Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

Autor: Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozora

Externí odkaz: https://doaj.org/article/4d1e1f2da3f148aa85e1df6a32f0ef69

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors

Autor: David Hargeaves, Elizabeth England, Robert M. Woods, Michael Fung, Caroline Colley, Paul Warrener, Liz Flavell, Sudharsan Sridharan, Judit E. Debreczeni, Jessica Bonnell, Claire Dobson, Jingying Zha, Bryan M. Edwards, Ling-Ling An, Laura Eghobamien, Ulf Sivars, Joanne Arnold, Jonathan Renshaw, Bojana Popovic, Kate F. Wickson, Tristan J. Vaughan, Trevor Wilkinson

Publikováno v: mAbs
'mAbs ', vol: 10, pages: 104-117 (2018)

C5a is a potent anaphylatoxin that modulates inflammation through the C5aR1 and C5aR2 receptors. The molecular interactions between C5a–C5aR1 receptor are well defined, whereas C5a–C5aR2 receptor interactions are poorly understood. Here, we descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3b26c96696e2eb620d74383a366038
http://europepmc.org/articles/PMC5800367

Isolation of Potent CGRP Neutralizing Antibodies Using Four Simple Assays

Autor: Caroline Colley, Christine J. Rossant, Trevor Wilkinson, David Lowne, Joanne Arnold, Sadhana Podichetty, Claire Dobson, Frances Neal, Rob Howes, Tristan J. Vaughan

Publikováno v: Journal of biomolecular screening. 21(1)

Calcitonin gene-related peptide (CGRP) is a small neuropeptide and a potent vasodilator that is widely associated with chronic pain and migraine. An antibody that inhibits CGRP function would be a potential therapeutic for treatment of these disorder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6db2d3b87dfc70da13474714bc20559
https://pubmed.ncbi.nlm.nih.gov/26450103

Application of the mirrorball high-sensitivity cytometer to multiplexed assays for antibody drug discovery

Autor: Christine J. Rossant, Caroline Colley, Elizabeth England, Frances Neal, Lisa Kitching, Philip Newton

Publikováno v: Journal of biomolecular screening. 20(4)

Highly sensitive, high-throughput assay technologies are required for the identification of antibody therapeutics. Multiplexed assay systems are particularly advantageous because they allow evaluation of several parameters within 1 well, increasing t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93086580b0fcd69d729d1d0c6a41f641
https://pubmed.ncbi.nlm.nih.gov/25381256

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.

Autor: England, Elizabeth¹ (AUTHOR), Rees, D. Gareth¹ (AUTHOR), Scott, Ian Christopher² (AUTHOR), Carmen, Sara¹ (AUTHOR), Chan, Denice T. Y.¹ (AUTHOR), Chaillan Huntington, Catherine E.¹ (AUTHOR), Houslay, Kirsty F.³ (AUTHOR), Erngren, Teodor⁴ (AUTHOR), Penney, Mark⁵ (AUTHOR), Majithiya, Jayesh B.³ (AUTHOR), Rapley, Laura³ (AUTHOR), Sims, Dorothy A.⁶ (AUTHOR), Hollins, Claire³ (AUTHOR), Hinchy, Elizabeth C.³ (AUTHOR), Strain, Martin D.¹ (AUTHOR), Kemp, Benjamin P.¹ (AUTHOR), Corkill, Dominic J.⁷ (AUTHOR), May, Richard D.³ (AUTHOR), Vousden, Katherine A.¹ (AUTHOR), Butler, Robin J.¹ (AUTHOR)

Publikováno v: Scientific Reports. 6/17/2023, Vol. 13 Issue 1, p1-15. 15p.