Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Caroline Contat"'
1
Akademický článek
Durable and controlled depletion of neutrophils in mice
Autor: Gael Boivin, Julien Faget, Pierre-Benoit Ancey, Aspasia Gkasti, Julie Mussard, Camilla Engblom, Christina Pfirschke, Caroline Contat, Justine Pascual, Jessica Vazquez, Nathalie Bendriss-Vermare, Christophe Caux, Marie-Catherine Vozenin, Mikael J. Pittet, Matthias Gunzer, Etienne Meylan
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Anti-Ly6G or ant-Gr1 antibodies are commonly used to deplete neutrophils in vivo. Here the authors provide mechanistic insight into why these approaches may not specifically or durably reduce the number of neutrophils in mice, and also present a new
Externí odkaz: https://doaj.org/article/d3653b7e42a14239a9541459d01f0ce4
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2
Akademický článek
Anti-Ly6G binding and trafficking mediate positive neutrophil selection to unleash the anti-tumor efficacy of radiation therapy
Autor: Gaël Boivin, Pierre-Benoit Ancey, Romain Vuillefroy de Silly, Pradeep Kalambaden, Caroline Contat, Benoit Petit, Jonathan Ollivier, Jean Bourhis, Etienne Meylan, Marie-Catherine Vozenin
Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
The anti-Ly6G antibody is used to deplete Ly6Gpos neutrophils and study their role in diverse pathologies. However, depletion is never absolute, as Ly6Glow neutrophils resistant to depletion rapidly emerge. Studying the functionality of these residua
Externí odkaz: https://doaj.org/article/d859437683ad47369e5adee3a49c5195
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3
Akademický článek
Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth
Autor: Caroline Contat, Pierre-Benoit Ancey, Nadine Zangger, Silvia Sabatino, Justine Pascual, Stéphane Escrig, Louise Jensen, Christine Goepfert, Bernard Lanz, Mario Lepore, Rolf Gruetter, Anouk Rossier, Sabina Berezowska, Christina Neppl, Inti Zlobec, Stéphanie Clerc-Rosset, Graham William Knott, Jeffrey C Rathmell, E Dale Abel, Anders Meibom, Etienne Meylan
Publikováno v: eLife, Vol 9 (2020)
Glucose utilization increases in tumors, a metabolic process that is observed clinically by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are
Externí odkaz: https://doaj.org/article/c3aba89d5d7741e7b31b5d7c0de19941
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7
Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy
Autor: Marie-Catherine Vozenin, Nadine Zangger, Caroline Contat, Jean Yannis Perentes, Justine Pascual, Gael Boivin, Silvia Sabatino, David G. Kirsch, Jeffrey C. Rathmell, Solange Peters, E. Dale Abel, Etienne Meylan, Pierre-Benoit Ancey
Publikováno v: Cancer Res
Neutrophils are the most abundant circulating leucocytes and are essential for innate immunity. In cancer, pro- or antitumor properties have been attributed to tumor-associated neutrophils (TAN). Here, focusing on TAN accumulation within lung tumors,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a70135a01edf5a4dad5e526507bf89
https://europepmc.org/articles/PMC8137580/
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9
Glucose transporters in cancer – from tumor cells to the tumor microenvironment
Autor: Etienne Meylan, Caroline Contat, Pierre-Benoit Ancey
Publikováno v: The FEBS Journal. 285:2926-2943
Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular glucose usage. The upregulation of GLUTs has been reported in numerous cancer types as a result of perturbation of gene expression or protein relocalization
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e832e8ff12560116bab6a0f22a3e0c5
https://doi.org/10.1111/febs.14577
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10
RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma
Autor: Caroline Contat, Julien Faget, Nadine Zangger, Solange Peters, Etienne Meylan
Publikováno v: Journal of Thoracic Oncology
Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2018, 13 (3), pp.387-398. ⟨10.1016/j.jtho.2017.11.121⟩
Journal of thoracic oncology, vol. 13, no. 3, pp. 387-398
SummaryHypothesisNon-small cell lung cancer (NSCLC) is the leading cause of cancer mortality. Recent retrospective clinical analyses suggest that blocking the receptor activator of NF-κB (RANK) signaling pathway inhibits the growth of NSCLC and migh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49921f2890affd134b1bc7f6fcaa6ce3
https://pubmed.ncbi.nlm.nih.gov/29223537
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