Mitigating jaw osteonecrosis: bioactive glass and pericardial membrane combination in a rat model

Autor: Alexandre Antonio Pellicano, Bernar M. Benites, Amanda F. N. Paschoa, Laura C. Oliveira, Ana Carolina P. Campos, Daniel O. Martins, Caroline C. Real, Daniele de Paula Faria, Felipe P. Fonseca, Raquel R. C. Martinez, Rosana L. Pagano, Eduardo R. Fregnani

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

ObjectivesBisphosphonates (BFs) show clinical effectiveness in managing osteoporosis and bone metastases but pose risks of bisphosphonate-related jaw osteonecrosis (BRONJ). With no established gold standard for BRONJ treatment, our focus is on sympto

Externí odkaz: https://doaj.org/article/f6039458603c498ebbceaaeaaa3dbadb

A single dose of cocaine raises SV2A density in hippocampus of adolescent rats

Autor: Rachele Rossi, Simone Larsen Bærentzen, Majken B. Thomsen, Caroline C. Real, Gregers Wegener, Rodrigo Grassi-Oliveira, Albert Gjedde, Anne M. Landau

Publikováno v: Rossi, R, Bærentzen, S L, Thomsen, M, Real, C C, Wegener, G, Grassi-Oliveira, R, Gjedde, A & Landau, A 2023, ' A single dose of cocaine raises SV2A density in hippocampus of adolescent rats ', Acta Neuropsychiatrica .

Objective Cocaine is a highly addictive psychostimulant that affects synaptic activity with structural and functional adaptations of neurons. The transmembrane synaptic vesicle glycoprotein 2A (SV2A) of pre-synaptic vesicles is commonly used to measu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f70a80577828cf19d57c87e719faf8f
https://doi.org/10.1017/neu.2023.14

Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs

Autor: Thea P. Lillethorup, Ove Noer, Aage Kristian Olsen Alstrup, Caroline C. Real, Kathrine Stokholm, Majken Borup Thomsen, Hamed Zaer, Dariusz Orlowski, Trine Werenberg Mikkelsen, Andreas N. Glud, Erik Holm Toustrup Nielsen, Anna C. Schacht, Michael Winterdahl, David J. Brooks, Jens Christian H. Sørensen, Anne M. Landau

Publikováno v: Lillethorup, T P, Noer, O, Alstrup, A K O, Real, C C, Stokholm, K, Thomsen, M B, Zaer, H, Orlowski, D, Mikkelsen, T W, Glud, A N, Nielsen, E H T, Schacht, A C, Winterdahl, M, Brooks, D J, Sørensen, J C H & Landau, A M 2022, ' Spontaneous Partial Recovery of Striatal Dopaminergic Uptake Despite Nigral Cell Loss in Asymptomatic MPTP-Lesioned Female Minipigs ', NeuroToxicology . https://doi.org/10.1016/j.neuro.2022.05.006
Lillethorup, T P, Noer, O, Alstrup, A K O, Cristiano Real Gregório, C, Stokholm, K, Thomsen, M, Zaer, H, Orlowski, D, Mikkelsen, T W, Glud, AN, Nielsen, E H T, Schacht, A C, Winterdahl, M, Brooks, D J, Sørensen, J C H & Landau, A 2022, ' Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs ', NeuroToxicology, vol. 91, pp. 166-176 . https://doi.org/10.1016/j.neuro.2022.05.006

The Göttingen minipig is a large animal with a gyrencephalic brain that expresses complex behaviour, making it an attractive model for Parkinson's disease research. Here, we investigate the temporal evolution of presynaptic dopaminergic function for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32413bc32e32832cc10a8107f5514a0f
https://pubmed.ncbi.nlm.nih.gov/35569565

Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases Abordagens diferentes, um único objetivo: compreender os mecanismos celulares das doenças de Parkinson e de Alzheimer

Autor: Andréa S. Torrão, Cecilia C. Café-Mendes, Caroline C. Real, Marina S. Hernandes, Ana F. B. Ferreira, Taisa O. Santos, Gabriela P. Chaves-Kirsten, Caio H. Y. Mazucanti, Emer S. Ferro, Cristoforo Scavone, Luiz R. G. Britto

Publikováno v: Brazilian Journal of Psychiatry, Vol 34, Pp s194-s205 (2012)

Neurodegenerative disorders are undoubtedly an increasing problem in the health sciences, given the increase of life expectancy and occasional vicious life style. Despite the fact that the mechanisms of such diseases are far from being completely und

Externí odkaz: https://doaj.org/article/80f47e5f2a114a97a86caec099693891

Heterobivalent Dual-Target Peptide for Integrin-α v β 3 and Neuropeptide Y Receptors on Breast Tumor.

Autor: Ferreira, Aryel H.^1,2,3 (AUTHOR) aryel.ferreira@mackenzie.br, Real, Caroline C.⁴ (AUTHOR), Malafaia, Osvaldo² (AUTHOR)

Publikováno v: Pharmaceuticals (14248247). Oct2024, Vol. 17 Issue 10, p1328. 13p.