Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Caroline Cilissen"'
Autor:
Steven V. Fox, Kate Mostoller, Steve Warrington, Chris Min, Caroline Cilissen, Marion Wittmann, Douglas C. Beshore, Dawn Harris, Henry S. Lange, Natasa Pajkovic, Jason M. Uslaner, Chantal Mahon, Scott D. Kuduk
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:556-566
The current standard of care for treating Alzheimer's disease is acetylcholinesterase inhibitors, which nonselectively increase cholinergic signaling by indirectly enhancing activity of nicotinic and muscarinic receptors. These drugs improve cognitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21df26582717ec1aa725263055cd8e11
https://doi.org/10.1124/jpet.117.245894
https://doi.org/10.1124/jpet.117.245894
Autor:
Zifang Guo, Marleen Depré, Naoto Uemura, Anderson, DH Wright, Joan R. Butterton, Caroline Cilissen, W. Gao, Luzelena Caro, SL Troemel, J Miller, Deborah Panebianco, John A. Wagner, J de Hoon
Publikováno v:
Clinical and Translational Science
Vaniprevir is an inhibitor of the hepatitis C virus (HCV) NS3/4A protease. The aim of these double-blind, placebo-controlled phase I studies was to evaluate the safety and pharmacokinetics of vaniprevir in healthy male volunteers. The primary objecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1baf72fdbefb6f3872ca67051311e44d
http://europepmc.org/articles/PMC6402189
http://europepmc.org/articles/PMC6402189
Autor:
Caroline Cilissen, Christopher Chung, Sudha S. Shankar, David E. Kelley, Deborah L. Miller, Chan R. Beals, S. Aubrey Stoch, R. Ravi Shankar, Lori A. Mixson, Helmut O. Steinberg
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 310:E865-E873
The graded glucose infusion (GGI) examines insulin secretory response patterns to continuously escalating glycemia. The current study series sought to more fully appraise its performance characteristics. Key questions addressed were comparison of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edf527badba62febe9641ab0e60ad0e
https://doi.org/10.1152/ajpendo.00527.2015
https://doi.org/10.1152/ajpendo.00527.2015
Autor:
Jason M, Uslaner, Scott D, Kuduk, Marion, Wittmann, Henry S, Lange, Steve V, Fox, Chris, Min, Natasa, Pajkovic, Dawn, Harris, Caroline, Cilissen, Chantal, Mahon, Kate, Mostoller, Steve, Warrington, Douglas C, Beshore
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 365(3)
The current standard of care for treating Alzheimer's disease is acetylcholinesterase inhibitors, which nonselectively increase cholinergic signaling by indirectly enhancing activity of nicotinic and muscarinic receptors. These drugs improve cognitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1289b39b58405a6af4a2971608932265
https://pubmed.ncbi.nlm.nih.gov/29563325
https://pubmed.ncbi.nlm.nih.gov/29563325
Autor:
D. Hamish Wright, Keith Gottesdiener, Ronald B. Langdon, Eseng Lai, Larissa Wenning, Julie A. Stone, Caroline Cilissen, Li Sun, Wei Zheng, Steven Ramael, Amy Y. Yang, Kerri Yan, Tami Crumley, Anne Hermanowski-Vosatka, John A. Wagner
Publikováno v:
British Journal of Clinical Pharmacology. 76:917-931
Aims To characterize pharmacokinetic parameters of MK-0916 and its safety and tolerability in lean, healthy male subjects following single and multiple oral doses. To assess (by stable-isotope labelling) the in vivo inhibition of cortisone-to-cortiso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5550c57b10689ada6344f5c1e82cfb9d
https://doi.org/10.1111/bcp.12131
https://doi.org/10.1111/bcp.12131
Autor:
Julie A. Stone, John A. Wagner, Lucas Van Bortel, S. Aubrey Stoch, Deborah Panebianco, Barnali Pramanik, Caroline Cilissen, Stefan Zajic, Deborah L. Miller, Keith Gottesdiener, Lida Liu, Q Liu, Kenneth C. Lasseter, Yu Ding, Boyd B. Scott
Publikováno v:
British Journal of Clinical Pharmacology. 75:1240-1254
Aims: To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of odanacatib (ODN), a cathepsin K inhibitor, in humans. Methods: Two double-blind, randomized, placebo-controlled, single oral dose studies were performed with ODN (26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c332760a0f16d5ddf5878e766766d1b6
https://doi.org/10.1111/j.1365-2125.2012.04471.x
https://doi.org/10.1111/j.1365-2125.2012.04471.x
Autor:
Mark Kipnes, Amy Qiu Wang, Deborah Hilliard, Kenneth C. Lasseter, John A. Wagner, Karen Snyder, Keith Gottesdiener, Wesley Tanaka, Bruno Dietrich, Jens J. Holst, Peng Zhao, Andreas Schrodter, Bart Keymeulen, Catherine Stevens, Carolyn F. Deacon, Kristien Van Dyck, Inge De Lepeleire, Caroline Cilissen, Arthur J. Bergman, Gary A. Herman, Wei Zeng, Marina De Smet, George Golor, Bingming Yi, Michael J. Davies, Paul Kotey, Michael Tanen
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:4612-4619
In response to a meal, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are released and modulate glycemic control. Normally these incretins are rapidly degraded by dipeptidyl peptidase-4 (DPP-4). DPP-4 inhibitors ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a6916322ba857ce28d9407665e271c
https://doi.org/10.1210/jc.2006-1009
https://doi.org/10.1210/jc.2006-1009
Autor:
Inge De Lepeleire, Luc M. Van Bortel, Rachael Liu, Matt S. Anderson, June K Ancona, Marissa F. Dockendorf, Ying Guo, Ernestina Tetteh, John A. Wagner, Joan R. Butterton, Jocelyn Gilmartin, Caroline Cilissen
Publikováno v:
Antiviral therapy. 20(4)
Background Doravirine is a novel non-nucleoside inhibitor of HIV-1 reverse transcriptase with potent activity against wild-type virus (95% inhibitory concentration 19 nM, 50% human serum). Doravirine has low potential to cause drug–drug interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b456f1bcbeb2fd071da43c9da50e00
https://pubmed.ncbi.nlm.nih.gov/25470746
https://pubmed.ncbi.nlm.nih.gov/25470746
Autor:
Stephanie Curry, L. Maganti, Ernest Asante-Appiah, William L. Marshall, Daria J. Hazuda, Serghei Popa, Edward Gane, Caroline Cilissen, W. Gao, G. Garrett, T. Black, Patricia McMonagle, Joan R. Butterton, I. De Lepeleire
Publikováno v:
Journal of Hepatology. 64:S402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1be5742386001094597f233075042a
https://doi.org/10.1016/s0168-8278(16)00635-8
https://doi.org/10.1016/s0168-8278(16)00635-8
Autor:
S Aubrey, Stoch, Stefan, Zajic, Julie A, Stone, Deborah L, Miller, Lucas, van Bortel, Kenneth C, Lasseter, Barnali, Pramanik, Caroline, Cilissen, Qi, Liu, Lida, Liu, Boyd B, Scott, Deborah, Panebianco, Yu, Ding, Keith, Gottesdiener, John A, Wagner
Publikováno v:
British journal of clinical pharmacology. 75(5)
To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of odanacatib (ODN), a cathepsin K inhibitor, in humans.Two double-blind, randomized, placebo-controlled, single oral dose studies were performed with ODN (2-600 mg) in 44 he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::222384591218497aa9d4862d2004b7e6
https://pubmed.ncbi.nlm.nih.gov/23013236
https://pubmed.ncbi.nlm.nih.gov/23013236