Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Caroline Colley"'
Autor:
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozora
Externí odkaz:
https://doaj.org/article/4d1e1f2da3f148aa85e1df6a32f0ef69
Autor:
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozorakimab (ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2623b7a64721c16cead1782c6553f513
https://doi.org/10.1101/2023.02.28.527262
https://doi.org/10.1101/2023.02.28.527262
Autor:
David Hargeaves, Elizabeth England, Robert M. Woods, Michael Fung, Caroline Colley, Paul Warrener, Liz Flavell, Sudharsan Sridharan, Judit E. Debreczeni, Jessica Bonnell, Claire Dobson, Jingying Zha, Bryan M. Edwards, Ling-Ling An, Laura Eghobamien, Ulf Sivars, Joanne Arnold, Jonathan Renshaw, Bojana Popovic, Kate F. Wickson, Tristan J. Vaughan, Trevor Wilkinson
Publikováno v:
mAbs
'mAbs ', vol: 10, pages: 104-117 (2018)
'mAbs ', vol: 10, pages: 104-117 (2018)
C5a is a potent anaphylatoxin that modulates inflammation through the C5aR1 and C5aR2 receptors. The molecular interactions between C5a–C5aR1 receptor are well defined, whereas C5a–C5aR2 receptor interactions are poorly understood. Here, we descr
Publikováno v:
Current protocols in pharmacology. 82(1)
Ion channels play crucial roles in physiology by modulation of cellular functions that include electrical excitability, secretion, cell migration, and gene transcription. They are an important target class for drug discovery and have historically bee
Autor:
Caroline Colley, Christine J. Rossant, Trevor Wilkinson, David Lowne, Joanne Arnold, Sadhana Podichetty, Claire Dobson, Frances Neal, Rob Howes, Tristan J. Vaughan
Publikováno v:
Journal of biomolecular screening. 21(1)
Calcitonin gene-related peptide (CGRP) is a small neuropeptide and a potent vasodilator that is widely associated with chronic pain and migraine. An antibody that inhibits CGRP function would be a potential therapeutic for treatment of these disorder
Autor:
Caroline Colley, Tristan J. Vaughan, Christine J. Rossant, Carl Anthony Matthews, Frances Neal, Matthew J. Gardener
Publikováno v:
Journal of biomolecular screening. 20(4)
Identification of potential lead antibodies in the drug discovery process requires the use of assays that not only measure binding of the antibody to the target molecule but assess a wide range of other characteristics. These include affinity ranking
Autor:
Christine J. Rossant, Caroline Colley, Elizabeth England, Frances Neal, Lisa Kitching, Philip Newton
Publikováno v:
Journal of biomolecular screening. 20(4)
Highly sensitive, high-throughput assay technologies are required for the identification of antibody therapeutics. Multiplexed assay systems are particularly advantageous because they allow evaluation of several parameters within 1 well, increasing t
Autor:
Bret R. Sellman, Joanne Brennan, Kaiyong Yang, Jingying Zha, Roland Kolbeck, Claire Dobson, Ling-Ling An, Michael Fung, Caroline Colley, Paul Warrener
Publikováno v:
Immunobiology. 217:1219