cdf4448719a1b7f3
https://doi.org/10.1002/chin.199919242

The finished DNA sequence of human chromosome 12

Autor: Steven E, Scherer, Donna M, Muzny, Christian J, Buhay, Rui, Chen, Andrew, Cree, Yan, Ding, Shannon, Dugan-Rocha, Rachel, Gill, Preethi, Gunaratne, R Alan, Harris, Alicia C, Hawes, Judith, Hernandez, Anne V, Hodgson, Jennifer, Hume, Andrew, Jackson, Ziad Mohid, Khan, Christie, Kovar-Smith, Lora R, Lewis, Ryan J, Lozado, Michael L, Metzker, Aleksandar, Milosavljevic, George R, Miner, Kate T, Montgomery, Margaret B, Morgan, Lynne V, Nazareth, Graham, Scott, Erica, Sodergren, Xing-Zhi, Song, David, Steffen, Ruth C, Lovering, David A, Wheeler, Kim C, Worley, Yi, Yuan, Zhengdong, Zhang, Charles Q, Adams, M Ali, Ansari-Lari, Mulu, Ayele, Mary J, Brown, Guan, Chen, Zhijian, Chen, Kerstin P, Clerc-Blankenburg, Clay, Davis, Oliver, Delgado, Huyen H, Dinh, Heather, Draper, Manuel L, Gonzalez-Garay, Paul, Havlak, Laronda R, Jackson, Leni S, Jacob, Susan H, Kelly, Li, Li, Zhangwan, Li, Jing, Liu, Wen, Liu, Jing, Lu, Manjula, Maheshwari, Bao-Viet, Nguyen, Geoffrey O, Okwuonu, Shiran, Pasternak, Lesette M, Perez, Farah J H, Plopper, Jireh, Santibanez, Hua, Shen, Paul E, Tabor, Daniel, Verduzco, Lenee, Waldron, Qiaoyan, Wang, Gabrielle A, Williams, Jingkun, Zhang, Jianling, Zhou, Carlana C, Allen, Anita G, Amin, Vivian, Anyalebechi, Michael, Bailey, Joseph A, Barbaria, Kesha E, Bimage, Nathaniel P, Bryant, Paula E, Burch, Carrie E, Burkett, Kevin L, Burrell, Eliana, Calderon, Veronica, Cardenas, Kelvin, Carter, Kristal, Casias, Iracema, Cavazos, Sandra R, Cavazos, Heather, Ceasar, Joseph, Chacko, Sheryl N, Chan, Dean, Chavez, Constantine, Christopoulos, Joseph, Chu, Raynard, Cockrell, Caroline D, Cox, Michelle, Dang, Stephanie R, Dathorne, Robert, David, Candi Mon'Et, Davis, Latarsha, Davy-Carroll, Denise R, Deshazo, Jeremy E, Donlin, Lisa, D'Souza, Kristy A, Eaves, Amy, Egan, Alexandra J, Emery-Cohen, Michael, Escotto, Nicole, Flagg, Lisa D, Forbes, Abdul M, Gabisi, Melissa, Garza, Cerissa, Hamilton, Nicholas, Henderson, Omar, Hernandez, Sandra, Hines, Marilyn E, Hogues, Mei, Huang, DeVincent G, Idlebird, Rudy, Johnson, Angela, Jolivet, Sally, Jones, Ryan, Kagan, Laquisha M, King, Belita, Leal, Heather, Lebow, Sandra, Lee, Jaclyn M, LeVan, Lakeshia C, Lewis, Pamela, London, Lorna M, Lorensuhewa, Hermela, Loulseged, Demetria A, Lovett, Alice, Lucier, Raymond L, Lucier, Jie, Ma, Renita C, Madu, Patricia, Mapua, Ashley D, Martindale, Evangelina, Martinez, Elizabeth, Massey, Samantha, Mawhiney, Michael G, Meador, Sylvia, Mendez, Christian, Mercado, Iracema C, Mercado, Christina E, Merritt, Zachary L, Miner, Emmanuel, Minja, Teresa, Mitchell, Farida, Mohabbat, Khatera, Mohabbat, Baize, Montgomery, Niki, Moore, Sidney, Morris, Mala, Munidasa, Robin N, Ngo, Ngoc B, Nguyen, Elizabeth, Nickerson, Ogechi O, Nwaokelemeh, Stanley, Nwokenkwo, Melissa, Obregon, Maryann, Oguh, Njideka, Oragunye, Rodolfo J, Oviedo, Bridgette J, Parish, David N, Parker, Julia, Parrish, Kenya L, Parks, Heidie A, Paul, Brett A, Payton, Agapito, Perez, William, Perrin, Adam, Pickens, Eltrick L, Primus, Ling-Ling, Pu, Maria, Puazo, Miyo M, Quiles, Juana B, Quiroz, Dina, Rabata, Kacy, Reeves, San Juana, Ruiz, Hongmei, Shao, Ida, Sisson, Titilola, Sonaike, Richard P, Sorelle, Angelica E, Sutton, Amanda F, Svatek, Leah Anne, Svetz, Kavitha S, Tamerisa, Tineace R, Taylor, Brian, Teague, Nicole, Thomas, Rachel D, Thorn, Zulma Y, Trejos, Brenda K, Trevino, Ogechi N, Ukegbu, Jeremy B, Urban, Lydia I, Vasquez, Virginia A, Vera, Donna M, Villasana, Ling, Wang, Stephanie, Ward-Moore, James T, Warren, Xuehong, Wei, Flower, White, Angela L, Williamson, Regina, Wleczyk, Hailey S, Wooden, Steven H, Wooden, Jennifer, Yen, Lillienne, Yoon, Vivienne, Yoon, Sara E, Zorrilla, David, Nelson, Raju, Kucherlapati, George, Weinstock, Richard A, Gibbs

Publikováno v: Nature. 440(7082)

Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b388f525fc0ae54d0bb314d806450da4
https://pubmed.ncbi.nlm.nih.gov/16541075