Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Caroline C. McGown"'
Publikováno v:
Expert Review of Neurotherapeutics. 10:1505-1517
Almotriptan, a serotonin 5-HT 1B/1D agonist, was developed for the acute treatment of migraine with or without aura and has been available for 10 years. This article evaluates the wealth of experience that has been obtained with almotriptan, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed6a73cfa06628216cdceb9ed8d2db4
https://doi.org/10.1586/ern.10.131
https://doi.org/10.1586/ern.10.131
Autor:
Arnaud Mansart, Caroline C. McGown, Charles S. Reilly, Nicola J. Brown, Zoë L. S. Brookes, Jonathan J. Ross
Publikováno v:
Lymphatic Research and Biology. 7:131-137
The spleen has an important physiological role in maintaining blood volume; this study aimed to determine whether during pathophysiological circumstances, namely endotoxemia, the extrasplenic pathway is dysfunctional. We hypothesize that increased 'l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31129bbb0709b15ff3285b9b861b6c51
https://doi.org/10.1089/lrb.2008.1019
https://doi.org/10.1089/lrb.2008.1019
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 388(5)
In a lipopolysaccharide (LPS)-induced rat model of sepsis (endotoxaemia), we previously demonstrated that pravastatin reduced microvascular inflammation via increased endothelial nitric oxide synthase III (NOSIII). This study aimed to determine wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ab8f1ab582150e324151eea96802af
https://pubmed.ncbi.nlm.nih.gov/25678054
https://pubmed.ncbi.nlm.nih.gov/25678054
Publikováno v:
Current medical research and opinion. 27(3)
The START study was a large general practice observational study involving 400 patients with migraine. Given the large sample size, a sub-analysis was planned to ascertain whether any patient characteristics/behaviors might help predict/explain the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1007fdbaf0c4ccd613ebc3f14b8c118f
https://pubmed.ncbi.nlm.nih.gov/21222569
https://pubmed.ncbi.nlm.nih.gov/21222569
Autor:
Erno Vreugdenhil, Caroline C. McGown, Barbera Veldhuisen, Olga Wedemeier, Theo G. Schouten, Melly S. Oitzl, Geert J. Schenk, E. Ron de Kloet
Publikováno v:
Physiology and Behavior, 101(4), 541-548
Products of the Doublecortin-Like Kinase (DCLK) gene are associated with cortical migration and hippocampal maturation during embryogenesis However the functions of those DCLK gene transcripts that encode kinases and are expressed during adulthood ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db55ec39ff6aaf8593cce1214972099b
http://hdl.handle.net/1887/110442
http://hdl.handle.net/1887/110442
Publikováno v:
Expert review of neurotherapeutics. 10(9)
In a large observational general practice study (the Standardized Study with Almotriptan in Early Treatment of Migraine [START]), 12.5 mg almotriptan administered within 1 h of pain onset and when pain was mild significantly improved pain-related out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30379d98e6c83c0aaa418dc0f6962bee
https://pubmed.ncbi.nlm.nih.gov/20819011
https://pubmed.ncbi.nlm.nih.gov/20819011
Publikováno v:
Microvascular research. 81(3)
Sepsis may be modeled using lipopolysaccharide (LPS), which alters levels of nitric oxide (NO), synthesized via endothelial and inducible nitric oxide synthase (eNOS and iNOS). This study aimed to determine whether the Rho kinase (ROCK) inhibitor fas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c86b4a33dcd2dfc75c6a9a737b8202e
https://pubmed.ncbi.nlm.nih.gov/21354186
https://pubmed.ncbi.nlm.nih.gov/21354186
Publikováno v:
British journal of anaesthesia. 104(2)
Sepsis induces microvascular inflammation and production of the vasodilator nitric oxide (NO) via endothelial and inducible nitric oxide synthase (eNOS or NOS III and iNOS or NOS II). Statins are cholesterol-lowering drugs; however, they also attenua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0a04a4c944e9023b33929c48800de6
https://pubmed.ncbi.nlm.nih.gov/20086063
https://pubmed.ncbi.nlm.nih.gov/20086063
Publikováno v:
British journal of anaesthesia. 103(1)
The use of statins is widespread and many patients presenting for surgery are regularly taking them. There is evidence that statins have beneficial effects beyond those of lipid lowering, including reducing the perioperative risk of cardiac complicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a58ac24ab5f15fdc0697170182b743a
https://pubmed.ncbi.nlm.nih.gov/19502286
https://pubmed.ncbi.nlm.nih.gov/19502286
Autor:
Caroline C. McGown, Zoë L. S. Brookes
Publikováno v:
British journal of anaesthesia. 98(2)
This review describes the laboratory evidence and microvascular mechanisms responsible for the beneficial effects of statins in sepsis. During sepsis, changes occur within the microcirculation including alterations in arteriolar tone influencing bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a58a7b48a4b2c5664e0c5582155ed5d
https://pubmed.ncbi.nlm.nih.gov/17251210
https://pubmed.ncbi.nlm.nih.gov/17251210